Imperial College London
Portrait Picture

ProfessorPaulFarrell

Faculty of Medicine, Department of Infectious Disease

Professor of Tumour Virology
 
 
 
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Contact

 

+44 (0)20 7594 2005p.farrell Website

 
 
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Location

 

Section of VirologyNorfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

164 results found

de Jesus O, Smith PR, Spender LC, Karstegl CE, Niller HH, Huang D, Farrell PJet al., 2003, Updated Epstein-Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV, JOURNAL OF GENERAL VIROLOGY, Vol: 84, Pages: 1443-1450, ISSN: 0022-1317

Journal article

Bergamaschi D, Gasco M, Hiller L, Sullivan A, Syed N, Trigiante G, Yulug I, Merlano M, Numico G, Comino A, Attard M, Reelfs O, Gusterson B, Bell AK, Heath V, Tavassoli M, Farrell PJ, Smith P, Lu X, Crook Tet al., 2003, p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis, CANCER CELL, Vol: 3, Pages: 387-402, ISSN: 1535-6108

Journal article

Bryant H, Farrell PJ, 2002, Signal transduction and transcription factor modification during reactivation of Epstein-Barr virus from latency, JOURNAL OF VIROLOGY, Vol: 76, Pages: 10290-10298, ISSN: 0022-538X

Journal article

Binné UK, Amon W, Farrell PJ, 2002, Promoter sequences required for reactivation of Epstein-Barr virus from latency, JOURNAL OF VIROLOGY, Vol: 76, Pages: 10282-10289, ISSN: 0022-538X

Journal article

Farrell PJ, 2002, Tumour viruses - could they be an Achilles' heel of cancer?, EUROPEAN JOURNAL OF CANCER, Vol: 38, Pages: 1815-1816, ISSN: 0959-8049

Journal article

Farrell PJ, 2002, Cell-switching and kissing, NATURE MEDICINE, Vol: 8, Pages: 559-560, ISSN: 1078-8956

Journal article

Spender LC, Cornish GH, Sullivan A, Farrell PJet al., 2002, Expression of transcription factor AML-2 (RUNX3, CBFα-3) is induced by Epstein-Barr virus EBNA-2 and correlates with the B-cell activation phenotype, JOURNAL OF VIROLOGY, Vol: 76, Pages: 4919-4927, ISSN: 0022-538X

Journal article

Gasco M, Bell AK, Heath V, Sullivan A, Smith P, Hiller L, Yulug I, Numico G, Merlano M, Farrell PJ, Tavassoli M, Gusterson B, Crook Tet al., 2002, Epigenetic inactivation of 14-3-3 σ in oral carcinoma:: Association with p16<SUP>INK4a</SUP> silencing and human papillomavirus negativity, CANCER RESEARCH, Vol: 62, Pages: 2072-2076, ISSN: 0008-5472

Journal article

Gasco M, Sullivan A, Repellin C, Brooks L, Farrell PJ, Tidy JA, Dunne B, Gusterson B, Evans DJ, Crook Tet al., 2002, Coincident inactivation of 14-3-3σ and p16<SUP>INK4a</SUP> is an early event in vulval squamous neoplasia, ONCOGENE, Vol: 21, Pages: 1876-1881, ISSN: 0950-9232

Journal article

Reddy A, Yuille M, Sullivan A, Repellin C, Bell A, Tidy JA, Evans DJ, Farrell PJ, Gusterson B, Gasco M, Crook Tet al., 2002, Analysis of CHK2 in vulval neoplasia, BRITISH JOURNAL OF CANCER, Vol: 86, Pages: 756-760, ISSN: 0007-0920

Journal article

Sullivan A, Yuille M, Repellin C, Reddy A, Reelfs O, Bell A, Dunne B, Gusterson BA, Osin P, Farrell PJ, Yulug I, Evans A, Ozcelik T, Gasco M, Crook Tet al., 2002, Concomitant inactivation of p53 and Chk2 in breast cancer, ONCOGENE, Vol: 21, Pages: 1316-1324, ISSN: 0950-9232

Journal article

Brooks LA, Sullivan A, O'Nions J, Bell A, Dunne B, Tidy JA, Evans DJ, Osin P, Vousden KH, Gusterson B, Farrell PJ, Storey A, Gasco M, Sakai T, Crook Tet al., 2002, E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia, BRITISH JOURNAL OF CANCER, Vol: 86, Pages: 263-268, ISSN: 0007-0920

Journal article

Brooks LA, Sullivan A, O'Nions J, Bell A, Dunne B, Tidy JA, Evans DJ, Osin P, Vousden KH, Gusterson B, Farrell PJ, Storey A, Gasco M, Sakai T, Crook Tet al., 2002, E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia., Br J Cancer, Vol: 86, Pages: 263-268, ISSN: 0007-0920

In common with other E2F1 responsive genes such as p14(ARF) and B-myb, the promoter of p73 is shown to be positively regulated in cell lines and primary human keratinocytes by E7 proteins from oncogenic human papillomavirus (HPV) types 16, 18, 31 and 33, but not HPV 6. Mutational analysis revealed that transactivation of the p73 promoter by HPV 16E7 requires association with pRb. Expression of p73 in normal cervical epithelium is confined to the basal and supra-basal layers. In contrast, expression in neoplastic lesions is detected throughout the epithelium and increases with grade of neoplasia, being maximal in squamous cell cancers (SCC). Deregulation of expression of the N-terminal splice variant p73Delta2 was observed in a significant proportion of cancers, but not in normal epithelium. The frequent over-expression of p73Delta2, which has recognized transdominant properties, in malignant and pre-malignant lesions suggests a role in the oncogenic process in cervical epithelium.

