Imperial College London
Alternate

ProfessorPaulElliott

Faculty of Medicine, School of Public Health

Chair in Epidemiology and Public Health Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3328p.elliott Website

 
 
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Assistant

 

Miss Jennifer Wells +44 (0)20 7594 3328

 
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Location

 

154Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Evangelou:2021:10.1101/2021.01.20.21249931,
author = {Evangelou, E and Suzuki, H and Bai, W and Pazoki, R and Gao, H and Matthews, PM and Elliott, P},
doi = {10.1101/2021.01.20.21249931},
title = {Alcohol consumption is associated with structural changes in various organ systems: A population-based study in UK Biobank},
url = {http://dx.doi.org/10.1101/2021.01.20.21249931},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Excessive alcohol consumption is associated with damage to various organs, but its multi-organ effects have not been characterised across the usual range of alcohol drinking in a large general population sample. We assessed global effects of alcohol consumption on quantitative magnetic resonance imaging phenotypic measures of the brain, heart, aorta and liver of UK-Biobank participants who reported drinking alcohol. We found a monotonic association of higher alcohol consumption with lower normalised brain volume across the range of alcohol intakes (–1.7×10<jats:sup>−3</jats:sup>±0.76×10<jats:sup>−3</jats:sup> per doubling of alcohol consumption, <jats:italic>P</jats:italic>=3.0×10<jats:sup>−14</jats:sup>). Alcohol consumption also was associated directly with measures of left ventricular mass index and left ventricular and atrial volume indices. Liver fat increased by a mean of 0.15% per doubling of alcohol consumption. Our results imply that there is not a “safe threshold” below which there are no toxic effects of alcohol. Current public health guidelines concerning alcohol consumption may need to be revisited.</jats:p>
AU  - Evangelou,E
AU  - Suzuki,H
AU  - Bai,W
AU  - Pazoki,R
AU  - Gao,H
AU  - Matthews,PM
AU  - Elliott,P
DO  - 10.1101/2021.01.20.21249931
PY  - 2021///
TI  - Alcohol consumption is associated with structural changes in various organ systems: A population-based study in UK Biobank
UR  - http://dx.doi.org/10.1101/2021.01.20.21249931
ER  -
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