Imperial College London
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DrPennyHancock

Faculty of Medicine, School of Public Health

Lecturer in Biostatistics / Epidemiology (Non Clinical)
 
 
 
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p.hancock

 
 
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Location

 

St Marys Multiple BuildingsSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hancock:2019:10.1111/1365-2664.13423,
author = {Hancock, PA and Ritchie, SA and Koenraadt, CJM and Scott, TW and Hoffmann, AA and Godfray, HCJ},
doi = {10.1111/1365-2664.13423},
journal = {Journal of Applied Ecology},
pages = {1674--1686},
title = {Predicting the spatial dynamics of <i>Wolbachia</i> infections in <i>Aedes aegypti</i> arbovirus vector populations in heterogeneous landscapes},
url = {http://dx.doi.org/10.1111/1365-2664.13423},
volume = {56},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p><jats:list><jats:list-item><jats:p>A promising strategy for reducing the transmission of dengue and other arboviral human diseases by <jats:italic>Aedes aegypti</jats:italic> mosquito vector populations involves field introductions of the endosymbiotic bacteria <jats:italic>Wolbachia</jats:italic>. <jats:italic>Wolbachia</jats:italic> infections inhibit viral transmission by the mosquito, and can spread between mosquito hosts to reach high frequencies in the vector population. <jats:italic>Wolbachia</jats:italic> spreads by maternal transmission, and spread dynamics can be variable and highly dependent on natural mosquito population dynamics, population structure and fitness components.</jats:p></jats:list-item><jats:list-item><jats:p>We develop a mathematical model of an <jats:italic>A. aegypti</jats:italic> metapopulation that incorporates empirically validated relationships describing densitydependent mosquito fitness components. We assume that density dependent relationships differ across subpopulations, and construct heterogeneous landscapes for which modelpredicted patterns of variation in mosquito abundance and demography approximate those observed in field populations. We then simulate <jats:italic>Wolbachia</jats:italic> release strategies similar to that used in field trials.</jats:p></jats:list-item><jats:list-item><jats:p>We show that our model can produce rates of spatial spread of <jats:italic>Wolbachia</jats:italic> similar to those observed following field releases.</jats:p></jats:list-item><jats:list-item><jats:p>We then investigate how different types of spatiotemporal variation in mosquito habitat, as well as different fitness costs incurred by <jats:italic>Wolbachia</jats:italic> on the mosquito host, i
AU  - Hancock,PA
AU  - Ritchie,SA
AU  - Koenraadt,CJM
AU  - Scott,TW
AU  - Hoffmann,AA
AU  - Godfray,HCJ
DO  - 10.1111/1365-2664.13423
EP  - 1686
PY  - 2019///
SN  - 0021-8901
SP  - 1674
TI  - Predicting the spatial dynamics of <i>Wolbachia</i> infections in <i>Aedes aegypti</i> arbovirus vector populations in heterogeneous landscapes
T2  - Journal of Applied Ecology
UR  - http://dx.doi.org/10.1111/1365-2664.13423
VL  - 56
ER  -
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