Imperial College London

ProfessorPaulElliott

Faculty of MedicineSchool of Public Health

Chair in Epidemiology and Public Health Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3328p.elliott Website

 
 
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Assistant

 

Miss Jennifer Wells +44 (0)20 7594 3328

 
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Location

 

154Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ehret:2016:10.1038/ng.3667,
author = {Ehret, GB and Ferreira, T and Chasman, DI and Jackson, AU and Schmidt, EM and Johnson, T and Thorleifsson, G and Luan, J and Donnelly, LA and Kanoni, S and Petersen, AK and Pihur, V and Strawbridge, RJ and Shungin, D and Hughes, MF and Meirelles, O and Kaakinen, M and Bouatia-Naji, N and Kristiansson, K and Shah, S and Kleber, ME and Guo, X and Lyytikäinen, LP and Fava, C and Eriksson, N and Nolte, IM and Magnusson, PK and Salfati, EL and Rallidis, LS and Theusch, E and Smith, AJ and Folkersen, L and Witkowska, K and Pers, TH and Joehanes, R and Kim, SK and Lataniotis, L and Jansen, R and Johnson, AD and Warren, H and Kim, YJ and Zhao, W and Wu, Y and Tayo, BO and Bochud, M and CHARGE-EchoGen, Consortium and CHARGE-HF, Consortium and Wellcome, Trust Case Control Consortium and Absher, D and Adair, LS and Amin, N and Arking, DE and Axelsson, T and Baldassarre, D and Balkau, B and Bandinelli, S and Barnes, MR and Barroso, I and Bevan, S and Bis, JC and Bjornsdottir, G and Boehnke, M and },
doi = {10.1038/ng.3667},
journal = {Nature Genetics},
pages = {1171--1184},
title = {The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals},
url = {http://dx.doi.org/10.1038/ng.3667},
volume = {48},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation.
AU - Ehret,GB
AU - Ferreira,T
AU - Chasman,DI
AU - Jackson,AU
AU - Schmidt,EM
AU - Johnson,T
AU - Thorleifsson,G
AU - Luan,J
AU - Donnelly,LA
AU - Kanoni,S
AU - Petersen,AK
AU - Pihur,V
AU - Strawbridge,RJ
AU - Shungin,D
AU - Hughes,MF
AU - Meirelles,O
AU - Kaakinen,M
AU - Bouatia-Naji,N
AU - Kristiansson,K
AU - Shah,S
AU - Kleber,ME
AU - Guo,X
AU - Lyytikäinen,LP
AU - Fava,C
AU - Eriksson,N
AU - Nolte,IM
AU - Magnusson,PK
AU - Salfati,EL
AU - Rallidis,LS
AU - Theusch,E
AU - Smith,AJ
AU - Folkersen,L
AU - Witkowska,K
AU - Pers,TH
AU - Joehanes,R
AU - Kim,SK
AU - Lataniotis,L
AU - Jansen,R
AU - Johnson,AD
AU - Warren,H
AU - Kim,YJ
AU - Zhao,W
AU - Wu,Y
AU - Tayo,BO
AU - Bochud,M
AU - CHARGE-EchoGen,Consortium
AU - CHARGE-HF,Consortium
AU - Wellcome,Trust Case Control Consortium
AU - Absher,D
AU - Adair,LS
AU - Amin,N
AU - Arking,DE
AU - Axelsson,T
AU - Baldassarre,D
AU - Balkau,B
AU - Bandinelli,S
AU - Barnes,MR
AU - Barroso,I
AU - Bevan,S
AU - Bis,JC
AU - Bjornsdottir,G
AU - Boehnke,M
AU - Boerwinkle,E
AU - Bonnycastle,LL
AU - Boomsma,DI
AU - Bornstein,SR
AU - Brown,MJ
AU - Burnier,M
AU - Cabrera,CP
AU - Chambers,JC
AU - Chang,IS
AU - Cheng,CY
AU - Chines,PS
AU - Chung,RH
AU - Collins,FS
AU - Connell,JM
AU - Döring,A
AU - Dallongeville,J
AU - Danesh,J
AU - de,Faire U
AU - Delgado,G
AU - Dominiczak,AF
AU - Doney,AS
AU - Drenos,F
AU - Edkins,S
AU - Eicher,JD
AU - Elosua,R
AU - Enroth,S
AU - Erdmann,J
AU - Eriksson,P
AU - Esko,T
AU - Evangelou,E
AU - Evans,A
AU - Fall,T
AU - Farrall,M
AU - Felix,JF
AU - Ferrières,J
AU - Ferrucci,L
AU - Fornage,M
AU - Forrester,T
AU - Franceschini,N
AU - Franco,OH
AU - Franco-Cereceda,A
AU - Fraser,RM
AU - Ganesh,SK
AU - Gao,H
AU - Gertow,K
AU - Gianfagna,F
AU - Gigante,B
AU - Giulianini,F
AU - Goel,A
AU - Goodall,AH
AU - Goodarzi,MO
AU - Gorski,M
AU - Gräßler,J
AU - Groves,CJ
AU - Gudnason,V
AU - Gyllensten,U
AU - Hallmans,G
AU - Hartikainen,AL
AU - Hassinen,M
AU - Havulinna,AS
AU - Hayward,C
AU - Hercberg,S
AU - Herzig,KH
AU - Hicks,AA
AU - Hingorani,AD
AU - Hirschhorn,JN
AU - Hofman,A
AU - Holmen,J
AU - Holmen,OL
AU - Hottenga,JJ
AU - Howard,P
AU - Hsiung,CA
AU - Hunt,SC
AU - Ikram,MA
AU - Illig,T
AU - Iribarren,C
AU - Jensen,RA
AU - Kähönen,M
AU - Kang,HM
AU - Kathiresan,S
AU - Keating,BJ
AU - Khaw,KT
AU - Kim,YK
AU - Kim,E
AU - Kivimaki,M
AU - Klopp,N
AU - Kolovou,G
AU - Komulainen,P
AU - Kooner,JS
AU - Kosova,G
AU - Krauss,RM
AU - Kuh,D
AU - Kutalik,Z
AU - Kuusisto,J
AU - Kvaløy,K
AU - Lakka,TA
AU - Lee,NR
AU - Lee,IT
AU - Lee,WJ
AU - Levy,D
AU - Li,X
AU - Liang,KW
AU - Lin,H
AU - Lin,L
AU - Lindström,J
AU - Lobbens,S
AU - Männistö,S
AU - Müller,G
AU - Müller-Nurasyid,M
AU - Mach,F
AU - Markus,HS
AU - Marouli,E
DO - 10.1038/ng.3667
EP - 1184
PY - 2016///
SN - 1546-1718
SP - 1171
TI - The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
T2 - Nature Genetics
UR - http://dx.doi.org/10.1038/ng.3667
UR - http://hdl.handle.net/10044/1/48175
VL - 48
ER -