Imperial College London


Faculty of MedicineDepartment of Infectious Disease

Chair in Protein Crystallography



+44 (0)20 7594 5327p.freemont




259Sir Alexander Fleming BuildingSouth Kensington Campus





Professor Freemont is Head of the Section of Structural and Synthetic Biology in the Department of Infectious Disease at Imperial College. The Section is based in South Kensington Sir Alexander Fleming Building and focuses on the molecular mechanisms of human disease and infection using the tools of integrated structural biology comprising X-ray crystallography, Cryo-EM and associated biophysical, spectroscopic and cellular techniques. The Section is also leading the London Consortium for Cryo-EM (LonCEM) with partners Kings College, Institute of Cancer Research, Queen Mary University and the Francis Crick Institute. In addition the Section also has research programs  in synthetic biology focused on automation, cell free systems, microbiome engineering, low cost viral and pathogenic biosensors and novel natural product discovery. Please go to the Structural and Synthetic Biology Section website  for news, up-to-date research summaries, a list of job opportunities, and information on lab members.

Professor Freemont is also co-founder of the Imperial College Centre for Synthetic Biology (2009) and co-founder/co-director of the National UK Innovation and Knowledge Centre for Synthetic Biology (SynbiCITE; since Oct 2013) at Imperial College London. The Centre aims to enable synthetic biology research in application areas like biosensors,  biosynthesis, bioprocessing and metabolic and genome engineering and enable the translation of new synthetic biology technologies into start-ups, SME's and industry.  Previous to this he was head of the Division of Molecular Biosciences at Imperial (now the Department of Life Sciences), and head of the Centre for Structural Biology having joined Imperial from Cancer Research UK London Research Institute (now known as the Francis Crick Institute) where he was a Principal Scientist. His research interests span from understanding  molecular mechanisms associated with human disease and infection using structural molecular biology techniques to the development of synthetic biology cell-free and platform technologies for healthcare applications.



Crone MA, Freemont PS, 2022, Simple low-cost production of DNA MS2 virus-like particles as molecular diagnostic controls, Gen Biotechnology, Vol:1, ISSN:2768-1556, Pages:496-503

Haines MC, Carling B, Marshall J, et al., 2022, basicsynbio and the BASIC SEVA collection: software and vectors for an established DNA assembly method, Synthetic Biology, Vol:7, ISSN:2397-7000

Patchsung M, Homchan A, Aphicho K, et al., 2022, A multiplexed Cas13-based assay with point-of-care attributes for simultaneous COVID-19 diagnosis and variant surveillance, The Crispr Journal, ISSN:2573-1599, Pages:1-17

Moore SJ, Lai H-E, Li J, et al., 2022, Streptomyces cell-free systems for natural product discovery and engineering., Nat Prod Rep

Mercer T, Almond N, Crone MA, et al., 2022, The Coronavirus Standards Working Group's roadmap for improved population testing, Nature Biotechnology, Vol:40, ISSN:1087-0156, Pages:1563-1568

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