Publications
886 results found
Guo Z, Miura K, Turin TC, et al., 2010, Relationship of the Polyunsaturated to Saturated Fatty Acid Ratio to Cardiovascular Risk Factors and Metabolic Syndrome in Japanese: the INTERLIPID Study, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, Vol: 17, Pages: 777-784, ISSN: 1340-3478
- Author Web Link
- Cite
- Citations: 16
Tzoulaki I, Molokhia M, Curcin V, et al., 2009, Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database, BMJ-BRITISH MEDICAL JOURNAL, Vol: 339, ISSN: 1756-1833
- Author Web Link
- Cite
- Citations: 288
Zabaneh D, Chambers JC, Elliott P, et al., 2009, Heritability and genetic correlations of insulin resistance and component phenotypes in Asian Indian families using a multivariate analysis, DIABETOLOGIA, Vol: 52, Pages: 2585-2589, ISSN: 0012-186X
- Author Web Link
- Cite
- Citations: 27
Chambers J, Zhao J, Terracciano C, et al., 2009, Genetic Variation in SCN10a is Associated With Cardiac Conduction, Heart Block and Risk of Ventricular Fibrillation, 82nd Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S579-S580, ISSN: 0009-7322
Bonnefond A, Vaxillaire M, Labrune Y, et al., 2009, Genetic variant m HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits, Diabetes, Vol: 58, Pages: 2687-2697, ISSN: 0012-1797
OBJECTIVE A1C is widely considered the gold standard for monitoring effective blood glucose levels. Recently, a genome-wide association study reported an association between A1C and rs7072268 within HK1 (encoding hexokinase 1), which catalyzes the first step of glycolysis. HK1 deficiency in erythrocytes (red blood cells [RBCs]) causes severe nonspherocytic hemolytic anemia in both humans and mice.RESEARCH DESIGN AND METHODS The contribution of rs7072268 to A1C and the RBC-related traits was assessed in 6,953 nondiabetic European participants. We additionally analyzed the association with hematologic traits in 5,229 nondiabetic European individuals (in whom A1C was not measured) and 1,924 diabetic patients. Glucose control–related markers other than A1C were analyzed in 18,694 nondiabetic European individuals. A type 2 diabetes case-control study included 7,447 French diabetic patients.RESULTS Our study confirms a strong association between the rs7072268–T allele and increased A1C (β = 0.029%; P = 2.22 × 10−7). Surprisingly, despite adequate study power, rs7072268 showed no association with any other markers of glucose control (fasting- and 2-h post-OGTT–related parameters, n = 18,694). In contrast, rs7072268–T allele decreases hemoglobin levels (n = 13,416; β = −0.054 g/dl; P = 3.74 × 10−6) and hematocrit (n = 11,492; β = −0.13%; P = 2.26 × 10−4), suggesting a proanemic effect. The T allele also increases risk for anemia (836 cases; odds ratio 1.13; P = 0.018).CONCLUSIONS HK1 variation, although strongly associated with A1C, does not seem to be involved in blood glucose control. Since HK1 rs7072268 is associated with reduced hemoglobin levels and favors anemia, we propose that HK1 may influence A1C levels through its anemic effect or its effect on glucose metabolism in RBCs. These findings may have implications for type 2 diabetes diagnosis and clinical management because anemia i
Chambers JC, Zhang W, Zabaneh D, et al., 2009, Common genetic variation near melatonin receptor mtnr1b contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians, Diabetes, Vol: 58, Pages: 2703-2708, ISSN: 0012-1797
OBJECTIVE Fasting plasma glucose and risk of type 2 diabetes are higher among Indian Asians than among European and North American Caucasians. Few studies have investigated genetic factors influencing glucose metabolism among Indian Asians.RESEARCH DESIGN AND METHODS We carried out genome-wide association studies for fasting glucose in 5,089 nondiabetic Indian Asians genotyped with the Illumina Hap610 BeadChip and 2,385 Indian Asians (698 with type 2 diabetes) genotyped with the Illumina 300 BeadChip. Results were compared with findings in 4,462 European Caucasians.RESULTS We identified three single nucleotide polymorphisms (SNPs) associated