Imperial College London
Alternate

ProfessorPaulElliott

Faculty of Medicine, School of Public Health

Chair in Epidemiology and Public Health Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3328p.elliott Website

 
 
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Assistant

 

Miss Jennifer Wells +44 (0)20 7594 3328

 
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Location

 

154Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yang:2021:ajcn/nqaa430,
author = {Yang, JJ and Tzoulaki, I and Karaman, I and Elliott, P and Yu, D},
doi = {ajcn/nqaa430},
journal = {American Journal of Clinical Nutrition},
pages = {1145--1156},
title = {Circulating trimethylamine N-oxide (TMAO) in association with diet and cardiometabolic biomarkers: an international pooled analysis},
url = {http://dx.doi.org/10.1093/ajcn/nqaa430},
volume = {113},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Trimethylamine N-oxide (TMAO), a diet-derived, gut microbial-host co-metabolite, has been linked to cardiometabolic diseases. However, the relationships remain unclear between diet, TMAO, and cardiometabolic health in general populations from different regions and ethnicities. Objective: To examine associations of circulating TMAO with dietary and cardiometabolic factors in a pooled analysis of 16 population-based studies from the US, Europe, and Asia.Design: Included were 32,166 adults (16,269 White, 13,293 Asian, 1,247 Hispanic/Latino, and 1,236 Black) without cardiovascular disease, cancer, chronic kidney disease, or inflammatory bowel disease. Linear regression coefficients (β) were computed for standardized TMAO with harmonized variables. Study-specific results were combined by random-effects meta-analysis. False discovery rate<0.10 was considered significant. Results: After adjustment for potential confounders, circulating TMAO was associated with intakes of animal protein and saturated fat (β=0.124 and 0.058, respectively, for 5%-energy increase) and with shellfish, total fish, eggs, and red meat (β=0.370, 0.151, 0.081, and 0.056, respectively, for 1-serving/day increase). Plant protein and nuts showed inverse associations (β=-0.126 for 5%-energy increase from plant protein and -0.123 for 1-serving/day of nuts). Although the animal protein-TMAO association was consistent across populations, fish and shellfish associations were stronger among Asians (β=0.285 and 0.578), and egg and red meat associations were more prominent among Americans (β=0.153 and 0.093). Besides, circulating TMAO was positively associated with creatinine (β=0.131 per standard deviation increase in log-TMAO), homocysteine (β=0.065), insulin (β=0.048), HbA1c (β=0.048), and glucose (β=0.023), while inversely associated with HDL-cholesterol (β=-0.047) and blood pressure (β=-0.030). Each TMAO-biomarker association
AU  - Yang,JJ
AU  - Tzoulaki,I
AU  - Karaman,I
AU  - Elliott,P
AU  - Yu,D
DO  - ajcn/nqaa430
EP  - 1156
PY  - 2021///
SN  - 0002-9165
SP  - 1145
TI  - Circulating trimethylamine N-oxide (TMAO) in association with diet and cardiometabolic biomarkers: an international pooled analysis
T2  - American Journal of Clinical Nutrition
UR  - http://dx.doi.org/10.1093/ajcn/nqaa430
UR  - https://academic.oup.com/ajcn/article/113/5/1145/6214421
UR  - http://hdl.handle.net/10044/1/86226
VL  - 113
ER  -
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