Summary
I am a Senior Image Processing and Data Scientist based at the Cardiovascular Magnetic Resonance unit, Royal Brompton Hospital. I have a background in Physics and Mathematics, a PhD in MRI Physics (Imperial College :: London), and an extensive experience in MRI research.
Since 2012, I have been working closely with a team of physicists and clinicians in diffusion tensor cardiovascular magnetic resonance (DT-CMR). It is a novel technique for the investigation of the 3-dimensional microstructure of the heart in-vivo. We aim to improve the understanding of how the healthy heart functions as well as how microstructural dysfunction contributes to disease.
I am focused on creating specialised tools to perform data analysis, image processing, and data visualisation, with a recent interest in finding solutions with AI.
Highlights
We developed and validated a fully automated postprocessing framework for in vivo diffusion tensor cardiac magnetic resonance (DT-CMR) data powered by deep learning semantic segmentation (TensorFlow):
We published in vivo studies showing that secondary directions of diffusion align with the laminar organisation of cardiomyocytes in the heart, and that cardiomyopathy hearts present impaired mobility:
- Ferreira, P. F., Kilner, P. J., McGill, L.A., et al. In vivo cardiovascular magnetic resonance diffusion tensor imaging shows evidence of abnormal myocardial laminar orientations and mobility in hypertrophic cardiomyopathy. J Cardiovasc Magn Reson (2014): 87. 2015 winner of the SCMR Gerald Pohost best manuscript award.
- Nielles-Vallespin, S., Khalique, Z., Ferreira, P. F., et al. Assessment of Myocardial Microstructural Dynamics by In Vivo Diffusion Tensor Cardiac Magnetic Resonance. J Am Coll Cardiol (2017): 661-676. 2017. Orloff Science Award (NIH, Bethesda MD, USA)
Previous academic education:
- 2005 - 2009: PhD in Myocardial Perfusion Imaging with MR, Imperial College, London, UK.
- 2004 - 2005: MSc in Medical Engineering and Physics, King’s College, University of London, UK.
- 1998 - 2004: First Degree in Physics / Applied Mathematics (Astrophysics), Faculty of Sciences, University of Porto, Portugal.
Publications
Journals
Teh I, Romero W, Boyle J, et al. , 2022, Validation of cardiac diffusion tensor imaging sequences: A multi-centre test-retest phantom study, Nmr in Biomedicine, Vol:35, ISSN:0952-3480, Pages:1-18
Ferreira PF, Banerjee A, Scott AD, et al. , 2022, Accelerating Cardiac Diffusion Tensor Imaging With a U-Net Based Model: Toward Single Breath-Hold, Journal of Magnetic Resonance Imaging, Vol:56, ISSN:1053-1807, Pages:1691-1704
Auger DA, Ghadimi S, Cai X, et al. , 2022, Reproducibility of global and segmental myocardial strain using cine DENSE at 3 T: a multicenter cardiovascular magnetic resonance study in healthy subjects and patients with heart disease, Journal of Cardiovascular Magnetic Resonance, Vol:24, ISSN:1097-6647, Pages:23-23
Dwornik M, Khalique Z, Rajakulasingam R, et al. , 2022, Cardiovascular Magnetic Resonance in Cardiomyopathy, International Journal of Cardiodiabetes
Scott A, Jackson T, Khalique Z, et al. , 2022, Development of a CMR compatible large animal isolated heart model for direct comparison of beating and arrested hearts, Nmr in Biomedicine, Vol:35, ISSN:0952-3480