with glucose among Indian Asians at P < 5 × 10−8, all near melatonin receptor MTNR1B. The most closely associated was rs2166706 (combined P = 2.1 × 10−9), which is in moderate linkage disequilibrium with rs1387153 (r2 = 0.60) and rs10830963 (r2 = 0.45), both previously associated with glucose in European Caucasians. Risk allele frequency and effect sizes for rs2166706 were similar among Indian Asians and European Caucasians: frequency 46.2 versus 45.0%, respectively (P = 0.44); effect 0.05 (95% CI 0.01–0.08) versus 0.05 (0.03–0.07 mmol/l), respectively, higher glucose per allele copy (P = 0.84). SNP rs2166706 was associated with type 2 diabetes in Indian Asians (odds ratio 1.21 [95% CI 1.06–1.38] per copy of risk allele; P = 0.006). SNPs at the GCK, GCKR, and G6PC2 loci were also associated with glucose among Indian Asians. Risk allele frequencies of rs1260326 (GCKR) and rs560887 (G6PC2) were higher among Indian Asians compared with European Caucasians.CONCLUSIONS Common genetic variation near MTNR1B influences blood glucose and risk of type 2 diabetes in Indian Asians. Genetic variation at the MTNR1B, GCK, GCKR, and G6PC2 loci may contribute to abnormal glucose metabolism and related metabolic disturbances among Indian Asians.
Toledano M, Bennett J, Molitor J, et al., 2009, Risk of Low Birth Weight in Relation to Trihalomethane Concentrations in Public Water Supply: A National Study Using Multiple Data Sources, 21st Annual Conference of the International-Society-for-Environmental-Epidemiology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S180-S181, ISSN: 1044-3983
Toledano MB, Bennett JE, Hambly P, et al., 2009, Chlorination Disinfection By-Products and Risk of Stillbirths in England and Wales, 21st Annual Conference of the International-Society-for-Environmental-Epidemiology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S129-S129, ISSN: 1044-3983
Chambers JC, Zhang W, Li Y, et al., 2009, Genome-wide association study identifies variants in <i>TMPRSS6</i> associated with hemoglobin levels, NATURE GENETICS, Vol: 41, Pages: 1170-1172, ISSN: 1061-4036
- Author Web Link
- Cite
- Citations: 188
Rung J, Cauchi S, Albrechtsen A, et al., 2009, Genetic variant near <i>IRS1</i> is associated with type 2 diabetes, insulin resistance and hyperinsulinemia, NATURE GENETICS, Vol: 41, Pages: 1110-U89, ISSN: 1061-4036
- Author Web Link
- Cite
- Citations: 329
Rung J, Cauchi S, Albrechtsen A, et al., 2009, Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia (vol 41, pg 1110, 2009), NATURE GENETICS, Vol: 41, Pages: 1156-1156, ISSN: 1061-4036
- Author Web Link
- Cite
- Citations: 2
Little MP, Tawn EJ, Tzoulaki I, et al., 2009, Comments: The non-cancer mortality experience of male workers at British Nuclear Fuels plc, 1946-2005., Int J Epidemiol, Vol: 38, Pages: 1159-1164, ISSN: 1464-3685
Stamler J, Brown IJ, Daviglus ML, et al., 2009, Glutamic Acid, the Main Dietary Amino Acid, and Blood Pressure The INTERMAP Study (International Collaborative Study of Macronutrients, Micronutrients and Blood Pressure), CIRCULATION, Vol: 120, Pages: 221-U115, ISSN: 0009-7322
- Author Web Link
- Cite
- Citations: 85
Elliott P, Chambers JC, Zhang W, et al., 2009, Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 302, Pages: 37-48, ISSN: 0098-7484
- Author Web Link
- Cite
- Citations: 485
Loo RL, Coen M, Ebbels T, et al., 2009, Metabolic Profiling and Population Screening of Analgesic Usage in Nuclear Magnetic Resonance Spectroscopy-Based Large-Scale Epidemiologic Studies, ANALYTICAL CHEMISTRY, Vol: 81, Pages: 5119-5129, ISSN: 0003-2700
- Author Web Link
- Cite
- Citations: 31
Kaspar H, Dettmer K, Chan Q, et al., 2009, Urinary amino acid analysis: A comparison of iTRAQ®-LC-MS/MS, GC-MS, and amino acid analyzer, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, Vol: 877, Pages: 1838-1846, ISSN: 1570-0232
- Author Web Link
- Cite
- Citations: 134
Lindgren CM, Heid IM, Randall JC, et al., 2009, Erratum., PLoS Genet, Vol: 5, ISSN: 1553-7404
[This corrects the article on p. e1000508 in vol. 5, PMID: 19557161.].
