Imperial College London
Professor Philippe Froguel

ProfessorPhilippeFroguel

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Genomic Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6520p.froguel

 
 
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Assistant

 

Mrs Patricia Murphy +44 (0)20 7594 1603

 
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Location

 

E306Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

1181 results found

Talbot F, Feetham CH, Mokrosinski J, Lawler K, Keogh JM, Henning E, de Oliveira EM, Ayinampudi V, Saeed S, Bonnefond A, Arslan M, Yeo GSH, Froguel P, Bechtold DA, Adamson A, Humphreys N, Barroso I, Luckman SM, Farooqi ISet al., 2023, A rare human variant that disrupts GPR10 signalling causes weight gain in mice, NATURE COMMUNICATIONS, Vol: 14

Journal article

Bonnefond A, Unnikrishnan R, Doria A, Vaxillaire M, Kulkarni RN, Mohan V, Trischitta V, Froguel Pet al., 2023, Monogenic diabetes, NATURE REVIEWS DISEASE PRIMERS, Vol: 9, ISSN: 2056-676X

Journal article

Kahoul Y, Yao X, Oger F, Moreno M, Amanzougarene S, Derhourhi M, Durand E, Boutry R, Bonnefond A, Froguel P, Dani C, Annicotte J-S, Breton Cet al., 2023, Knocking Down <i>CDKN2A</i> in 3D hiPSC-Derived Brown Adipose Progenitors Potentiates Differentiation, Oxidative Metabolism and Browning Process, CELLS, Vol: 12

Journal article

Folon L, Baron M, Toussaint B, Vaillant E, Boissel M, Scherrer V, Loiselle H, Leloire A, Badreddine A, Balkau B, Charpentier G, Franc S, Marre M, Aboulouard S, Salzet M, Canouil M, Derhourhi M, Froguel P, Bonnefond Aet al., 2023, Contribution of heterozygous <i>PCSK1</i> variants to obesity and implications for precision medicine: a case-control study, LANCET DIABETES & ENDOCRINOLOGY, Vol: 11, Pages: 182-190, ISSN: 2213-8587

Journal article

Allesoe RL, Lundgaard AT, Medina RH, Aguayo-Orozco A, Johansen J, Nissen JN, Brorsson C, Mazzoni G, Niu L, Biel JH, Brasas V, Webel H, Benros ME, Pedersen AG, Chmura PJ, Jacobsen UP, Mari A, Koivula R, Mahajan A, Vinuela A, Tajes JF, Sharma S, Haid M, Hong M-G, Musholt PB, De Masi F, Vogt J, Pedersen HK, Gudmundsdottir V, Jones A, Kennedy G, Bell J, Thomas EL, Frost G, Thomsen H, Hansen E, Hansen TH, Vestergaard H, Muilwijk M, Blom MT, Hart LMT, Pattou F, Raverdy V, Brage S, Kokkola T, Heggie A, McEvoy D, Mourby M, Kaye J, Hattersley A, McDonald T, Ridderstrale M, Walker M, Forgie I, Giordano GN, Pavo I, Ruetten H, Pedersen O, Hansen T, Dermitzakis E, Franks PW, Schwenk JM, Adamski J, McCarthy M, Pearson E, Banasik K, Rasmussen S, Brunak Set al., 2023, Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models, NATURE BIOTECHNOLOGY, Vol: 41, Pages: 399-+, ISSN: 1087-0156

Journal article

Delannoy CP, Heuson E, Herledan A, Oger F, Thiroux B, Chevalier M, Gromada X, Rolland L, Froguel P, Deprez B, Paul S, Annicotte J-Set al., 2023, High-Throughput Quantitative Screening of Glucose-Stimulated Insulin Secretion and Insulin Content Using Automated MALDI-TOF Mass Spectrometry, CELLS, Vol: 12

