Imperial College London
Alternate

ProfessorPaulElliott

Faculty of Medicine, School of Public Health

Chair in Epidemiology and Public Health Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3328p.elliott Website

 
 
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Assistant

 

Miss Jennifer Wells +44 (0)20 7594 3328

 
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Location

 

154Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chadeau:2020:10.1016/j.eclinm.2020.100658,
author = {Chadeau, M and Bodinier, B and Vermeulen, R and Karimi, M and Zuber, V and Castagne, R and Elliott, J and Muller, D and Petrovic, D and Whitaker, M and Stringhini, S and Tzoulaki, I and Kivimaki, M and Vineis, P and Elliott, P and Kelly-Irving, M and Delpierre, C},
doi = {10.1016/j.eclinm.2020.100658},
journal = {EClinicalMedicine},
title = {Education, biological ageing, all-cause and cause-specific mortality and morbidity: UK Biobank Cohort Study},
url = {http://dx.doi.org/10.1016/j.eclinm.2020.100658},
volume = {29-30},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundSocioeconomic position as measured by education may be embodied and affect the functioning of key physiological systems. Links between social disadvantage, its biological imprint, and cause-specific mortality and morbidity have not been investigated in large populations, and yet may point towards areas for public health interventions beyond targeting individual behaviours.MethodsUsing data from 366,748 UK Biobank participants with 13 biomarker measurements, we calculated a Biological Health Score (BHS, ranging from 0 to 1) capturing the level of functioning of five physiological systems. Associations between BHS and incidence of cardiovascular disease (CVD) and cancer, and mortality from all, CVD, cancer, and external causes were examined. We explored the role of education in these associations. Mendelian randomisation using genetic evidence was used to triangulate these findings.FindingsAn increase in BHS of 0.1 was associated with all-cause (HR = 1.14 [1.12–1.16] and 1.09 [1.07–1.12] in men and women respectively), cancer (HR = 1.11 [1.09–1.14] and 1.07 [1.04–1.10]) and CVD (HR = 1.25 [1.20–1.31] and 1.21 [1.11–1.31]) mortality, CVD incidence (HR = 1.15 [1.13–1.16] and 1.17 [1.15–1.19]). These associations survived adjustment for education, lifestyle-behaviours, body mass index (BMI), co-morbidities and medical treatments. Mendelian randomisation further supported the link between the BHS and CVD incidence (HR = 1.31 [1.21–1.42]). The BHS contributed to CVD incidence prediction (age-adjusted C-statistic = 0.58), other than through education and health behaviours.InterpretationThe BHS captures features of the embodiment of education, health behaviours, and more proximal unknown factors which all complementarily contribute to all-cause, cancer and CVD morbidity and premature death.
AU  - Chadeau,M
AU  - Bodinier,B
AU  - Vermeulen,R
AU  - Karimi,M
AU  - Zuber,V
AU  - Castagne,R
AU  - Elliott,J
AU  - Muller,D
AU  - Petrovic,D
AU  - Whitaker,M
AU  - Stringhini,S
AU  - Tzoulaki,I
AU  - Kivimaki,M
AU  - Vineis,P
AU  - Elliott,P
AU  - Kelly-Irving,M
AU  - Delpierre,C
DO  - 10.1016/j.eclinm.2020.100658
PY  - 2020///
SN  - 2589-5370
TI  - Education, biological ageing, all-cause and cause-specific mortality and morbidity: UK Biobank Cohort Study
T2  - EClinicalMedicine
UR  - http://dx.doi.org/10.1016/j.eclinm.2020.100658
UR  - http://hdl.handle.net/10044/1/85368
VL  - 29-30
ER  -
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