Imperial College London
Alternate

ProfessorPaulElliott

Faculty of Medicine, School of Public Health

Chair in Epidemiology and Public Health Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3328p.elliott Website

 
 
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Assistant

 

Miss Jennifer Wells +44 (0)20 7594 3328

 
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Location

 

154Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{de:2020:10.1038/s41380-020-0719-3,
author = {de, las Fuentes L and Sung, YJ and Noordam, R and Winkler, T and Feitosa, MF and Schwander, K and Bentley, AR and Brown, MR and Guo, X and Manning, A and Chasman, DI and Aschard, H and Bartz, TM and Bielak, LF and Campbell, A and Cheng, C-Y and Dorajoo, R and Hartwig, FP and Horimoto, ARVR and Li, C and Li-Gao, R and Liu, Y and Marten, J and Musani, SK and Ntalla, I and Rankinen, T and Richard, M and Sim, X and Smith, AV and Tajuddin, SM and Tayo, BO and Vojinovic, D and Warren, HR and Xuan, D and Alver, M and Boissel, M and Chai, J-F and Chen, X and Christensen, K and Divers, J and Evangelou, E and Gao, C and Girotto, G and Harris, SE and He, M and Hsu, F-C and Kuehnel, B and Laguzzi, F and Li, X and Lyytikainen, L-P and Nolte, IM and Poveda, A and Rauramaa, R and Riaz, M and Rueedi, R and Shu, X-O and Snieder, H and Sofer, T and Takeuchi, F and Verweij, N and Ware, EB and Weiss, S and Yanek, LR and Amin, N and Arking, DE and Arnett, DK and Bergmann, S and Boerwinkle, E and Brody, JA },
doi = {10.1038/s41380-020-0719-3},
journal = {Molecular Psychiatry},
pages = {2111--2125},
title = {Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci},
url = {http://dx.doi.org/10.1038/s41380-020-0719-3},
volume = {26},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, “Some College” (yes/no) and “Graduated College” (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects. Analyses were performed for systolic BP, diastolic BP, mean arterial pressure, and pulse pressure. We pursued genome-wide interrogation in Stage 1 studies (N = 117 438) and follow-up on promising variants in Stage 2 studies (N = 293 787) in five ancestry groups. Through combined meta-analyses of Stages 1 and 2, we identified 84 known and 18 novel BP loci at genome-wide significance level (P < 5 × 10-8). Two novel loci were identified based on the 1DF test of interaction with educational attainment, while the remaining 16 loci were identified through the 2DF joint test of genetic and interaction effects. Ten novel loci were identified in individuals of African ancestry. Several novel loci show strong biological plausibility since they involve physiologic systems implicated in BP regulation. They include genes involved in the central nervous system-adrenal signaling axis (ZDHHC17, CADPS, PIK3C2G), vascular structure and function (GNB3, CDON), and renal function (HAS2 and HAS2-AS1, SLIT3). Collectively, these findings suggest a role of educational attainment or SES in further dissection of the genetic architecture of BP.
AU  - de,las Fuentes L
AU  - Sung,YJ
AU  - Noordam,R
AU  - Winkler,T
AU  - Feitosa,MF
AU  - Schwander,K
AU  - Bentley,AR
AU  - Brown,MR
AU  - Guo,X
AU  - Manning,A
AU  - Chasman,DI
