Imperial College London


Faculty of MedicineSchool of Public Health

Chair in Epidemiology and Public Health Medicine



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Miss Jennifer Wells +44 (0)20 7594 3328




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BibTex format

author = {Schumann, G and Liu, C and O'Reilly, P and Gao, H and Song, P and Xu, B and Ruggeri, B and Amin, N and Jia, T and Preis, S and Segura, Lepe M and Akira, S and Barbieri, C and Baumeister, S and Cauchi, S and Clarke, TK and Enroth, S and Fischer, K and Hällfors, J and Harris, SE and Hieber, S and Hofer, E and Hottenga, JJ and Johansson, Å and Joshi, PK and Kaartinen, N and Laitinen, J and Lemaitre, R and Loukola, A and Luan, J and Lyytikäinen, LP and Mangino, M and Manichaikul, A and Mbarek, H and Milaneschi, Y and Moayyeri, A and Mukamal, K and Nelson, C and Nettleton, J and Partinen, E and Rawal, R and Robino, A and Rose, L and Sala, C and Satoh, T and Schmidt, R and Schraut, K and Scott, R and Smith, AV and Starr, JM and Teumer, A and Trompet, S and Uitterlinden, AG and Venturini, C and Vergnaud, AC and Verweij, N and Vitart, V and Vuckovic, D and Wedenoja, J and Yengo, L and Yu, B and Zhang, W and Zhao, JH and Boomsma, DI and Chambers, J and Chasman, DI and Daniela, T and de, Geus E },
doi = {10.1073/pnas.1611243113},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
pages = {14372--14377},
title = {KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference},
url = {},
volume = {113},
year = {2016}

RIS format (EndNote, RefMan)

AB - Alcohol is a widely consumed drug in western societies that can lead to addiction. A small shift in consumption can have dramatic consequences on public health. We performed the largest genome-wide association metaanalysis and replication study to date (>105,000 individuals) and identified a genetic basis for alcohol consumption during nonaddictive drinking. We found that a locus in the gene encoding β-Klotho is associated with alcohol consumption. β-Klotho is an essential receptor component for the endocrine FGFs, FGF19 and FGF21. Using mouse models and pharmacologic administration of FGF21, we show that β-Klotho in the brain controls alcohol drinking. These findings reveal a mechanism regulating alcohol consumption in humans that may be pharmacologically tractable for reducing alcohol intake.
AU - Schumann,G
AU - Liu,C
AU - O'Reilly,P
AU - Gao,H
AU - Song,P
AU - Xu,B
AU - Ruggeri,B
AU - Amin,N
AU - Jia,T
AU - Preis,S
AU - Segura,Lepe M
AU - Akira,S
AU - Barbieri,C
AU - Baumeister,S
AU - Cauchi,S
AU - Clarke,TK
AU - Enroth,S
AU - Fischer,K
AU - Hällfors,J
AU - Harris,SE
AU - Hieber,S
AU - Hofer,E
AU - Hottenga,JJ
AU - Johansson,Å
AU - Joshi,PK
AU - Kaartinen,N
AU - Laitinen,J
AU - Lemaitre,R
AU - Loukola,A
AU - Luan,J
AU - Lyytikäinen,LP
AU - Mangino,M
AU - Manichaikul,A
AU - Mbarek,H
AU - Milaneschi,Y
AU - Moayyeri,A
AU - Mukamal,K
AU - Nelson,C
AU - Nettleton,J
AU - Partinen,E
AU - Rawal,R
AU - Robino,A
AU - Rose,L
AU - Sala,C
AU - Satoh,T
AU - Schmidt,R
AU - Schraut,K
AU - Scott,R
AU - Smith,AV
AU - Starr,JM
AU - Teumer,A
AU - Trompet,S
AU - Uitterlinden,AG
AU - Venturini,C
AU - Vergnaud,AC
AU - Verweij,N
AU - Vitart,V
AU - Vuckovic,D
AU - Wedenoja,J
AU - Yengo,L
AU - Yu,B
AU - Zhang,W
AU - Zhao,JH
AU - Boomsma,DI
AU - Chambers,J
AU - Chasman,DI
AU - Daniela,T
AU - de,Geus E
AU - Deary,I
AU - Eriksson,JG
AU - Esko,T
AU - Eulenburg,V
AU - Franco,OH
AU - Froguel,P
AU - Gieger,C
AU - Grabe,HJ
AU - Gudnason,V
AU - Gyllensten,U
AU - Harris,TB
AU - Hartikainen,AL
AU - Heath,AC
AU - Hocking,L
AU - Hofman,A
AU - Huth,C
AU - Jarvelin,MR
AU - Jukema,JW
AU - Kaprio,J
AU - Kooner,JS
AU - Kutalik,Z
AU - Lahti,J
AU - Langenberg,C
AU - Lehtimäki,T
AU - Liu,Y
AU - Madden,PA
AU - Martin,N
AU - Morrison,A
AU - Penninx,B
AU - Pirastu,N
AU - Psaty,B
AU - Raitakari,O
AU - Ridker,P
AU - Rose,R
AU - Rotter,JI
AU - Samani,NJ
AU - Schmidt,H
AU - Spector,TD
AU - Stott,D
AU - Strachan,D
AU - Tzoulaki,I
AU - van,der Harst P
AU - van,Duijn CM
AU - Marques-Vidal,P
AU - Vollenweider,P
AU - Wareham,NJ
AU - Whitfield,JB
AU - Wilson,J
AU - Wolffenbuttel,B
AU - Bakalkin,G
AU - Evangelou,E
AU - Liu,Y
AU - Rice,KM
AU - Desrivières,S
AU - Kliewer,SA
AU - Mangelsdorf,DJ
AU - Müller,CP
AU - Levy,D
AU - Elliott,P
DO - 10.1073/pnas.1611243113
EP - 14377
PY - 2016///
SN - 1091-6490
SP - 14372
TI - KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
T2 - Proceedings of the National Academy of Sciences of the United States of America
UR -
UR -
UR -
VL - 113
ER -