Imperial College London
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Dr Peter M George

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

p.george

 
 
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Location

 

Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Stock:2020:10.1136/thoraxjnl-2020-214579,
author = {Stock, CJ and Conti, C and Montero-Fernandez, Á and Caramori, G and Molyneaux, PL and George, PM and Kokosi, M and Kouranos, V and Maher, TM and Chua, F and Rice, A and Denton, CP and Nicholson, AG and Wells, A and Sestini, P and Renzoni, EA},
doi = {10.1136/thoraxjnl-2020-214579},
journal = {Thorax},
pages = {901--903},
title = {Interaction between the promoter MUC5B polymorphism and mucin expression: is there a difference according to ILD subtype?},
url = {http://dx.doi.org/10.1136/thoraxjnl-2020-214579},
volume = {75},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The MUC5B promoter variant rs35705950 is associated with idiopathic pulmonary fibrosis (IPF). MUC5B glycoprotein is overexpressed in IPF lungs. We examined immunohistochemical expression of MUC5B in different interstitial lung disease patterns according to rs35705950 T-allele carriage. We observed increased expression of MUC5B in T-allele carriers in both distal airways and honeycomb cysts in patients with IPF (n=23), but no difference in MUC5B expression according to T-carrier status in the distal airways of patients with idiopathic non-specific interstitial pneumonitis (n=17), in scleroderma-associated non-specific interstitial pneumonitis (n=15) or in control lungs (n=20), suggesting that tissue overexpression in MUC5B rs35705950 T-carriers is specific to IPF.
AU  - Stock,CJ
AU  - Conti,C
AU  - Montero-Fernandez,Á
AU  - Caramori,G
AU  - Molyneaux,PL
AU  - George,PM
AU  - Kokosi,M
AU  - Kouranos,V
AU  - Maher,TM
AU  - Chua,F
AU  - Rice,A
AU  - Denton,CP
AU  - Nicholson,AG
AU  - Wells,A
AU  - Sestini,P
AU  - Renzoni,EA
DO  - 10.1136/thoraxjnl-2020-214579
EP  - 903
PY  - 2020///
SN  - 0040-6376
SP  - 901
TI  - Interaction between the promoter MUC5B polymorphism and mucin expression: is there a difference according to ILD subtype?
T2  - Thorax
UR  - http://dx.doi.org/10.1136/thoraxjnl-2020-214579
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32580994
UR  - http://hdl.handle.net/10044/1/81835
VL  - 75
ER  -
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