Publications
160 results found
Saglani S, Payne DN, Zhu J, et al., 2007, Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 176, Pages: 858-864, ISSN: 1073-449X
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- Citations: 363
Tsoumakidou M, Zhu J, Wang Z, et al., 2007, Immunohistochemical detection of dendritic cells in human lung tissue, HISTOPATHOLOGY, Vol: 51, Pages: 565-568, ISSN: 0309-0167
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- Citations: 5
Ferrari S, Griesenbach U, Iida A, et al., 2007, Sendai virus-mediated CFTR gene transfer to the airway epithelium, GENE THERAPY, Vol: 14, Pages: 1371-1379, ISSN: 0969-7128
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- Citations: 49
Gamble E, Grootendorst DC, Hattotuwa K, et al., 2007, Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: a pooled analysis, EUROPEAN RESPIRATORY JOURNAL, Vol: 30, Pages: 467-471, ISSN: 0903-1936
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- Citations: 107
Zhu J, Qiu Y, Valobra M, et al., 2007, Plasma cells and IL-4 in chronic bronchitis and chronic obstructive pulmonary disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 175, Pages: 1125-1133, ISSN: 1073-449X
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- Citations: 36
Regamey N, Hilliard TN, Saglani S, et al., 2007, Quality, size, and composition of pediatric endobronchial biopsies in cystic fibrosis, CHEST, Vol: 131, Pages: 1710-1717, ISSN: 0012-3692
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- Citations: 27
Qiu Y, Zhu J, Bandi V, et al., 2007, Bronchial mucosal inflammation and upregulation of CXC chemoattractants and receptors in severe exacerbations of asthma, THORAX, Vol: 62, Pages: 475-482, ISSN: 0040-6376
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- Citations: 89
Tsoumakidou M, Elston W, Zhu J, et al., 2007, Cigarette smoking alters bronchial mucosal immunity in asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 175, Pages: 919-925, ISSN: 1073-449X
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- Citations: 60
Xenariou S, Griesenbach U, Liang H-D, et al., 2007, Use of ultrasound to enhance nonviral lung gene transfer in vivo, GENE THERAPY, Vol: 14, Pages: 768-774, ISSN: 0969-7128
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- Citations: 59
Molfino NA, Jeffery PK, 2007, Chronic obstructive pulmonary disease: Histopathology, inflammation and potential therapies, PULMONARY PHARMACOLOGY & THERAPEUTICS, Vol: 20, Pages: 462-472, ISSN: 1094-5539
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- Citations: 31
Holder E, Griesenbach U, Li S, et al., 2006, Intravenously administered oligonucleotides can be delivered to conducting airway epithelium via the bronchial circulation, GENE THERAPY, Vol: 13, Pages: 1628-1638, ISSN: 0969-7128
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- Citations: 6
Jeffery PK, Haahtela T, 2006, Allergic rhinitis and asthma: inflammation in a one-airway condition., BMC Pulm Med, Vol: 6 Suppl 1
BACKGROUND: Allergic rhinitis and asthma are conditions of airway inflammation that often coexist. DISCUSSION: In susceptible individuals, exposure of the nose and lungs to allergen elicits early phase and late phase responses. Contact with antigen by mast cells results in their degranulation, the release of selected mediators, and the subsequent recruitment of other inflammatory cell phenotypes. Additional proinflammatory mediators are released, including histamine, prostaglandins, cysteinyl leukotrienes, proteases, and a variety of cytokines, chemokines, and growth factors. Nasal biopsies in allergic rhinitis demonstrate accumulations of mast cells, eosinophils, and basophils in the epithelium and accumulations of eosinophils in the deeper subepithelium (that is, lamina propria). Examination of bronchial tissue, even in mild asthma, shows lymphocytic inflammation enriched by eosinophils. In severe asthma, the predominant pattern of inflammation changes, with increases in the numbers of neutrophils and, in many, an extension of the changes to involve smaller airways (that is, bronchioli). Structural alterations (that is, remodeling) of bronchi in mild asthma include epithelial fragility and thickening of its reticular basement membrane. With increasing severity of asthma there may be increases in airway smooth muscle mass, vascularity, interstitial collagen, and mucus-secreting glands. Remodeling in the nose is less extensive than that of the lower airways, but the epithelial reticular basement membrane may be slightly but significantly thickened. CONCLUSION: Inflammation is a key feature of both allergic rhinitis and asthma. There are therefore potential benefits for application of anti-inflammatory strategies that target both these anatomic sites.