AU  - Aschard,H
AU  - Bartz,TM
AU  - Bielak,LF
AU  - Campbell,A
AU  - Cheng,C-Y
AU  - Dorajoo,R
AU  - Hartwig,FP
AU  - Horimoto,ARVR
AU  - Li,C
AU  - Li-Gao,R
AU  - Liu,Y
AU  - Marten,J
AU  - Musani,SK
AU  - Ntalla,I
AU  - Rankinen,T
AU  - Richard,M
AU  - Sim,X
AU  - Smith,AV
AU  - Tajuddin,SM
AU  - Tayo,BO
AU  - Vojinovic,D
AU  - Warren,HR
AU  - Xuan,D
AU  - Alver,M
AU  - Boissel,M
AU  - Chai,J-F
AU  - Chen,X
AU  - Christensen,K
AU  - Divers,J
AU  - Evangelou,E
AU  - Gao,C
AU  - Girotto,G
AU  - Harris,SE
AU  - He,M
AU  - Hsu,F-C
AU  - Kuehnel,B
AU  - Laguzzi,F
AU  - Li,X
AU  - Lyytikainen,L-P
AU  - Nolte,IM
AU  - Poveda,A
AU  - Rauramaa,R
AU  - Riaz,M
AU  - Rueedi,R
AU  - Shu,X-O
AU  - Snieder,H
AU  - Sofer,T
AU  - Takeuchi,F
AU  - Verweij,N
AU  - Ware,EB
AU  - Weiss,S
AU  - Yanek,LR
AU  - Amin,N
AU  - Arking,DE
AU  - Arnett,DK
AU  - Bergmann,S
AU  - Boerwinkle,E
AU  - Brody,JA
AU  - Broeckel,U
AU  - Brumat,M
AU  - Burke,G
AU  - Cabrera,CP
AU  - Canouil,M
AU  - Chee,ML
AU  - Chen,Y-DI
AU  - Cocca,M
AU  - Connell,J
AU  - de,Silva HJ
AU  - de,Vries PS
AU  - Eiriksdottir,G
AU  - Faul,JD
AU  - Fisher,V
AU  - Forrester,T
AU  - Fox,EF
AU  - Friedlander,Y
AU  - Gao,H
AU  - Gigante,B
AU  - Giulianini,F
AU  - Gu,CC
AU  - Gu,D
AU  - Harris,TB
AU  - He,J
AU  - Heikkinen,S
AU  - Heng,C-K
AU  - Hunt,S
AU  - Ikram,MA
AU  - Irvin,MR
AU  - Kahonen,M
AU  - Kavousi,M
AU  - Khor,CC
AU  - Kilpelainen,TO
AU  - Koh,W-P
AU  - Komulainen,P
AU  - Kraja,AT
AU  - Krieger,JE
AU  - Langefeld,CD
AU  - Li,Y
AU  - Liang,J
AU  - Liewald,DCM
AU  - Liu,C-T
AU  - Liu,J
AU  - Lohman,KK
AU  - Magi,R
AU  - McKenzie,CA
AU  - Meitinger,T
AU  - Metspalu,A
AU  - Milaneschi,Y
AU  - Milani,L
AU  - Mook-Kanamori,DO
AU  - Nalls,MA
AU  - Nelson,CP
AU  - Norris,JM
AU  - O'Connell,J
AU  - Ogunniyi,A
AU  - Padmanabhan,S
AU  - Palmer,ND
AU  - Pedersen,NL
AU  - Perls,T
AU  - Peters,A
AU  - Petersmann,A
AU  - Peyser,PA
AU  - Polasek,O
AU  - Porteous,DJ
AU  - Raffel,LJ
AU  - Rice,TK
AU  - Rotter,JI
AU  - Rudan,I
AU  - Rueda-Ochoa,O-L
AU  - Sabanayagam,C
AU  - Salako,BL
AU  - Schreiner,PJ
AU  - Shikany,JM
AU  - Sidney,SS
AU  - Sims,M
AU  - Sitlani,CM
AU  - Smith,JA
AU  - Starr,JM
AU  - Strauch,K
AU  - Swertz,MA
AU  - Teumer,A
AU  - Tham,YC
AU  - Uitterlinden,AG
AU  - Vaidya,D
AU  - van,der Ende MY
AU  - Waldenberger,M
AU  - Wang,L
AU  - Wang,Y-X
AU  - Wei,W-B
AU  - Weir,DR
AU  - Wen,W
AU  - Yao,J
AU  - Yu,B
AU  - Yu,C
AU  - Yuan,J-M
AU  - Zhao,W
AU  - Zonderman,AB
AU  - Becker,DM
AU  - Bowden,DW
AU  - Deary,IJ
AU  - Doerr,M
AU  - Esko,T
AU  - Freedman,BI
AU  - Froguel,P
AU  - Gasparini,P
AU  - Gieger,C
AU  - Jonas,JB
AU  - Kammerer,CM
AU  - Kato,N
AU  - Lakka,TA
AU  - Leander,K
AU  - Lehtimaki,T
AU  - Magnusson,PKE
AU  - Marques-Vidal,P
AU  - Penninx
DO  - 10.1038/s41380-020-0719-3
EP  - 2125
PY  - 2020///
SN  - 1359-4184
SP  - 2111
TI  - Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci
T2  - Molecular Psychiatry
UR  - http://dx.doi.org/10.1038/s41380-020-0719-3
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000530592500002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41380-020-0719-3
UR  - http://hdl.handle.net/10044/1/79827
VL  - 26
ER  -
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