Journal article

Saeed S, Manzoor J, Khanam R, Janjua QM, Ning L, Ayesha H, Khan WI, Hanook S, Bonnefond A, Butt TA, Arslan M, Froguel Pet al., 2023, High Mortality and Morbidity of Leptin Signalling Deficiency - A Consanguineous Population, Publisher: KARGER, ISSN: 0250-6807

Conference paper

Froguel P, Bonnefond A, 2023, Advances and promises of personalized precision medicine for metabolic diseases: Precision metabolic medicine, BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE, Vol: 207, Pages: 199-203, ISSN: 0001-4079

Journal article

Froguel P, Ning L, Boissel M, Usman M, Khanam R, Manzoor J, Badreddine A, Janjua QM, Toussaint B, Vaillant E, Amanzougarene S, Canouil M, Derhourhi M, Farooqi IS, Bonnefond A, Arslan M, Saeed Set al., 2023, centric Analysis Revealed a Novel Cause of Syndromic Obesity in Severely Obese Consanguineous Families, Publisher: KARGER, ISSN: 0250-6807

Conference paper

Dawed AY, Mari A, Brown A, McDonald TJ, Li L, Wang S, Hong M-G, Sharma S, Robertson NR, Mahajan A, Wang X, Walker M, Gough S, Hart LMT, Zhou K, Forgie I, Ruetten H, Pavo I, Bhatnagar P, Jones AG, Pearson ER, DIRECT consortium FTDIRECTCet al., 2023, Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials, LANCET DIABETES & ENDOCRINOLOGY, Vol: 11, Pages: 33-41, ISSN: 2213-8587

Journal article

Froguel P, Bonnefond A, 2022, The discovery of human agouti-induced obesity and its implication for genetic diagnosis, NATURE METABOLISM, Vol: 4, Pages: 1614-1615

Journal article

Corniere N, Thomson RB, Thauvin S, Villoutreix BO, Karp S, Dynia DW, Burlein S, Brinkmann L, Badreddine A, Dechaume A, Derhourhi M, Durand E, Vaillant E, Froguel P, Chambrey R, Aronson PS, Bonnefond A, Eladari Det al., 2022, Dominant negative mutation in oxalate transporter <i>SLC26A6</i> associated with enteric hyperoxaluria and nephrolithiasis, JOURNAL OF MEDICAL GENETICS, Vol: 59, Pages: 1035-1043, ISSN: 0022-2593

Journal article

Pupko I, Demirkan A, Zudina L, Balkhiyarova Z, Ulrich A, Pascat V, Maina J, Froguel P, Kaakinen M, Prokopenko Iet al., 2022, Multi-phenotype GWAS Uncovers Shared Genetic Loci between Type 2 Diabetes, BMI, Colorectal, Pancreatic, Breast and Prostate Cancers, Annual Meeting of the International-Genetic-Epidemiology-Society (IGES), Publisher: WILEY, Pages: 525-526, ISSN: 0741-0395

Conference paper

Pervjakova N, Moen G-H, Borges M-C, Ferreira T, Cook JP, Allard C, Beaumont RN, Canouil M, Hatem G, Heiskala A, Joensuu A, Karhunen V, Kwak SH, Lin FTJ, Liu J, Rifas-Shiman S, Tam CH, Tam WH, Thorleifsson G, Andrew T, Auvinen J, Bhowmik B, Bonnefond A, Delahaye F, Demirkan A, Froguel P, Haller-Kikkatalo K, Hardardottir H, Hummel S, Hussain A, Kajantie E, Keikkala E, Khamis A, Lahti J, Lekva T, Mustaniemi S, Sommer C, Tagoma A, Tzala E, Uibo R, Vaarasmaki M, Villa PM, Birkeland K, Bouchard L, Duijn CM, Finer S, Groop L, Hamalainen E, Hayes GM, Hitman GA, Jang HC, Jarvelin M-R, Jenum AK, Laivuori H, Ma RC, Melander O, Oken E, Park KS, Perron P, Prasad RB, Qvigstad E, Sebert S, Stefansson K, Steinthorsdottir V, Tuomi T, Hivert M-F, Franks PW, McCarthy M, Lindgren CM, Freathy RM, Lawlor DA, Morris AP, Magi Ret al., 2022, Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes, HUMAN MOLECULAR GENETICS, Vol: 31, Pages: 3377-3391, ISSN: 0964-6906