Saglani S, Molyneux C, Gong H, et al., 2006, Ultrastructure of the reticular basement membrane in asthmatic adults, children and infants, EUROPEAN RESPIRATORY JOURNAL, Vol: 28, Pages: 505-512, ISSN: 0903-1936
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- Citations: 51
Xenariou S, Liang H-D, Griesenbach U, et al., 2006, Low-Frequency Ultrasound Increases Non-Viral Lung Gene Transfer, MOLECULAR THERAPY, Vol: 13, Pages: S269-S269, ISSN: 1525-0016
Barnes NC, Qiu YS, Pavord ID, et al., 2006, Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 173, Pages: 736-743, ISSN: 1073-449X
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- Citations: 202
Saglani S, Papaioannou G, Khoo L, et al., 2006, Can HRCT be used as a marker of airway remodelling in children with difficult asthma?, Respiratory Research, Vol: 7, ISSN: 1465-993X
Background: Whole airway wall thickening on high resolution computed tomography (HRCT) isreported to parallel thickening of the bronchial epithelial reticular basement membrane (RBM) inadult asthmatics. A similar relationship in children with difficult asthma (DA), in whom RBMthickening is a known feature, may allow the use of HRCT as a non-invasive marker of airwayremodelling. We evaluated this relationship in children with DA.Methods: 27 children (median age 10.5 [range 4.1–16.7] years) with DA, underwentendobronchial biopsy from the right lower lobe and HRCT less than 4 months apart. HRCTs wereassessed for bronchial wall thickening (BWT) of the right lower lobe using semi-quantitative andquantitative scoring techniques. The semi-quantitative score (grade 0–4) was an overall assessmentof BWT of all clearly identifiable airways in HRCT scans. The quantitative score (BWT %; definedas [airway outer diameter – airway lumen diameter]/airway outer diameter ×100) was the averagescore of all airways visible and calculated using electronic endpoint callipers. RBM thickness inendobronchial biopsies was measured using image analysis. 23/27 subjects performed spirometryand the relationships between RBM thickness and BWT with airflow obstruction evaluated.Results: Median RBM thickness in endobronchial biopsies was 6.7(range 4.6 – 10.0) µm. Medianqualitative score for BWT of the right lower lobe was 1(range 0 – 1.5) and quantitative score was54.3 (range 48.2 – 65.6)%. There was no relationship between RBM thickness and BWT in the rightlower lobe using either scoring technique. No relationship was found between FEV1 and BWT orRBM thickness.Conclusion: Although a relationship between RBM thickness and BWT on HRCT has been foundin adults with asthma, this relationship does not appear to hold true in children with DA.
Gamble E, Qiu Y, Wang D, et al., 2006, Variability of bronchial inflammation in chronic obstructive pulmonary disease: implications for study design, EUROPEAN RESPIRATORY JOURNAL, Vol: 27, Pages: 293-299, ISSN: 0903-1936
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- Citations: 30
Zhu L, Qiu YS, Figueroa DJ, et al., 2005, Localization and upregulation of cysteinyl leukotriene-1 receptor in asthmatic bronchial mucosa, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 33, Pages: 531-540, ISSN: 1044-1549
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- Citations: 65
Ulrich K, Stern M, Goddard ME, et al., 2005, Keratinocyte growth factor therapy in murine oleic acid-induced acute lung injury, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 288, Pages: L1179-L1192, ISSN: 1040-0605
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- Citations: 47
Saglani S, Malmstrôm K, Pelkonen AS, et al., 2005, Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 171, Pages: 722-727, ISSN: 1073-449X
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- Citations: 282
Ferrari S, Griesenbach U, Shirai-Iida T, et al., 2004, A defective nontransmissible recombinant Sendai virus mediates efficient gene transfer to airway epithelium in vivo, GENE THERAPY, Vol: 11, Pages: 1659-1664, ISSN: 0969-7128
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- Citations: 44
Payne DNR, Qiu Y, Zhu J, et al., 2004, Airway inflammation in children with difficult asthma: relationships with airflow limitation and persistent symptoms, THORAX, Vol: 59, Pages: 862-869, ISSN: 0040-6376
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- Citations: 79
Elston WJ, Whittaker AJ, Khan LN, et al., 2004, Safety of research bronchoscopy, biopsy and bronchoalveolar lavage in asthma, EUROPEAN RESPIRATORY JOURNAL, Vol: 24, