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@article{Wongwiwat:2022:10.1128/jvi.00394-22,
author = {Wongwiwat, W and Fournier, B and Bassano, I and Bayoumy, A and Elgueta, Karstegl C and Styles, C and Bridges, R and Lenoir, C and BoutBoul, D and Moshous, D and Neven, B and Kanda, T and Morgan, R and White, R and Latour, S and Farrell, P},
doi = {10.1128/jvi.00394-22},
journal = {Journal of Virology},
pages = {1--15},
title = {Epstein-Barr virus genome deletions in Epstein-Barr virus-positive T/NK cell lymphoproliferative diseases},
url = {http://dx.doi.org/10.1128/jvi.00394-22},
volume = {96},
year = {2022}
}

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TY  - JOUR
AB  - The main target cells for Epstein-Barr virus (EBV) infection and persistence are B lymphocytes, although T and NK cells can also become infected. In this paper we characterise the EBV present in 21 pediatric and adult patients treated in France for a range of diseases that involve infection of T or NK cells. Of these 21 cases, 5 pediatric patients (21%) and 11 adult patients (52%) are of Caucasian origin. In about 30% of the cases, some of the EBV genomes contain a large deletion. The deletions are different in every patient but tend to cluster near the BART region of the viral genome. Detailed investigation of a family, in which several members have persistent T or NK cell infection by EBV, indicates that the virus genome deletions arise or are selected independently in each individual patient. Genome sequence polymorphisms in the EBV in these T or NK cell diseases reflect the geographic origin of the patient, not a distinct type of EBV (the 21 cases studied included examples of both type 1 and type 2 EBV infection). Using virus produced from type 1 or type 2 EBV genomes cloned in bacterial artificial chromosome (BAC) vectors, we demonstrate infection of T cells in cord blood from healthy donors. Our results are consistent with transient infection of some T cells being part of normal asymptomatic infection by EBV in young children.
AU  - Wongwiwat,W
AU  - Fournier,B
AU  - Bassano,I
AU  - Bayoumy,A
AU  - Elgueta,Karstegl C
AU  - Styles,C
AU  - Bridges,R
AU  - Lenoir,C
AU  - BoutBoul,D
AU  - Moshous,D
AU  - Neven,B
AU  - Kanda,T
AU  - Morgan,R
AU  - White,R
AU  - Latour,S
AU  - Farrell,P
DO  - 10.1128/jvi.00394-22
EP  - 15
PY  - 2022///
SN  - 0022-538X
SP  - 1
TI  - Epstein-Barr virus genome deletions in Epstein-Barr virus-positive T/NK cell lymphoproliferative diseases
T2  - Journal of Virology
UR  - http://dx.doi.org/10.1128/jvi.00394-22
UR  - https://journals.asm.org/doi/epub/10.1128/jvi.00394-22
UR  - http://hdl.handle.net/10044/1/96848
VL  - 96
ER  -

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