Imperial College London
Alternate

ProfessorPaulElliott

Faculty of Medicine, School of Public Health

Chair in Epidemiology and Public Health Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3328p.elliott Website

 
 
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Assistant

 

Miss Jennifer Wells +44 (0)20 7594 3328

 
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Location

 

154Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Karabegović:2021:10.1038/s41467-021-22752-6,
author = {Karabegovi, I and Dehghan, A and Elliott, P and Vineis, P and Ghanbari, M},
doi = {10.1038/s41467-021-22752-6},
journal = {Nature Communications},
title = {Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption},
url = {http://dx.doi.org/10.1038/s41467-021-22752-6},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is consistently linked to, among others, reduced risk of diabetes and liver diseases; however, the mechanisms of action remain elusive. Epigenetics is suggested as a mechanism mediating the effects of dietary and lifestyle factors on disease onset. Here we report the results from epigenome-wide association studies (EWAS) on coffee and tea consumption in 15,789 participants of European and African-American ancestries from 15 cohorts. EWAS meta-analysis of coffee consumption reveals 11 CpGs surpassing the epigenome-wide significance threshold (P-value <1.1×10−7), which annotated to the AHRR, F2RL3, FLJ43663, HDAC4, GFI1 and PHGDH genes. Among them, cg14476101 is significantly associated with expression of the PHGDH and risk of fatty liver disease. Knockdown of PHGDH expression in liver cells shows a correlation with expression levels of genes associated with circulating lipids, suggesting a role of PHGDH in hepatic-lipid metabolism. EWAS meta-analysis on tea consumption reveals no significant association, only two CpGs annotated to CACNA1A and PRDM16 genes show suggestive association (P-value <5.0×10−6). These findings indicate that coffee-associated changes in DNA methylation levels may explain the mechanism of action of coffee consumption in conferring risk of diseases.
AU  - Karabegovi,I
AU  - Dehghan,A
AU  - Elliott,P
AU  - Vineis,P
AU  - Ghanbari,M
DO  - 10.1038/s41467-021-22752-6
PY  - 2021///
SN  - 2041-1723
TI  - Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-021-22752-6
UR  - http://hdl.handle.net/10044/1/89164
VL  - 12
ER  -
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