Journal article

Mundodi V, Somanna A, Farrell PJ, Gedamu Let al., 2002, Genomic organization and functional expression of differentially regulated <i>cysteine protease</i> genes of <i>Leishmania donovani</i> complex, GENE, Vol: 282, Pages: 257-265, ISSN: 0378-1119

Journal article

O'Nions J, Brooks LA, Sullivan A, Bell A, Dunne B, Rozycka M, Reddy A, Tidy JA, Evans D, Farrell PJ, Evans A, Gasco M, Gusterson B, Crook Tet al., 2001, p73 is over-expressed in vulval cancer principally as the Δ2 isoform, BRITISH JOURNAL OF CANCER, Vol: 85, Pages: 1551-1556, ISSN: 0007-0920

Journal article

Wensing B, Stühler A, Jenkins P, Hollyoake M, Karstegl CE, Farrell PJet al., 2001, Variant chromatin structure of the <i>oriP</i> region of Epstein-Barr virus and regulation of EBER1 expression by upstream sequences and <i>oriP</i>, JOURNAL OF VIROLOGY, Vol: 75, Pages: 6235-6241, ISSN: 0022-538X

Journal article

Spender LC, Cornish GH, Rowland B, Kempkes B, Farrell PJet al., 2001, Direct and indirect regulation of cytokine and cell cycle proteins by EBNA-2 during Epstein-Barr virus infection, JOURNAL OF VIROLOGY, Vol: 75, Pages: 3537-3546, ISSN: 0022-538X

Journal article

Inman GJ, Binné UK, Parker GA, Farrell PJ, Allday MJet al., 2001, Activators of the Epstein-Barr virus lytic program concomitantly induce apoptosis, but lytic gene expression protects from cell death, JOURNAL OF VIROLOGY, Vol: 75, Pages: 2400-2410, ISSN: 0022-538X

Journal article

Farrell PJ, 2001, Epstein-Barr virus. The B95-8 strain map., Methods Mol Biol, Vol: 174, Pages: 3-12, ISSN: 1064-3745

Journal article

Sashegyi AI, Brown KS, Farrell PJ, 2000, Application of a generalized random effects regression model for cluster-correlated longitudinal data to a school-based smoking prevention trial, AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol: 152, Pages: 1192-1200, ISSN: 0002-9262

Journal article

Brooks LA, Tidy JA, Gusterson B, Hiller L, O'Nions J, Gasco M, Marin MC, Farrell PJ, Kaelin WG, Crook Tet al., 2000, Preferential retention of codon 72 arginine p53 in squamous cell carcinomas of the vulva occurs in cancers positive and negative for human papillomavirus, CANCER RESEARCH, Vol: 60, Pages: 6875-6877, ISSN: 0008-5472

Journal article

Smith PR, de Jesus O, Turner D, Hollyoake M, Karstegl CE, Griffin BE, Karran L, Wang YL, Hayward SD, Farrell PJet al., 2000, Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus, JOURNAL OF VIROLOGY, Vol: 74, Pages: 3082-3092, ISSN: 0022-538X

Journal article

Jenkins PJ, Binné UK, Farrell PJ, 2000, Histone acetylation and reactivation of Epstein-Barr virus from latency, JOURNAL OF VIROLOGY, Vol: 74, Pages: 710-720, ISSN: 0022-538X

Journal article

Wensing B, Farrell PJ, 2000, Regulation of cell growth and death by Epstein-Barr virus, MICROBES AND INFECTION, Vol: 2, Pages: 77-84, ISSN: 1286-4579

Journal article

Kiermaier A, Gawn JM, Desbarats L, Saffrich R, Ansorge W, Farrell PJ, Eilers M, Packham Get al., 1999, DNA binding of USF is required for specific E-box dependent gene activation <i>in vivo</i>, ONCOGENE, Vol: 18, Pages: 7200-7211, ISSN: 0950-9232

Journal article

Spender LC, Cannell EJ, Hollyoake M, Wensing B, Gawn JM, Brimmell M, Packham G, Farrell PJet al., 1999, Control of cell cycle entry and apoptosis in B lymphocytes infected by Epstein-Barr virus, JOURNAL OF VIROLOGY, Vol: 73, Pages: 4678-4688, ISSN: 0022-538X

Journal article

Cannell EJ, Farrell PJ, Sinclair AJ, 1998, Cell cycle arrest following exposure of EBV-immortalised B-cells to gamma irradiation correlates with inhibition of cdk2 activity, FEBS LETTERS, Vol: 439, Pages: 297-301, ISSN: 0014-5793

Journal article

Farrell PJ, 1998, Signal transduction from the Epstein-Barr virus LMP-1 transforming protein, TRENDS IN MICROBIOLOGY, Vol: 6, Pages: 175-177, ISSN: 0966-842X

Journal article

Cludts I, Farrell PJ, 1998, Multiple functions within the Epstein-Barr virus EBNA-3A protein, JOURNAL OF VIROLOGY, Vol: 72, Pages: 1862-1869, ISSN: 0022-538X

Journal article

Radkov SA, Bain M, Farrell PJ, West M, Rowe M, Allday MJet al., 1997, Epstein-Barr virus EBNA3C represses Cp, the major promoter for EBNA expression, but has no effect on the promoter of the cell gene CD21, JOURNAL OF VIROLOGY, Vol: 71, Pages: 8552-8562, ISSN: 0022-538X

Journal article

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