I describe myself as a biological chemist. This means I use organic synthetic chemistry to help solve biological problems. Because biological scientists use a wide range of primary metabolites in their work, I have focussed on their synthesis. My targets have included peptides, ribonucleic acids and oligosaccharides, although my greatest experience is in the area of phospholipids, especially phosphoinositides. However, supplying synthetic natural products does not necessarily provide the key to solving many biological problems. So we also make analogues of natural products incorporating features that help biological scientists analyse behaviour in vivo, such as fluorescent or affinity probes, and protein cross-linking reactive groups. Chemically related to this core interest, I have also developed multi-functional labels for proteomics and lipidomics.
Recently I have joined the group of Prof. Andrew Livingston in the Chemical Engineering Department where I have been applying organic solvent nanofiltration (OSN) to the large scale synthesis of oligoribonucleotides and mono-disperse poly-ethylene glycols.
et al., 2022, <p>(???????)Graft modification of polybenzimidazole membranes for organic solvent ultrafiltration with scale up to spiral wound modules</p>, Journal of Membrane Science, Vol:647, ISSN:0376-7388
et al., 2021, Liquid phase peptide synthesis via one‐pot nanostar sieving (PEPSTAR), Angewandte Chemie International Edition, Vol:60, ISSN:1433-7851, Pages:7786-7795
et al., 2019, Sequence-defined multifunctional polyethers via liquid-phase synthesis with molecular sieving, Nature Chemistry, Vol:11, ISSN:1755-4330, Pages:136-145
et al., 2019, Author Correction: Sequence-defined multifunctional polyethers via liquid-phase synthesis with molecular sieving, Nature Chemistry, Vol:11, ISSN:1755-4330, Pages:184-184
et al., 2019, The pH-dependence of lipid-mediated antimicrobial peptide resistance in a model staphylococcal plasma membrane: A two-for-one mechanism of epithelial defence circumvention., Eur J Pharm Sci, Vol:128, Pages:43-53