Journal article

Young WJ, Lahrouchi N, Isaacs A, Duong TV, Foco L, Ahmed F, Brody JA, Salman R, Noordam R, Benjamins J-W, Haessler J, Lyytikainen L-P, Repetto L, Concas MP, van den Berg ME, Weiss S, Baldassari AR, Bartz TM, Cook JP, Evans DS, Freudling R, Hines O, Isaksen JL, Lin H, Mei H, Moscati A, Mueller-Nurasyid M, Nursyifa C, Qian Y, Richmond A, Roselli C, Ryan KA, Tarazona-Santos E, Theriault S, van Duijvenboden S, Warren HR, Yao J, Raza D, Aeschbacher S, Ahlberg G, Alonso A, Andreasen L, Bis JC, Boerwinkle E, Campbell A, Catamo E, Cocca M, Cutler MJ, Darbar D, De Grandi A, De Luca A, Ding J, Ellervik C, Ellinor PT, Felix SB, Froguel P, Fuchsberger C, Gogele M, Graff C, Graff M, Guo X, Hansen T, Heckbert SR, Huang PL, Huikuri H, Hutri-Kahonen N, Ikram MA, Jackson RD, Junttila J, Kavousi M, Kors JA, Leal TP, Lemaitre RN, Lin HJ, Lind L, Linneberg A, Liu S, MacFarlane PW, Mangino M, Meitinger T, Mezzavilla M, Mishra PP, Mitchell RN, Mononen N, Montasser ME, Morrison AC, Nauck M, Nauffal V, Navarro P, Nikus K, Pare G, Patton KK, Pelliccione G, Pittman A, Porteous DJ, Pramstaller PP, Preuss MH, Raitakari OT, Reiner AP, Ribeiro ALP, Rice KM, Risch L, Schlessinger D, Schotten U, Schurmann C, Shen X, Shoemaker MB, Sinagra G, Sinner MF, Soliman EZ, Stoll M, Strauch K, Tarasov K, Taylor KD, Tinker A, Trompet S, Uitterlinden A, Voelker U, Voelzke H, Waldenberger M, Weng L-C, Whitsel EA, Wilson JG, Avery CL, Conen D, Correa A, Cucca F, Dorr M, Gharib SA, Girotto G, Grarup N, Hayward C, Jamshidi Y, Jarvelin M-R, Jukema JW, Kaab S, Kahonen M, Kanters JK, Kooperberg C, Lehtimaki T, Lima-Costa MF, Liu Y, Loos RJF, Lubitz SA, Mook-Kanamori DO, Morris AP, O'Connell JR, Olesen MS, Orini M, Padmanabhan S, Pattaro C, Peters A, Psaty BM, Rotter J, Stricker B, van der Harst P, van Duijn CM, Verweij N, Wilson JF, Arking DE, Ramirez J, Lambiase PD, Sotoodehnia N, Mifsud B, Newton-Cheh C, Munroe PBet al., 2022, Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways, NATURE COMMUNICATIONS, Vol: 13

Journal article

Folon L, Baron M, Derhourhi M, Balkau B, Charpentier G, Franc S, Roussel R, Canouil M, Froguel P, Bonnefond Aet al., 2022, Impact of rare heterozygous mutations of PCSK1 on obesity: implication for treatment with MC4R agonists, Publisher: SPRINGER, Pages: S33-S34, ISSN: 0012-186X

Conference paper

Hu M, Kim I, Canouil M, Bonas-Guarch S, Khamis AA, Ferrer J, Froguel P, Rutter GRet al., 2022, Impact of type 2 diabetes-associated variants at the SLC30A8 locus on transcriptional activity and function of human b cells and super-enhancer at SLC30A8 gene locus, 58th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S141-S141, ISSN: 0012-186X

