Imperial College London
Alternate

ProfessorPaulElliott

Faculty of Medicine, School of Public Health

Chair in Epidemiology and Public Health Medicine
 
 
 
//

Contact

 

+44 (0)20 7594 3328p.elliott Website

 
 
//

Assistant

 

Miss Jennifer Wells +44 (0)20 7594 3328

 
//

Location

 

154Norfolk PlaceSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Huang:2020:10.1212/WNL.0000000000010463,
author = {Huang, J and Zuber, V and Matthews, P and Tzoulaki, I and Elliott, P and Dehghan, A},
doi = {10.1212/WNL.0000000000010463},
journal = {Neurology},
title = {Sleep, major depressive disorder and Alzheimer’s disease: a Mendelian randomisation study},
url = {http://dx.doi.org/10.1212/WNL.0000000000010463},
volume = {95},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectiveTo explore the causal relationships between sleep, major depressive disorder (MDD), and Alzheimer’s disease (AD).MethodsWe conducted bi-directional two-sample Mendelian randomisation analyses. Genetic associations were obtained from the largest genome-wide association studies currently available in UK Biobank (N=446,118), the Psychiatric Genomics Consortium (N=18,759), and the International Genomics of Alzheimer’s Project (N=63,926). We used the inverse variance weighted Mendelian randomisation method to estimate causal effects, and weighted median and MR-Egger for sensitivity analyses to test for pleiotropic effects. ResultsWe found that higher risk of AD was significantly associated with being a “morning person” (odds ratio (OR)=1.01, P=0.001), shorter sleep duration (self-reported: β=-0.006, P=1.9×10-4; accelerometer-based: β=-0.015, P=6.9×10-5), less likely to report long sleep (β=-0.003, P=7.3×10-7), earlier timing of the least active 5 hours (β=-0.024, P=1.7×10-13), and a smaller number of sleep episodes (β=-0.025, P=5.7×10-14) after adjusting for multiple comparisons. We also found that higher risk of AD was associated with lower risk of insomnia (OR=0.99, P=7×10-13). However, we did not find evidence either that these abnormal sleep patterns were causally related to AD or for a significant causal relationship between MDD and risk of AD. ConclusionWe found that AD may causally influence sleep patterns. However, we did not find evidence supporting a causal role of disturbed sleep patterns for AD or evidence for a causal relationship between MDD and AD.
AU  - Huang,J
AU  - Zuber,V
AU  - Matthews,P
AU  - Tzoulaki,I
AU  - Elliott,P
AU  - Dehghan,A
DO  - 10.1212/WNL.0000000000010463
PY  - 2020///
SN  - 0028-3878
TI  - Sleep, major depressive disorder and Alzheimer’s disease: a Mendelian randomisation study
T2  - Neurology
UR  - http://dx.doi.org/10.1212/WNL.0000000000010463
UR  - http://hdl.handle.net/10044/1/80967
VL  - 95
ER  -
Download