Imperial College London
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Dr Peter M George

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

p.george

 
 
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Location

 

Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nolan:2021:10.1136/bmjopen-2021-048808,
author = {Nolan, CM and Patel, S and Barker, RE and Walsh, JA and Polgar, O and Maddocks, M and George, PM and Renzoni, EA and Wells, AU and Molyneaux, PL and Kouranos, V and Chua, F and Maher, TM and Man, WD-C},
doi = {10.1136/bmjopen-2021-048808},
journal = {BMJ Open},
pages = {1--11},
title = {Muscle stimulation in advanced idiopathic pulmonary fibrosis: a randomised placebo-controlled feasibility study.},
url = {http://dx.doi.org/10.1136/bmjopen-2021-048808},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVES: To assess the acceptability of neuromuscular electrical stimulation (NMES) of the quadriceps muscles in people with idiopathic pulmonary fibrosis (IPF) and to identify whether a future definitive trial is feasible. DESIGN: A randomised, parallel, two-group, participant and assessor-blinded, placebo-controlled feasibility trial with embedded qualitative interviews. SETTING: Outpatient department, Royal Brompton and Harefield Hospitals. PARTICIPANTS: Twenty-two people with IPF: median (25th, 75th centiles) age 76 (74, 82) years, forced vital capacity 62 (50, 75) % predicted, 6 min walk test distance 289 (149, 360) m. INTERVENTIONS: Usual care (home-based exercise, weekly telephone support, breathlessness management leaflet) with either placebo or active NMES for 6 weeks, with follow-up at 6 and 12 weeks. PRIMARY OUTCOME MEASURES: Feasibility of recruitment and retention, treatment uptake and adherence, outcome assessments, participant and outcome assessor blinding and adverse events related to interventions. SECONDARY OUTCOME MEASURES: Outcome measures with potential to be primary or secondary outcomes in a definitive clinical trial. In addition, purposively sampled participants were interviewed to capture their experiences and acceptability of the trial. RESULTS: Out of 364 people screened, 23 were recruited: 11 were allocated to each group and one was withdrawn prior to randomisation. Compared with the control group, a greater proportion of the intervention group completed the intervention, remained in the trial blinded to group allocation and experienced intervention-related adverse events. Assessor blinding was maintained. The secondary outcome measures were feasible with most missing data associated with the accelerometer. Small participant numbers precluded identification of an outcome measure suitable for a definitive trial. Qualitative findings demonstrated that trial process and active NMES were acceptable but there were concerns abo
AU  - Nolan,CM
AU  - Patel,S
AU  - Barker,RE
AU  - Walsh,JA
AU  - Polgar,O
AU  - Maddocks,M
AU  - George,PM
AU  - Renzoni,EA
AU  - Wells,AU
AU  - Molyneaux,PL
AU  - Kouranos,V
AU  - Chua,F
AU  - Maher,TM
AU  - Man,WD-C
DO  - 10.1136/bmjopen-2021-048808
EP  - 11
PY  - 2021///
SN  - 2044-6055
SP  - 1
TI  - Muscle stimulation in advanced idiopathic pulmonary fibrosis: a randomised placebo-controlled feasibility study.
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2021-048808
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34083348
UR  - https://bmjopen.bmj.com/content/11/6/e048808
UR  - http://hdl.handle.net/10044/1/90345
VL  - 11
ER  -
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