Imperial College London

ProfessorPaulElliott

Faculty of MedicineSchool of Public Health

Chair in Epidemiology and Public Health Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3328p.elliott Website

 
 
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Assistant

 

Miss Jennifer Wells +44 (0)20 7594 3328

 
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Location

 

154Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Scott:2016:10.1371/journal.pone.0155478,
author = {Scott, WR and Zhang, W and Loh, M and Tan, S-T and Lehne, B and Afzal, U and Peralta, J and Saxena, R and Ralhan, S and Wander, GS and Bozaoglu, K and Sanghera, DK and Elliott, P and Scott, J and Chambers, JC and Kooner, JS},
doi = {10.1371/journal.pone.0155478},
journal = {PLOS One},
title = {Investigation of Genetic Variation Underlying Central Obesity amongst South Asians},
url = {http://dx.doi.org/10.1371/journal.pone.0155478},
volume = {11},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - ArticleAuthorsMetricsCommentsRelated ContentAbstractIntroductionMaterials and MethodsResultsDiscussion and ConclusionSupporting InformationAcknowledgmentsAuthor ContributionsReferencesReader Comments (0)Media Coverage (0)FiguresAbstractSouth Asians are 1/4 of the world’s population and have increased susceptibility to central obesity and related cardiometabolic disease. Knowledge of genetic variants affecting risk of central obesity is largely based on genome-wide association studies of common SNPs in Europeans. To evaluate the contribution of DNA sequence variation to the higher levels of central obesity (defined as waist hip ratio adjusted for body mass index, WHR) among South Asians compared to Europeans we carried out: i) a genome-wide association analysis of >6M genetic variants in 10,318 South Asians with focused analysis of population-specific SNPs; ii) an exome-wide association analysis of ~250K SNPs in protein-coding regions in 2,637 South Asians; iii) a comparison of risk allele frequencies and effect sizes of 48 known WHR SNPs in 12,240 South Asians compared to Europeans. In genome-wide analyses, we found no novel associations between common genetic variants and WHR in South Asians at P<5x10-8; variants showing equivocal association with WHR (P<1x10-5) did not replicate at P<0.05 in an independent cohort of South Asians (N = 1,922) or in published, predominantly European meta-analysis data. In the targeted analyses of 122,391 population-specific SNPs we also found no associations with WHR in South Asians at P<0.05 after multiple testing correction. Exome-wide analyses showed no new associations between genetic variants and WHR in South Asians, either individually at P<1.5x10-6 or grouped by gene locus at P<2.5x10−6. At known WHR loci, risk allele frequencies were not higher in South Asians compared to Europeans (P = 0.77), while effect sizes were unexpectedly smaller in South Asians than Europeans (P<5.0x10-8). Our find
AU - Scott,WR
AU - Zhang,W
AU - Loh,M
AU - Tan,S-T
AU - Lehne,B
AU - Afzal,U
AU - Peralta,J
AU - Saxena,R
AU - Ralhan,S
AU - Wander,GS
AU - Bozaoglu,K
AU - Sanghera,DK
AU - Elliott,P
AU - Scott,J
AU - Chambers,JC
AU - Kooner,JS
DO - 10.1371/journal.pone.0155478
PY - 2016///
SN - 1932-6203
TI - Investigation of Genetic Variation Underlying Central Obesity amongst South Asians
T2 - PLOS One
UR - http://dx.doi.org/10.1371/journal.pone.0155478
UR - http://hdl.handle.net/10044/1/33915
VL - 11
ER -