Conference paper

Dance A, Derhourhi M, Canouil M, Marre M, Charpentier G, Bonnefond A, Froguel Pet al., 2022, Role of GWAS associated purinergic receptor P2RY1 gene in insulin secretion and the impact of rare variants on type 2 diabetes risk, Publisher: SPRINGER, Pages: S155-S155, ISSN: 0012-186X

Conference paper

Orioli L, Canouil M, Sawadogo K, Ning L, Deldicque L, Lause P, de Barsy M, Froguel P, Loumaye A, Deswysen Y, Navez B, Bonnefond A, Thissen J-Pet al., 2022, Identification of myokines potentially involved in the improvement of glucose homeostasis after bariatric surgery, 58th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S239-S239, ISSN: 0012-186X

Conference paper

Kahoul Y, Montaigne J, Caron E, Bongiovanni A, Oger F, Froguel P, Bonnefond A, Annicotte J-S, Breton Cet al., 2022, The adipocyte-specific deletion of the tumor suppressor gene CDKN2a improves glucose tolerance in high-fat diet-fed mice, 58th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S271-S271, ISSN: 0012-186X

Conference paper

Saeed S, Manzoor J, Khanam R, Janjua Q, Ning L, Ayesha H, Khan W, Bonnefond A, Hanook S, Butt T, Arslan M, Froguel Pet al., 2022, Natural History of LEP, LEPR and MC4R Deficiencies - A Population-Based Study, Publisher: KARGER, Pages: 35-36, ISSN: 1663-2818

Conference paper

Zaibi NS, Montaigne J, Devos C, Baraka-Vidot J, Merrheim J, Derhourhi M, Froguel P, Bonnefond A, Chambrey Ret al., 2022, Metabolic acidosis in mice increases glucose tolerance by decreasing hepatic gluconeogenesis and proximal tubule glucose reabsorption, Publisher: WILEY, Pages: 339-339, ISSN: 1748-1708

Conference paper

Meulebrouck S, Canouil M, Derhourhi M, Balkau B, Charpentier G, Franc S, Michel M, Roussel R, Vaxillaire M, Froguel P, Bonnefond Aet al., 2022, The impact of rare pathogenic variants of GLIS3 on type 2 diabetes, 58th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S37-S37, ISSN: 0012-186X

Conference paper

Bourouh C, Courty E, Rolland L, Pasquetti G, Gromada X, Rabhi N, Carney C, Moreno M, Boutry R, Caron E, Benfodda Z, Meffre P, Kerr-Conte J, Pattou F, Froguel P, Bonnefond A, Oger F, Annicotte J-Set al., 2022, The transcription factor E2F1 controls the GLP-1 receptor pathway in pancreatic β cells, CELL REPORTS, Vol: 40, ISSN: 2211-1247

Journal article

Lemaitre M, Douillard C, Froguel P, Bonnefond A, Vambergue Aet al., 2022, Management of pregnancy in a patient with congenital hyperinsulinism treated with association of diazoxide/calcium channel blocker, ACTA DIABETOLOGICA, Vol: 59, Pages: 1117-1120, ISSN: 0940-5429

Journal article

Pelletier A, Carrier A, Zhao Y, Canouil M, Derhourhi M, Durand E, Berberian-Ferrato L, Greally J, Hughes F, Froguel P, Bonnefond A, Delahaye Fet al., 2022, Epigenetic and Transcriptomic Programming of HSC Quiescence Signaling in Large for Gestational Age Neonates, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol: 23

Journal article

Khamis A, Ning L, Balkau B, Bonnefond A, Canouil M, Roussel R, Froguel Pet al., 2022, Epigenetic changes associated with hyperglycaemia exposure in the longitudinal DESIR cohort, DIABETES & METABOLISM, Vol: 48, ISSN: 1262-3636

