Imperial College London

ProfessorPaulElliott

Faculty of MedicineSchool of Public Health

Chair in Epidemiology and Public Health Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3328p.elliott Website

 
 
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Assistant

 

Miss Jennifer Wells +44 (0)20 7594 3328

 
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Location

 

154Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wahl:2016:10.1038/nature20784,
author = {Wahl, S and Drong, A and Lehne, B and Loh, M and Scott, WR and Kunze, S and Tsai, P-C and Ried, JS and Zhang, W and Yang, Y and Tan, S and Fiorito, G and Franke, L and Guarrera, S and Kasela, S and Kriebel, J and Richmond, RC and Adamo, M and Afzal, U and Ala-Korpela, M and Albetti, B and Ammerpohl, O and Apperley, JF and Beekman, M and Bertazzi, PA and Black, SL and Blancher, C and Bonder, M-J and Brosch, M and Carstensen-Kirberg, M and de, Craen AJM and de, Lusignan S and Dehghan, A and Elkalaawy, M and Fischer, K and Franco, OH and Gaunt, TR and Hampe, J and Hashemi, M and Isaacs, A and Jenkinson, A and Jha, S and Kato, N and Krogh, V and Laffan, M and Meisinger, C and Meitinger, T and Mok, ZY and Motta, V and Ng, HK and Nikolakopoulou, Z and Nteliopoulos, G and Panico, S and Pervjakova, N and Prokisch, H and Rathmann, W and Roden, M and Rota, F and Rozario, MA and Sandling, JK and Schafmayer, C and Schramm, K and Siebert, R and Slagboom, PE and Soininen, P and Stolk, L and Strauch,},
doi = {10.1038/nature20784},
journal = {Nature},
pages = {81--+},
title = {Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity},
url = {http://dx.doi.org/10.1038/nature20784},
volume = {541},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Approximately 1.5 billion people worldwide are overweight oraffected by obesity, and are at risk of developing type 2 diabetes,cardiovascular disease and related metabolic and inflammatorydisturbances1,2. Although the mechanisms linking adiposity toassociated clinical conditions are poorly understood, recent studiessuggest that adiposity may influence DNA methylation3–6, a keyregulator of gene expression and molecular phenotype7. Here weuse epigenome-wide association to show that body mass index(BMI; a key measure of adiposity) is associated with widespreadchanges in DNA methylation (187 genetic loci with P<1×10−7,range P=9.2×10−8 to 6.0×10−46; n=10,261 samples). Geneticassociation analyses demonstrate that the alterations in DNAmethylation are predominantly the consequence of adiposity,rather than the cause. We find that methylation loci are enrichedfor functional genomic features in multiple tissues (P<0.05), andshow that sentinel methylation markers identify gene expressionsignatures at 38 loci (P < 9.0 × 10−6, range P = 5.5 × 10−6 to6.1×10−35, n=1,785 samples). The methylation loci identify genesinvolved in lipid and lipoprotein metabolism, substrate transportand inflammatory pathways. Finally, we show that the disturbancesin DNA methylation predict future development of type 2 diabetes(relative risk per 1 standard deviation increase in methylation riskscore: 2.3 (2.07–2.56); P=1.1×10−54). Our results provide newinsights into the biologic pathways influenced by adiposity, and mayenable development of new strategies for prediction and preventionof type 2 diabetes and other adverse clinical consequences of obesity
AU - Wahl,S
AU - Drong,A
AU - Lehne,B
AU - Loh,M
AU - Scott,WR
AU - Kunze,S
AU - Tsai,P-C
AU - Ried,JS
AU - Zhang,W
AU - Yang,Y
AU - Tan,S
AU - Fiorito,G
AU - Franke,L
AU - Guarrera,S
AU - Kasela,S
AU - Kriebel,J
AU - Richmond,RC
AU - Adamo,M
AU - Afzal,U
AU - Ala-Korpela,M
AU - Albetti,B
AU - Ammerpohl,O
AU - Apperley,JF
AU - Beekman,M
AU - Bertazzi,PA
AU - Black,SL
AU - Blancher,C
AU - Bonder,M-J
AU - Brosch,M
AU - Carstensen-Kirberg,M
AU - de,Craen AJM
AU - de,Lusignan S
AU - Dehghan,A
AU - Elkalaawy,M
AU - Fischer,K
AU - Franco,OH
AU - Gaunt,TR
AU - Hampe,J
AU - Hashemi,M
AU - Isaacs,A
AU - Jenkinson,A
AU - Jha,S
AU - Kato,N
AU - Krogh,V
AU - Laffan,M
AU - Meisinger,C
AU - Meitinger,T
AU - Mok,ZY
AU - Motta,V
AU - Ng,HK
AU - Nikolakopoulou,Z
AU - Nteliopoulos,G
AU - Panico,S
AU - Pervjakova,N
AU - Prokisch,H
AU - Rathmann,W
AU - Roden,M
AU - Rota,F
AU - Rozario,MA
AU - Sandling,JK
AU - Schafmayer,C
AU - Schramm,K
AU - Siebert,R
AU - Slagboom,PE
AU - Soininen,P
AU - Stolk,L
AU - Strauch,K
AU - Tai,E-S
AU - Tarantini,L
AU - Thorand,B
AU - Tigchelaar,EF
AU - Tumino,R
AU - Uitterlinden,AG
AU - van,Duijn C
AU - van,Meurs JBJ
AU - Vineis,P
AU - Wickremasinghe,AR
AU - Wijmenga,C
AU - Yang,T-P
AU - Yuan,W
AU - Zhernakova,A
AU - Batterham,RL
AU - Smith,GD
AU - Deloukas,P
AU - Heijmans,BT
AU - Herder,C
AU - Hofman,A
AU - Lindgren,CM
AU - Milani,L
AU - van,der Harst P
AU - Peters,A
AU - Illig,T
AU - Relton,CL
AU - Waldenberger,M
AU - Jaervelin,M-R
AU - Bollati,V
AU - Soong,R
AU - Spector,TD
AU - Scott,J
AU - McCarthy,MI
AU - Elliott,P
AU - Bell,JT
AU - Matullo,G
AU - Gieger,C
AU - Kooner,JS
AU - Grallert,H
AU - Chambers,JC
DO - 10.1038/nature20784
EP - 81
PY - 2016///
SN - 0028-0836
SP - 81
TI - Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
T2 - Nature
UR - http://dx.doi.org/10.1038/nature20784
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000396119500033&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/49547
VL - 541
ER -