Imperial College London
Dr Peter Gatehouse

DrPeterGatehouse

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7351 8807p.gatehouse

 
 
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Location

 

MRISydney StreetRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Allen:2023:10.1016/j.mri.2022.12.014,
author = {Allen, JJ and Keegan, J and Mathew, G and Conway, M and Jenkins, S and Pennell, DJ and Nielles-Vallespin, S and Gatehouse, P and Babu-Narayan, SV},
doi = {10.1016/j.mri.2022.12.014},
journal = {Magnetic Resonance Imaging},
pages = {44--54},
title = {Fully-modelled blood-focused variable inversion times for 3D late gadolinium-enhanced imaging},
url = {http://dx.doi.org/10.1016/j.mri.2022.12.014},
volume = {98},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PurposeVariable heart rate during single-cycle inversion-recovery Late Gadolinium-Enhanced (LGE) scanning degrades image quality, which can be mitigated using Variable Inversion Times (VTIs) in real-time response to R-R interval changes. We investigate in vivo and in simulations an extension of a single-cycle VTI method previously applied in 3D LGE imaging, that now fully models the longitudinal magnetisation (fmVTI).MethodsThe VTI and fmVTI methods were used to perform 3D LGE scans for 28 3D LGE patients, with qualitative image quality scores assigned for left atrial wall clarity and total ghosting. Accompanying simulations of numerical phantom images were assessed in terms of ghosting of normal myocardium, blood, and myocardial scar.ResultsThe numerical simulations for fmVTI showed a significant decrease in blood ghosting (VTI: 410 ± 710, fmVTI: 68 ± 40, p < 0.0005) and scar ghosting (VTI: 830 ± 1300, fmVTI: 510 ± 730, p < 0.02). Despite this, there was no significant change in qualitative image quality scores, either for left atrial wall clarity (VTI: 2.0 ± 1.0, fmVTI: 1.8 ± 1.0, p > 0.1) or for total ghosting (VTI: 1.9 ± 1.0, fmVTI: 2.0 ± 1.0, p > 0.7).ConclusionsSimulations indicated reduced ghosting with the fmVTI method, due to reduced Mz variability in the blood signal. However, other sources of phase-encode ghosting and blurring appeared to dominate and obscure this finding in the patient studies available.
AU  - Allen,JJ
AU  - Keegan,J
AU  - Mathew,G
AU  - Conway,M
AU  - Jenkins,S
AU  - Pennell,DJ
AU  - Nielles-Vallespin,S
AU  - Gatehouse,P
AU  - Babu-Narayan,SV
DO  - 10.1016/j.mri.2022.12.014
EP  - 54
PY  - 2023///
SN  - 0730-725X
SP  - 44
TI  - Fully-modelled blood-focused variable inversion times for 3D late gadolinium-enhanced imaging
T2  - Magnetic Resonance Imaging
UR  - http://dx.doi.org/10.1016/j.mri.2022.12.014
UR  - https://www.sciencedirect.com/science/article/pii/S0730725X22002296?via%3Dihub
UR  - http://hdl.handle.net/10044/1/102637
VL  - 98
ER  -
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