Imperial College London
Portrait Picture

DrPedroFerreira

Faculty of Medicine, National Heart & Lung Institute

Honorary Research Fellow
 
 
 
//

Contact

 

p.f.ferreira05

 
 
//

Location

 

Sydney StreetRoyal Brompton Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Zheng:2023:10.1007/s10237-023-01721-6,
author = {Zheng, Y and Chan, WX and Nielles-Vallespin, S and Scott, AD and Ferreira, PF and Leo, HL and Yap, CH},
doi = {10.1007/s10237-023-01721-6},
journal = {Biomechanics and Modeling in Mechanobiology},
pages = {1313--1332},
title = {Effects of myocardial sheetlet sliding on left ventricular function},
url = {http://dx.doi.org/10.1007/s10237-023-01721-6},
volume = {22},
year = {2023}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Left ventricle myocardium has a complex micro-architecture, which was revealed to consist of myocyte bundles arranged in a series of laminar sheetlets. Recent imaging studies demonstrated that these sheetlets re-orientated and likely slided over each other during the deformations between systole and diastole, and that sheetlet dynamics were altered during cardiomyopathy. However, the biomechanical effect of sheetlet sliding is not well-understood, which is the focus here. We conducted finite element simulations of the left ventricle (LV) coupled with a windkessel lumped parameter model to study sheetlet sliding, based on cardiac MRI of a healthy human subject, and modifications to account for hypertrophic and dilated geometric changes during cardiomyopathy remodeling. We modeled sheetlet sliding as a reduced shear stiffness in the sheet-normal direction and observed that (1) the diastolic sheetlet orientations must depart from alignment with the LV wall plane in order for sheetlet sliding to have an effect on cardiac function, that (2) sheetlet sliding modestly aided cardiac function of the healthy and dilated hearts, in terms of ejection fraction, stroke volume, and systolic pressure generation, but its effects were amplified during hypertrophic cardiomyopathy and diminished during dilated cardiomyopathy due to both sheetlet angle configuration and geometry, and that (3) where sheetlet sliding aided cardiac function, it increased tissue stresses, particularly in the myofibre direction. We speculate that sheetlet sliding is a tissue architectural adaptation to allow easier deformations of the LV walls so that LV wall stiffness will not hinder function, and to provide a balance between function and tissue stresses. A limitation here is that sheetlet sliding is modeled as a simple reduction in shear stiffness, without consideration of micro-scale sheetlet mechanics and dynamics.
AU  - Zheng,Y
AU  - Chan,WX
AU  - Nielles-Vallespin,S
AU  - Scott,AD
AU  - Ferreira,PF
AU  - Leo,HL
AU  - Yap,CH
DO  - 10.1007/s10237-023-01721-6
EP  - 1332
PY  - 2023///
SN  - 1617-7940
SP  - 1313
TI  - Effects of myocardial sheetlet sliding on left ventricular function
T2  - Biomechanics and Modeling in Mechanobiology
UR  - http://dx.doi.org/10.1007/s10237-023-01721-6
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000982780800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://link.springer.com/article/10.1007/s10237-023-01721-6
UR  - http://hdl.handle.net/10044/1/107412
VL  - 22
ER  -
Download