Publications
1181 results found
Rayner W, Zeggini E, Groves CJ, et al., 2005, Positional candidate gene selection on chromosome 1q using bioinformatics and large scale association analysis, 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Publisher: SPRINGER, Pages: A108-A108, ISSN: 0012-186X
Lombardo E, Jaziri R, Bellili N, et al., 2005, Relationship between non alcoholic steatohepatitis (NASH) and insulin resistance and role of PPARγ2 and adiponectin polymorphisms in these metabolic disorders, 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Publisher: SPRINGER, Pages: A60-A60, ISSN: 0012-186X
Allotey RA, Mohan V, McDermott MF, et al., 2004, The EIF2AK3 gene region and type 1 diabetes in subjects from South India, GENES AND IMMUNITY, Vol: 5, Pages: 648-652, ISSN: 1466-4879
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- Citations: 13
Gibson F, Froguel P, 2004, Genetics of the <i>APM1</i> locus and its contribution to type 2 diabetes susceptibility in French Caucasians, DIABETES, Vol: 53, Pages: 2977-2983, ISSN: 0012-1797
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- Citations: 56
Leprêtre F, Linton KJ, Lacquemant C, et al., 2004, Genetic study of the CD36 gene In a French diabetic population, DIABETES & METABOLISM, Vol: 30, Pages: 459-463, ISSN: 1262-3636
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- Citations: 37
Yamauchi T, Kamon J, Ito Y, et al., 2004, Cloning of adiponectin receptors that mediate antidiabetic metabolic effects (vol 423, pg 762, 2003), NATURE, Vol: 431, Pages: 1123-1123, ISSN: 0028-0836
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- Citations: 17
Vaxillaire M, Populaire C, Busiah K, et al., 2004, Kir6.2 mutations are a common cause of permanent neonatal diabetes in a large cohort of French patients, DIABETES, Vol: 53, Pages: 2719-2722, ISSN: 0012-1797
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- Citations: 143
Dina C, Boutin P, Froguel P, 2004, Genetic association analyses of GAD2 (GABA pathway) with food behaviour scores and latent obesity, 12th World Congress of Psychiatric Genetics, Publisher: WILEY-LISS, Pages: 119-119, ISSN: 0148-7299
Durand E, Boutin P, Meyre D, et al., 2004, Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians, DIABETES, Vol: 53, Pages: 2483-2486, ISSN: 0012-1797
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- Citations: 65
Vaxillaire M, Cheyssac C, Dina C, et al., 2004, EIF4α2 on chromosome 3q27 is a positional candidate gene for Type 2 diabetes, 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Publisher: SPRINGER, Pages: A81-A81, ISSN: 0012-186X
Eberlé D, Clément K, Meyre D, et al., 2004, SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts, DIABETES, Vol: 53, Pages: 2153-2157, ISSN: 0012-1797
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- Citations: 95
, 2004, 40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004., Diabetologia, Vol: 47, Pages: A1-A464
Neve B, Fernandez-Zapico ME, Ashkenazi-Katalan V, et al., 2004, Altered functional variants of TGFβ-inducible transcription factor KLF11 are associated with diabetes, 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Publisher: SPRINGER, Pages: A81-A81, ISSN: 0012-186X
Tsuchida A, Yamauchi T, Ito Y, et al., 2004, Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 279, Pages: 30817-30822, ISSN: 0021-9258
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- Citations: 437
Bell CG, Benzinou M, Siddiq A, et al., 2004, Genome-wide linkage analysis for severe obesity in French Caucasians finds significant susceptibility locus on chromosome 19q, DIABETES, Vol: 53, Pages: 1857-1865, ISSN: 0012-1797
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- Citations: 56
Leprêtre F, Vasseur F, Vaxillaire M, et al., 2004, A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes., Hum Mutat, Vol: 24
Mutations in CD36 / fatty acid translocase (FAT) gene are responsible for insulin resistance in the rat but contribution to human Type 2 diabetes is unknown. A nominal evidence for linkage of familial T2D at the CD36 locus led us to identify a rare nonsense mutation c.1079T>G (p.L360X) in one Caucasian pedigree presenting with autosomal dominant diabetes. Adiponectin levels, as marker of insulin sensitivity, were found to be significantly lower in the p.L360X variant carriers compared to homozygous for wild type CD36. Furthermore, expression studies of the truncated protein showed a defective binding of acetylated-LDL. Thus, our findings suggest a possible role for CD36 in the pathogenesis of T2D associated with reduced insulin sensitivity.
Kipfer-Coudreau S, Eberlé D, Sahbatou M, et al., 2004, Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects, DIABETOLOGIA, Vol: 47, Pages: 1278-1284, ISSN: 0012-186X
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- Citations: 28
Lacquemant C, Froguel P, Lobbens S, et al., 2004, The adiponectin gene SNP+45 is associated with coronary artery disease in Type 2 (non-insulin-dependent) diabetes mellitus, DIABETIC MEDICINE, Vol: 21, Pages: 776-781, ISSN: 0742-3071
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- Citations: 81
Meyre D, Boutin P, Froguel P, 2004, Obesity: Genetics, behavior or a combination of both, Current Medicinal Chemistry: Immunology, Endocrine and Metabolic Agents, Vol: 4, Pages: 105-111, ISSN: 1568-0134
During the past two decades, the prevalence of obesity has greatly risen worldwide. These changes have occurred among genetically stable populations, indicating that modifications of behavioral factors like dietary and physical activity must underlie the recent obesity epidemic. However, genetic factors undoubtedly have a great effect on individual predisposition, since 25 to 80 percent of the variation in body-mass index is heritable. Eating behavior, disordered eating behaviors and food preferences are in part heritable, and a family history of overeating is more frequent in obese individuals with binge-eating disorder than in the general population. The identification of genes causing both syndromic (Prader Willi) and rare monogenic (leptin/melanocortin pathways) forms of obesity, highlight the importance of genetic determinants in obesity. The common forms of obesity are, however, polygenic, and could modestly modulate behavior component. The recent identification of GAD2 gene variations modulating food intake and increasing the risk for severe obesity highlights the role of the GABA pathway in eating behavior. Other pathways involved in behavior, including Dopamine, serotonin and cannabinoid pathways are candidate for obese susceptibility genes. Modest individual effects of already identified at risk variants for abnormal food intake, may be amplified by gene-gene and gene-environment interactions. © 2004 Bentham Science Publishers Ltd.
