Imperial College London

ProfessorPaulElliott

Faculty of MedicineSchool of Public Health

Chair in Epidemiology and Public Health Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3328p.elliott Website

 
 
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Assistant

 

Miss Jennifer Wells +44 (0)20 7594 3328

 
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Location

 

154Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Posma:2020:10.1038/s43016-020-0093-y,
author = {Posma, JM and Garcia, Perez I and Frost, G and Aljuraiban, G and Chan, Q and Van, Horn L and Daviglus, M and Stamler, J and Holmes, E and Elliott, P and Nicholson, J},
doi = {10.1038/s43016-020-0093-y},
journal = {Nature Food},
pages = {426--436},
title = {Nutriome-metabolome relationships provide insights into dietary intake and metabolism},
url = {http://dx.doi.org/10.1038/s43016-020-0093-y},
volume = {1},
year = {2020}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Dietary assessment traditionally relies on self-reported data which are often inaccurate and may result in erroneous diet-disease risk associations. We illustrate how urinary metabolic phenotyping can be used as alternative approach for obtaining information on dietary patterns. We used two multi-pass 24-hr dietary recalls, obtained on two occasions on average three weeks apart, paired with two 24-hr urine collections from 1,848 U.S. individuals; 67 nutrients influenced the urinary metabotype measured with ¹H-NMR spectroscopy characterized by 46 structurally identified metabolites. We investigated the stability of each metabolite over time and showed that the urinary metabolic profile is more stable within individuals than reported dietary patterns. The 46 metabolites accurately predicted healthy and unhealthy dietary patterns in a free-living U.S. cohort and replicated in an independent U.K. cohort. We mapped these metabolites into a host-microbial metabolic network to identify key pathways and functions. These data can be used in future studies to evaluate how this set of diet-derived, stable, measurable bioanalytical markers are associated with disease risk. This knowledge may give new insights into biological pathways that characterize the shift from a healthy to unhealthy metabolic phenotype and hence give entry points for prevention and intervention strategies.
AU - Posma,JM
AU - Garcia,Perez I
AU - Frost,G
AU - Aljuraiban,G
AU - Chan,Q
AU - Van,Horn L
AU - Daviglus,M
AU - Stamler,J
AU - Holmes,E
AU - Elliott,P
AU - Nicholson,J
DO - 10.1038/s43016-020-0093-y
EP - 436
PY - 2020///
SN - 2662-1355
SP - 426
TI - Nutriome-metabolome relationships provide insights into dietary intake and metabolism
T2 - Nature Food
UR - http://dx.doi.org/10.1038/s43016-020-0093-y
UR - https://www.nature.com/articles/s43016-020-0093-y
UR - http://hdl.handle.net/10044/1/80099
VL - 1
ER -