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@unpublished{Drake:2020:10.1101/2020.07.15.20152967,
author = {Drake, TM and Docherty, AB and Harrison, EM and Quint, JK and Adamali, H and Agnew, S and Babu, S and Barber, CM and Barratt, S and Bendstrup, E and Bianchi, S and Villegas, DC and Chaudhuri, N and Chua, F and Coker, R and Chang, W and Crawshaw, A and Crowley, LE and Dosanjh, D and Fiddler, CA and Forrest, IA and George, P and Gibbons, MA and Groom, K and Haney, S and Hart, SP and Heiden, E and Henry, M and Ho, L-P and Hoyles, RK and Hutchinson, J and Hurley, K and Jones, M and Jones, S and Kokosi, M and Kreuter, M and MacKay, L and Mahendran, S and Margaritopoulos, G and Molina-Molina, M and Molyneaux, PL and OBrien, A and OReilly, K and Packham, A and Parfrey, H and Poletti, V and Porter, J and Renzoni, E and Rivera-Ortega, P and Russell, A-M and Saini, G and Spencer, LG and Stella, GM and Stone, H and Sturney, S and Thickett, D and Thillai, M and Wallis, T and Ward, K and Wells, AU and West, A and Wickremasinghe, M and Woodhead, F and Hearson, G and Howard, L and Baillie, JK and Ope},
doi = {10.1101/2020.07.15.20152967},
publisher = {bioRxiv},
title = {Outcome of hospitalisation for COVID-19 in patients with interstitial lung disease: an international multicentre study.},
url = {http://dx.doi.org/10.1101/2020.07.15.20152967},
year = {2020}
}

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TY  - UNPB
AB  - Rationale: The impact of COVID-19 on patients with Interstitial Lung Disease (ILD) has not been established. Objectives: To assess outcomes following COVID-19 in patients with ILD versus those without in a contemporaneous age, sex and comorbidity matched population. Methods: An international multicentre audit of patients with a prior diagnosis of ILD admitted to hospital with COVID-19 between 1 March and 1 May 2020 was undertaken and compared with patients, without ILD obtained from the ISARIC 4C cohort, admitted with COVID-19 over the same period. The primary outcome was survival. Secondary analysis distinguished IPF from non-IPF ILD and used lung function to determine the greatest risks of death. Measurements and Main Results: Data from 349 patients with ILD across Europe were included, of whom 161 were admitted to hospital with laboratory or clinical evidence of COVID-19 and eligible for propensity-score matching. Overall mortality was 49% (79/161) in patients with ILD with COVID-19. After matching ILD patients with COVID-19 had higher mortality (HR 1.60, Confidence Intervals 1.17-2.18 p=0.003) compared with age, sex and co-morbidity matched controls without ILD. Patients with a Forced Vital Capacity (FVC) of <80% had an increased risk of death versus patients with FVC ≥80% (HR 1.72, 1.05-2.83). Furthermore, obese patients with ILD had an elevated risk of death (HR 1.98, 1.13−3.46). Conclusions: Patients with ILD are at increased risk of death from COVID-19, particularly those with poor lung function and obesity. Stringent precautions should be taken to avoid COVID-19 in patients with ILD.
AU  - Drake,TM
AU  - Docherty,AB
AU  - Harrison,EM
AU  - Quint,JK
AU  - Adamali,H
AU  - Agnew,S
AU  - Babu,S
AU  - Barber,CM
AU  - Barratt,S
AU  - Bendstrup,E
AU  - Bianchi,S
AU  - Villegas,DC
AU  - Chaudhuri,N
AU  - Chua,F
AU  - Coker,R
AU  - Chang,W
AU  - Crawshaw,A
AU  - Crowley,LE
AU  - Dosanjh,D
AU  - Fiddler,CA
AU  - Forrest,IA
AU  - George,P
AU  - Gibbons,MA
AU  - Groom,K
AU  - Haney,S
AU  - Hart,SP
AU  - Heiden,E
AU  - Henry,M
AU  - Ho,L-P
AU  - Hoyles,RK
AU  - Hutchinson,J
AU  - Hurley,K
AU  - Jones,M
AU  - Jones,S
AU  - Kokosi,M
AU  - Kreuter,M
AU  - MacKay,L
AU  - Mahendran,S
AU  - Margaritopoulos,G
AU  - Molina-Molina,M
AU  - Molyneaux,PL
AU  - OBrien,A
AU  - OReilly,K
AU  - Packham,A
AU  - Parfrey,H
AU  - Poletti,V
AU  - Porter,J
AU  - Renzoni,E
AU  - Rivera-Ortega,P
AU  - Russell,A-M
AU  - Saini,G
AU  - Spencer,LG
AU  - Stella,GM
AU  - Stone,H
AU  - Sturney,S
AU  - Thickett,D
AU  - Thillai,M
AU  - Wallis,T
AU  - Ward,K
AU  - Wells,AU
AU  - West,A
AU  - Wickremasinghe,M
AU  - Woodhead,F
AU  - Hearson,G
AU  - Howard,L
AU  - Baillie,JK
AU  - Openshaw,PJM
AU  - Semple,MG
AU  - Stewart,I
AU  - ISARIC4C,Investigators
AU  - Jenkins,RG
DO  - 10.1101/2020.07.15.20152967
PB  - bioRxiv
PY  - 2020///
TI  - Outcome of hospitalisation for COVID-19 in patients with interstitial lung disease: an international multicentre study.
UR  - http://dx.doi.org/10.1101/2020.07.15.20152967
UR  - https://www.medrxiv.org/content/10.1101/2020.07.15.20152967v1
UR  - http://hdl.handle.net/10044/1/81952
ER  -

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