Weill J, Vanderbecken S, Froguel P, 2004, Understanding the rising incidence of type 2 diabetes in adolescence, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 89, Pages: 502-504, ISSN: 0003-9888
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- Citations: 7
Fumeron F, Aubert R, Siddiq A, et al., 2004, Adiponectin gene polymorphisms and adiponectin levels are indedendently associated with the development of hyperglycemia during a 3-year period -: The Epidemiologic Data on the Insulin Resistance Syndrome prospective study, DIABETES, Vol: 53, Pages: 1150-1157, ISSN: 0012-1797
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- Citations: 166
Leprêtre F, Cheyssac C, Amouyel P, et al., 2004, A promoter polymorphism in CD36 is associated with an atherogenic lipid profile in a French general population, ATHEROSCLEROSIS, Vol: 173, Pages: 375-377, ISSN: 0021-9150
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- Citations: 14
Heude B, Dubois S, Charles MA, et al., 2004, VNTR polymorphism of the insulin gene and childhood overweight in a general population, OBESITY RESEARCH, Vol: 12, Pages: 499-504, ISSN: 1071-7323
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- Citations: 17
Meyre D, Lecoeur C, Delplanque J, et al., 2004, A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2, DIABETES, Vol: 53, Pages: 803-811, ISSN: 0012-1797
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- Citations: 119
Boutin P, Dina C, Vasseur F, et al., 2003, GAD2 on chromosome 10p12 is a candidate gene for human obesity, PLOS BIOLOGY, Vol: 1, Pages: 361-371, ISSN: 1544-9173
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- Citations: 122
Yamauchi T, Hara K, Kubota N, et al., 2003, Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine., Curr Drug Targets Immune Endocr Metabol Disord, Vol: 3, Pages: 243-254, ISSN: 1568-0088
Genome-wide scanning is a powerful tool to identify susceptible chromosome loci, however, individual chromosomal regions still have many candidate genes. Although cDNA microarray analysis provides valuable information for identifying genes involved in pathogenesis, expression levels of many genes are changed. A novel approach for identification of therapeutic targets is the combination of genome-wide scanning and the use of DNA chips, as shown in Fig. (1). Using DNA chips, we screened for secreted molecules, the expressions of which were changed in adipose tissues from mice rendered insulin resistance. Decreased expression of one of these molecules, adiponectin/Acrp30, correlates strongly with insulin resistance. Interestingly, recent genome-wide scans have mapped a susceptibility locus for type 2 diabetes and metabolic syndrome to chromosome 3q27, where adiponectin gene is located. Decreasing serum adiponectin levels are associated with increased risk for type 2 diabetes. Interestingly, adiponectin was decreased in insulin resistant rodent models both of obesity and lipoatrophy, and replenishment of adiponectin ameliorated their insulin resistance. Moreover, adiponectin transgenic mice ameliorated insulin resistance and diabetes Adiponectin knockout mice showed insulin resistance and glucose intolerance. In muscle and liver, adiponectin activated AMP kinase and PPARalpha pathways thereby increasing beta-oxidation of lipids, leading to decreased TG content, which ameliorated insulin resistance under a high-fat diet. Despite similar plasma glucose and lipid levels on an apoE deficient background, adiponectin transgenic apoE deficient mice showed amelioration of atherosclerosis, which was associated with decreased expressions of class A scavenger receptor and tumor necrosis factor alpha. Finally, cDNA encoding adiponectin receptors (AdipoR1 and R2) have been identified by expression cloning, which facilitates the understanding of molecular mechanisms of adiponectin ac
Yamauchi T, Kamon J, Terauchi Y, et al., 2003, Cloning of receptors for adiponectin that mediates anti-diabetic and anti-atherogenic effeccts, 76th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 113-113, ISSN: 0009-7322
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- Citations: 1
Waki H, Yamauchi T, Kamon J, et al., 2003, Impaired multimerization of human adiponectin mutants associated with diabetes - Molecular structure and multimer formation of adiponectin, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 278, Pages: 40352-40363, ISSN: 0021-9258
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- Citations: 804
Coudreau SK, Tounian P, Bonhomme G, et al., 2003, Role of the <i>DGAT</i> gene C79T single-nucleotide polymorphism in french obese subjects, OBESITY RESEARCH, Vol: 11, Pages: 1163-1167, ISSN: 1071-7323
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- Citations: 12
Lopes C, Dina C, Durand E, et al., 2003, PAI-1 polymorphisms modulate phenotypes associated with the metabolic syndrome in obese and diabetic Caucasian population, DIABETOLOGIA, Vol: 46, Pages: 1284-1290, ISSN: 0012-186X
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- Citations: 48
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