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@article{Koivula:2019:10.1007/s00125-019-4906-1,
author = {Koivula, RW and Forgie, IM and Kurbasic, A and Viñuela, A and Heggie, A and Giordano, GN and Hansen, TH and Hudson, M and Koopman, ADM and Rutters, F and Siloaho, M and Allin, KH and Brage, S and Brorsson, CA and Dawed, AY and De, Masi F and Groves, CJ and Kokkola, T and Mahajan, A and Perry, MH and Rauh, SP and Ridderstråle, M and Teare, HJA and Thomas, EL and Tura, A and Vestergaard, H and White, T and Adamski, J and Bell, JD and Beulens, JW and Brunak, S and Dermitzakis, ET and Froguel, P and Frost, G and Gupta, R and Hansen, T and Hattersley, A and Jablonka, B and Kaye, J and Laakso, M and McDonald, TJ and Pedersen, O and Schwenk, JM and Pavo, I and Mari, A and McCarthy, MI and Ruetten, H and Walker, M and Pearson, E and Franks, PW and IMI, DIRECT Consortium},
doi = {10.1007/s00125-019-4906-1},
journal = {Diabetologia},
pages = {1601--1615},
title = {Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium.},
url = {http://dx.doi.org/10.1007/s00125-019-4906-1},
volume = {62},
year = {2019}
}

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TY  - JOUR
AB  - AIMS/HYPOTHESIS: Here, we describe the characteristics of the Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) epidemiological cohorts at baseline and follow-up examinations (18, 36 and 48 months of follow-up). METHODS: From a sampling frame of 24,682 adults of European ancestry enrolled in population-based cohorts across Europe, participants at varying risk of glycaemic deterioration were identified using a risk prediction algorithm (based on age, BMI, waist circumference, use of antihypertensive medication, smoking status and parental history of type 2 diabetes) and enrolled into a prospective cohort study (n = 2127) (cohort 1, prediabetes risk). We also recruited people from clinical registries with type 2 diabetes diagnosed 6-24 months previously (n = 789) into a second cohort study (cohort 2, diabetes). Follow-up examinations took place at ~18 months (both cohorts) and at ~48 months (cohort 1) or ~36 months (cohort 2) after baseline examinations. The cohorts were studied in parallel using matched protocols across seven clinical centres in northern Europe. RESULTS: Using ADA 2011 glycaemic categories, 33% (n = 693) of cohort 1 (prediabetes risk) had normal glucose regulation and 67% (n = 1419) had impaired glucose regulation. Seventy-six per cent of participants in cohort 1 was male. Cohort 1 participants had the following characteristics (mean ± SD) at baseline: age 62 (6.2) years; BMI 27.9 (4.0) kg/m2; fasting glucose 5.7 (0.6) mmol/l; 2 h glucose 5.9 (1.6) mmol/l. At the final follow-up examination the participants' clinical characteristics were as follows: fasting glucose 6.0 (0.6) mmol/l; 2 h OGTT glucose 6.5 (2.0) mmol/l. In cohort 2 (diabetes), 66% (n = 517) were treated by lifestyle modification and 34% (n = 272) were treated with metformin plus lifestyle modification at enro
AU  - Koivula,RW
AU  - Forgie,IM
AU  - Kurbasic,A
AU  - Viñuela,A
AU  - Heggie,A
AU  - Giordano,GN
AU  - Hansen,TH
AU  - Hudson,M
AU  - Koopman,ADM
AU  - Rutters,F
AU  - Siloaho,M
AU  - Allin,KH
AU  - Brage,S
AU  - Brorsson,CA
AU  - Dawed,AY
AU  - De,Masi F
AU  - Groves,CJ
AU  - Kokkola,T
AU  - Mahajan,A
AU  - Perry,MH
AU  - Rauh,SP
AU  - Ridderstråle,M
AU  - Teare,HJA
AU  - Thomas,EL
AU  - Tura,A
AU  - Vestergaard,H
AU  - White,T
AU  - Adamski,J
AU  - Bell,JD
AU  - Beulens,JW
AU  - Brunak,S
AU  - Dermitzakis,ET
AU  - Froguel,P
AU  - Frost,G
AU  - Gupta,R
AU  - Hansen,T
AU  - Hattersley,A
AU  - Jablonka,B
AU  - Kaye,J
AU  - Laakso,M
AU  - McDonald,TJ
AU  - Pedersen,O
AU  - Schwenk,JM
AU  - Pavo,I
AU  - Mari,A
AU  - McCarthy,MI
AU  - Ruetten,H
AU  - Walker,M
AU  - Pearson,E
AU  - Franks,PW
AU  - IMI,DIRECT Consortium
DO  - 10.1007/s00125-019-4906-1
EP  - 1615
PY  - 2019///
SN  - 0012-186X
SP  - 1601
TI  - Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium.
T2  - Diabetologia
UR  - http://dx.doi.org/10.1007/s00125-019-4906-1
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31203377
UR  - https://link.springer.com/article/10.1007%2Fs00125-019-4906-1
UR  - http://hdl.handle.net/10044/1/71790
VL  - 62
ER  -

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