Imperial College London
Dr Peter Gatehouse

DrPeterGatehouse

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7351 8807p.gatehouse

 
 
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Location

 

MRISydney StreetRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gorodezky:2019,
author = {Gorodezky, M and Ferreira, P and Nielles-Vallespin, S and Gatehouse, P and Pennell, D and Scott, A and Firmin, D},
journal = {Magnetic Resonance in Medicine},
pages = {1580--1594},
title = {High resolution in-vivo DT-CMR using an interleaved variable density spiral STEAM sequence},
url = {https://onlinelibrary.wiley.com/doi/full/10.1002/mrm.27504},
volume = {81},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Purpose: Diffusion tensor cardiovascular magnetic resonance (DT-CMR) has a limited spatial resolution. Thepurpose of this study was to demonstrate high-resolution DT-CMR using a segmented variable density spiralsequence with correction for motion, off-resonance and T2 related blurring.Methods: A single-shot STEAM EPI DT-CMR sequence at 2.8x2.8x8mm3 and 1.8x1.8x8mm3 was compared to asingle shot spiral at 2.8x2.8x8mm3 and an interleaved spiral sequence at 1.8x1.8x8mm3resolution in 10 healthyvolunteers at peak-systole and diastasis. Motion-induced phase was corrected using the densely sampledcentral k-space data of the spirals. STEAM field maps and T2 measures were obtained using a pair ofstimulated echoes each with a double spiral readout, the first used to correct the motion-induced phase of thesecond.Results: The high resolution spiral sequence produced similar DT-CMR results and quality measures to thestandard resolution sequence in both cardiac phases. Residual differences in fractional anisotropy and helixangle gradient between the resolutions could be due to spatial resolution and/or signal to noise ratio. The dataquality increased after both motion-induced phase correction and off-resonance correction and sharpnessincreased after T2 correction. The high resolution EPI sequence failed to provide sufficient data quality forDT-CMR reconstruction.Conclusion: In this study an in-vivo DT-CMR acquisition at 1.8x1.8mm2in-plane resolution was demonstratedusing a segmented spiral STEAM sequence. The motion-induced phase and off-resonance corrections areessential for high resolution spiral DT-CMR. Segmented variable density spiral STEAM was found to be theoptimal method for acquiring high resolution DT-CMR data.
AU  - Gorodezky,M
AU  - Ferreira,P
AU  - Nielles-Vallespin,S
AU  - Gatehouse,P
AU  - Pennell,D
AU  - Scott,A
AU  - Firmin,D
EP  - 1594
PY  - 2019///
SN  - 0740-3194
SP  - 1580
TI  - High resolution in-vivo DT-CMR using an interleaved variable density spiral STEAM sequence
T2  - Magnetic Resonance in Medicine
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/mrm.27504
UR  - http://hdl.handle.net/10044/1/63277
VL  - 81
ER  -
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