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BibTex format

author = {Li, N and Yan, LL and Niu, W and Yao, C and Feng, X and Zhang, J and Shi, J and Zhang, Y and Zhang, R and Hao, Z and Chu, H and Zhang, J and Li, X and Pan, J and Li, Z and Sun, J and Zhou, B and Zhao, Y and Yu, Y and Engelgau, M and Labarthe, D and Ma, J and MacMahon, S and Elliott, P and Wu, Y and Neal, B},
doi = {10.1371/journal.pone.0166620},
journal = {PLOS One},
title = {The effects of a community-based sodium reduction program in rural china - a cluster-randomized trial},
url = {},
volume = {11},
year = {2016}

RIS format (EndNote, RefMan)

AB - BackgroundAverage sodium intake and stroke mortality in northern China are both among the highest in the world. An effective, low-cost strategy to reduce sodium intake in this population is urgently needed.ObjectiveWe sought to determine the effects of a community-based sodium reduction program on salt consumption in rural northern China.DesignThis study was a cluster-randomized trial done over 18 months in 120 townships (one village from each township) from five provinces. Sixty control villages were compared to 60 intervention villages that were given access to a reduced-sodium, added-potassium salt substitute in conjunction with a community-based health education program focusing on sodium reduction. The primary outcome was the difference in 24-hour urinary sodium excretion between randomized groups.ResultsAmong 1,903 people with valid 24-hour urine collections, mean urinary sodium excretion in intervention compared with control villages was reduced by 5.5% (-14mmol/day, 95% confidence interval -26 to -1; p = 0.03), potassium excretion was increased by 16% (+7mmol/day, +4 to +10; p<0.001), and sodium to potassium ratio declined by 15% (-0.9, -1.2 to -0.5; p<0.001). Mean blood pressure differences were -1.1 mm Hg systolic (-3.3 to +1.1; p = 0.33) and -0.7 mm Hg diastolic (-2.2 to +0.8, p = 0.35) and the difference in the proportion with hypertension was -1.3% (-5.1 to 2.5, p = 0.56).ConclusionThere were clear differences in population sodium and potassium intake between villages that were most likely a consequence of increased use of salt substitute. The absence of effects on blood pressure reflects the moderate changes in sodium and potassium intake achieved.Trial identifier: NCT01259700.
AU - Li,N
AU - Yan,LL
AU - Niu,W
AU - Yao,C
AU - Feng,X
AU - Zhang,J
AU - Shi,J
AU - Zhang,Y
AU - Zhang,R
AU - Hao,Z
AU - Chu,H
AU - Zhang,J
AU - Li,X
AU - Pan,J
AU - Li,Z
AU - Sun,J
AU - Zhou,B
AU - Zhao,Y
AU - Yu,Y
AU - Engelgau,M
AU - Labarthe,D
AU - Ma,J
AU - MacMahon,S
AU - Elliott,P
AU - Wu,Y
AU - Neal,B
DO - 10.1371/journal.pone.0166620
PY - 2016///
SN - 1932-6203
TI - The effects of a community-based sodium reduction program in rural china - a cluster-randomized trial
T2 - PLOS One
UR -
UR -
UR -
VL - 11
ER -