Imperial College London

ProfessorPaulElliott

Faculty of MedicineSchool of Public Health

Chair in Epidemiology and Public Health Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3328p.elliott Website

 
 
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Assistant

 

Miss Jennifer Wells +44 (0)20 7594 3328

 
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Location

 

154Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Huang:2020:10.1016/j.ahj.2019.12.020,
author = {Huang, L and Tian, M and Yu, J and Li, Q and Liu, Y and Yin, X and Wu, JH and Marklund, M and Wu, Y and Li, N and Elliott, P and Yan, LL and Labarthe, DR and Hao, Z and Shi, J and Feng, X and Zhang, J and Zhang, Y and Zhang, R and Zhou, B and Li, Z and Sun, J and Zhao, Y and Yu, Y and Neal, B},
doi = {10.1016/j.ahj.2019.12.020},
journal = {American Heart Journal},
pages = {136--145},
title = {Interim effects of salt substitution on urinary electrolytes and blood pressure in the China Salt Substitute and Stroke Study (SSaSS)},
url = {http://dx.doi.org/10.1016/j.ahj.2019.12.020},
volume = {221},
year = {2020}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The Salt Substitute and Stroke Study is an ongoing 5-year large-scale cluster randomized trial investigating the effects of potassium-enriched salt substitute compared to usual salt on the risk of stroke. The study involves 600 villages and 20,996 individuals in rural China. Intermediate risk markers were measured in a random subsample of villages every 12 months over 3 years to track progress against key assumptions underlying study design. Measures of 24-hour urinary sodium, 24-hour urinary potassium, blood pressure and participants' use of salt substitute were recorded, with differences between intervention and control groups estimated using generalized linear mixed models. The primary outcome of annual event rate in the two groups combined was determined by dividing confirmed fatal and non-fatal strokes by total follow-up time in the first 2 years. The mean differences (95% CI) were -0.32 g (-0.68 to 0.05) for 24-hour urinary sodium, +0.77 g (+0.60 to +0.93) for 24-hour urinary potassium, -2.65 mmHg (-4.32 to -0.97) for systolic blood pressure and +0.30 mmHg (-0.72 to +1.32) for diastolic blood pressure. Use of salt substitute was reported by 97.5% in the intervention group versus 4.2% in the control group (P<.0001). The overall estimated annual event rate for fatal and non-fatal stroke was 3.2%. The systolic blood pressure difference and the annual stroke rate were both in line with the statistical assumptions underlying study design. The trial should be well placed to address the primary hypothesis at completion of follow-up.
AU - Huang,L
AU - Tian,M
AU - Yu,J
AU - Li,Q
AU - Liu,Y
AU - Yin,X
AU - Wu,JH
AU - Marklund,M
AU - Wu,Y
AU - Li,N
AU - Elliott,P
AU - Yan,LL
AU - Labarthe,DR
AU - Hao,Z
AU - Shi,J
AU - Feng,X
AU - Zhang,J
AU - Zhang,Y
AU - Zhang,R
AU - Zhou,B
AU - Li,Z
AU - Sun,J
AU - Zhao,Y
AU - Yu,Y
AU - Neal,B
DO - 10.1016/j.ahj.2019.12.020
EP - 145
PY - 2020///
SN - 0002-8703
SP - 136
TI - Interim effects of salt substitution on urinary electrolytes and blood pressure in the China Salt Substitute and Stroke Study (SSaSS)
T2 - American Heart Journal
UR - http://dx.doi.org/10.1016/j.ahj.2019.12.020
UR - https://www.ncbi.nlm.nih.gov/pubmed/31986290
UR - http://hdl.handle.net/10044/1/76757
VL - 221
ER -