Smith LM, Maher AD, Want EJ, et al., 2009, Large-Scale Human Metabolic Phenotyping and Molecular Epidemiological Studies-via <SUP>1</SUP>H NMR Spectroscopy of Urine: Investigation of Borate Preservation, ANALYTICAL CHEMISTRY, Vol: 81, Pages: 4847-4856, ISSN: 0003-2700
- Author Web Link
- Cite
- Citations: 25
Chambers JC, Zhang W, Sehmi J, et al., 2009, COMMON GENETIC VARIATION NEAR MTNR1B CONTRIBUTES TO RAISED PLASMA GLUCOSE AND INCREASED RISK OF TYPE-2 DIABETES AMONG INDIAN ASIANS, Annual Scientific Conference of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A82-A82, ISSN: 1355-6037
Lindgren CM, Heid IM, Randall JC, et al., 2009, Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution, PLOS GENETICS, Vol: 5, ISSN: 1553-7404
- Author Web Link
- Open Access Link
- Cite
- Citations: 406
Schumann G, Lourdusamy A, Ducci F, et al., 2009, TRANSLATIONAL ANALYSIS STRATEGIES OF ALCOHOL WGAS, 32nd Annual Scientific Meeting of the Research-Society-on-Alcoholism, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 286A-286A, ISSN: 0145-6008
Elliott P, Chambers JC, Zhang W, et al., 2009, GENETIC LOCI INFLUENCING C-REACTIVE PROTEIN LEVELS AND CORONARY HEART DISEASE RISK: RESULTS OF GENETIC ASSOCIATION AND MENDELIAN RANDOMISATION STUDY WITH META-ANALYSIS IN 80 614 PEOPLE, Annual Scientific Conference of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A61-A61, ISSN: 1355-6037
Brown IJ, Tzoulaki I, Candeias V, et al., 2009, Salt intakes around the world: implications for public health, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 38, Pages: 791-813, ISSN: 0300-5771
- Author Web Link
- Cite
- Citations: 826
Freathy RM, Bennett AJ, Ring SM, et al., 2009, Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth, 58th Annual Meeting of the American-Society-of-Human-Genetics, Publisher: AMER DIABETES ASSOC, Pages: 1428-1433, ISSN: 0012-1797
- Author Web Link
- Cite
- Citations: 104
Vaarasmaki M, Pouta A, Elliot P, et al., 2009, Adolescent Manifestations of Metabolic Syndrome Among Children Born to Women With Gestational Diabetes in a General-Population Birth Cohort, AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol: 169, Pages: 1209-1215, ISSN: 0002-9262
- Author Web Link
- Cite
- Citations: 107
Newton-Cheh C, Johnson T, Gateva V, et al., 2009, Genome-wide association study identifies eight loci associated with blood pressure, Nature Genetics, Vol: 41, Pages: 666-676, ISSN: 1061-4036
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N ≤ 71,225 European ancestry, N ≤ 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10−24), CYP1A2 (P = 1 × 10−23), FGF5 (P = 1 × 10−21), SH2B3 (P = 3 × 10−18), MTHFR (P = 2 × 10−13), c10orf107 (P = 1 × 10−9), ZNF652 (P = 5 × 10−9) and PLCD3 (P = 1 × 10−8) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.