Journal article

Mahajan A, Spracklen CN, Zhang W, Ng MCY, Petty LE, Kitajima H, Yu GZ, Rueger S, Speidel L, Kim YJ, Horikoshi M, Mercader JM, Taliun D, Moon S, Kwak S-H, Robertson NR, Rayner NW, Loh M, Kim B-J, Chiou J, Miguel-Escalada I, Parolo PDB, Lin K, Bragg F, Preuss MH, Takeuchi F, Nano J, Guo X, Lamri A, Nakatochi M, Scott RA, Lee J-J, Huerta-Chagoya A, Graff M, Chai J-F, Parra EJ, Yao J, Bielak LF, Tabara Y, Hai Y, Steinthorsdottir V, Cook JP, Kals M, Grarup N, Schmidt EM, Pan I, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Long J, Sun M, Tong L, Chen W-M, Ahmad M, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen C-H, Raffield LM, Lecoeur C, Prins BP, Nicolas A, Yanek LR, Chen G, Jensen RA, Tajuddin S, Kabagambe EK, An P, Xiang AH, Choi HS, Cade BE, Tan J, Flanagan J, Abaitua F, Adair LS, Adeyemo A, Aguilar-Salinas CA, Akiyama M, Anand SS, Bertoni A, Bian Z, Bork-Jensen J, Brandslund I, Brody JA, Brummett CM, Buchanan TA, Canouil M, Chan JCN, Chang L-C, Chee M-L, Chen J, Chen S-H, Chen Y-T, Chen Z, Chuang L-M, Cushman M, Das SK, de Silva HJ, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Eckardt K-U, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I, Fornage M, Franco OH, Frayling TM, Freedman B, Fuchsberger C, Genter P, Gerstein HC, Giedraitis V, Gonzalez-Villalpando C, Gonzalez-Villalpando ME, Goodarzi MO, Gordon-Larsen P, Gorkin D, Gross M, Guo Y, Hackinger S, Han S, Hattersley AT, Herder C, Howard A-G, Hsueh W, Huang M, Huang W, Hung Y-J, Hwang MY, Hwu C-M, Ichihara S, Ikram MA, Ingelsson M, Islam MT, Isono M, Jang H-M, Jasmine F, Jiang G, Jonas JB, Jorgensen ME, Jorgensen T, Kamatani Y, Kandeel FR, Kasturiratne A, Katsuya T, Kaur V, Kawaguchi T, Keaton JM, Kho AN, Khor C-C, Kibriya MG, Kim D-H, Kohara K, Kriebel J, Kronenberg F, Kuusisto J, Lall K, Lange LA, Lee M-S, Lee NR, Leong A, Li L, Li Y, Li-Gao R, Ligthart S, Lindgren CM, Linneberg A, Liu C-T, Liu J, Locke AE, Louie T, Luan J, Luk AO, Luo X, Lv J, Lyssenko V, Mamakou V, Mani KR, Meitinet al., 2022, Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation, NATURE GENETICS, Vol: 54, Pages: 560-+, ISSN: 1061-4036

Journal article

Balkhiyarova Z, Demirkan A, Pupko I, Ulrich A, Zudina L, Maina J, Riboli E, Kaakinen M, Froguel P, Gunter MJ, Prokopenko Iet al., 2022, Blood metabolite levels have shared genetic effects and affect risk of breast and colorectal cancer, Publisher: KARGER, Pages: 33-33, ISSN: 0001-5652

Conference paper

Pupko I, Demirkan A, Zudina L, Balkhiyarova Z, Ulrich A, Pascat V, Maina J, Froguel P, Riboli E, Gunter M, Kaakinen M, Prokopenko Iet al., 2022, Multi-phenotype GWAS uncovers shared genetic loci between type 2 diabetes, BMI, colorectal, pancreatic, breast and prostate cancers, Publisher: KARGER, Pages: 35-35, ISSN: 0001-5652

Conference paper

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