Imperial College London
Alternate

Professor Sir Peter Barnes, FRS, FMedSci

Faculty of Medicine, National Heart & Lung Institute

Senior Research Investigator
 
 
 
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Contact

 

+44 (0)20 7594 7959p.j.barnes Website CV

 
 
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Assistant

 

Miss Carolyn Green +44 (0)20 7594 7959

 
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Location

 

227CGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Koss:2021:10.1038/s42003-021-01703-3,
author = {Koss, CK and Wohnhaas, CT and Baker, JR and Tilp, C and Przibilla, M and Lerner, C and Frey, S and Keck, M and Williams, CMM and Peter, D and Ramanujam, M and Fine, J and Gantner, F and Thomas, M and Barnes, PJ and Donnelly, LE and El, Kasmi KC},
doi = {10.1038/s42003-021-01703-3},
journal = {Communications Biology},
pages = {1--15},
title = {IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice},
url = {http://dx.doi.org/10.1038/s42003-021-01703-3},
volume = {4},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - IL-36, which belongs to the IL-1 superfamily, is increasingly linked to neutrophilic inflammation. Here, we combined in vivo and in vitro approaches using primary mouse and human cells, as well as, acute and chronic mouse models of lung inflammation to provide mechanistic insight into the intercellular signaling pathways and mechanisms through which IL-36 promotes lung inflammation. IL-36 receptor deficient mice exposed to cigarette smoke or cigarette smoke and H1N1 influenza virus had attenuated lung inflammation compared with wild-type controls. We identified neutrophils as a source of IL-36 and show that IL-36 is a key upstream amplifier of lung inflammation by promoting activation of neutrophils, macrophages and fibroblasts through cooperation with GM-CSF and the viral mimic poly(I:C). Our data implicate IL-36, independent of other IL-1 family members, as a key upstream amplifier of neutrophilic lung inflammation, providing a rationale for targeting IL-36 to improve treatment of a variety of neutrophilic lung diseases.
AU  - Koss,CK
AU  - Wohnhaas,CT
AU  - Baker,JR
AU  - Tilp,C
AU  - Przibilla,M
AU  - Lerner,C
AU  - Frey,S
AU  - Keck,M
AU  - Williams,CMM
AU  - Peter,D
AU  - Ramanujam,M
AU  - Fine,J
AU  - Gantner,F
AU  - Thomas,M
AU  - Barnes,PJ
AU  - Donnelly,LE
AU  - El,Kasmi KC
DO  - 10.1038/s42003-021-01703-3
EP  - 15
PY  - 2021///
SN  - 2399-3642
SP  - 1
TI  - IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice
T2  - Communications Biology
UR  - http://dx.doi.org/10.1038/s42003-021-01703-3
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000616324800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s42003-021-01703-3
UR  - http://hdl.handle.net/10044/1/88120
VL  - 4
ER  -
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