Newhouse S, Farrall M, Wallace C, et al., 2009, Polymorphisms in the WNK1 Gene Are Associated with Blood Pressure Variation and Urinary Potassium Excretion, PLOS One, Vol: 4, ISSN: 1932-6203
WNK1 - a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP) control - is an excellent candidategene for essential hypertension (EH). We and others have previously reported association between WNK1 and BP variation.Using tag SNPs (tSNPs) that capture 100% of common WNK1 variation in HapMap, we aimed to replicate our findings with BPand to test for association with phenotypes relating to WNK1 function in the British Genetics of Hypertension (BRIGHT) studycase-control resource (1700 hypertensive cases and 1700 normotensive controls). We found multiple variants to be associatedwith systolic blood pressure, SBP (7/28 tSNPs min-p = 0.0005), diastolic blood pressure, DBP (7/28 tSNPs min-p = 0.002) and24 hour urinary potassium excretion (10/28 tSNPs min-p = 0.0004). Associations with SBP and urine potassium remainedsignificant after correction for multiple testing (p = 0.02 and p = 0.01 respectively). The major allele (A) of rs765250, located inintron 1, demonstrated the strongest evidence for association with SBP, effect size 3.14 mmHg (95%CI:1.23–4.9), DBP 1.9 mmHg(95%CI:0.7–3.2) and hypertension, odds ratio (OR: 1.3 [95%CI: 1.0–1.7]).We genotyped this variant in six independentpopulations (n = 14,451) and replicated the association between rs765250 and SBP in a meta-analysis (p = 761023, combinedwith BRIGHT data-set p = 261024, n = 17,851). The associations of WNK1 with DBP and EH were not confirmed. Haplotypeanalysis revealed striking associations with hypertension and BP variation (global permutation p,1027). We identified severalcommon haplotypes to be associated with increased BP and multiple low frequency haplotypes significantly associated withlower BP (.10 mmHg reduction) and risk for hypertension (OR,0.60). Our data indicates that multiple rare and common WNK1variants contribute to BP variation and hypertension, and provide compelling evidence to initiate further genetic and functionalstudies to explore the role
Tzoulaki I, Abellan J, Fortunato L, et al., 2009, Deprivation and Regional Variation of Cardiovascular and All-Cause Mortality Across England: A Small Area Comparison, Joint Nutrition, Physical Activity and Metabolism Conference/49th Cardiovascular Disease Epidemiology and Prevention of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: E280-E280, ISSN: 0009-7322
Sovio U, Bennett AJ, Millwood IY, et al., 2009, Genetic Determinants of Height Growth Assessed Longitudinally from Infancy to Adulthood in the Northern Finland Birth Cohort 1966, PLOS Genetics, Vol: 5, ISSN: 1553-7390
Recent genome-wide association (GWA) studies have identified dozens of common variants associated with adult height. However, it is unknown how these variants influence height growth during childhood. We derived peak height velocity in infancy (PHV1) and puberty (PHV2) and timing of pubertal height growth spurt from parametric growth curves fitted to longitudinal height growth data to test their association with known height variants. The study consisted of N = 3,538 singletons from the prospective Northern Finland Birth Cohort 1966 with genotype data and frequent height measurements (on average 20 measurements per person) from 0–20 years. Twenty-six of the 48 variants tested associated with adult height (p<0.05, adjusted for sex and principal components) in this sample, all in the same direction as in previous GWA scans. Seven SNPs in or near the genes HHIP, DLEU7, UQCC, SF3B4/SV2A, LCORL, and HIST1H1D associated with PHV1 and five SNPs in or near SOCS2, SF3B4/SV2A, C17orf67, CABLES1, and DOT1L with PHV2 (p<0.05). We formally tested variants for interaction with age (infancy versus puberty) and found biologically meaningful evidence for an age-dependent effect for the SNP in SOCS2 (p = 0.0030) and for the SNP in HHIP (p = 0.045). We did not have similar prior evidence for the association between height variants and timing of pubertal height growth spurt as we had for PHVs, and none of the associations were statistically significant after correction for multiple testing. The fact that in this sample, less than half of the variants associated with adult height had a measurable effect on PHV1 or PHV2 is likely to reflect limited power to detect these associations in this dataset. Our study is the first genetic association analysis on longitudinal height growth in a prospective cohort from birth to adulthood and gives grounding for future research on the genetic regulation of human height during different periods of growth.
Vineis P, Elliott P, 2009, Why is epidemiology necessary to policy-making?, JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, Vol: 63, Pages: 186-187, ISSN: 0143-005X
- Author Web Link
- Cite
- Citations: 2
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.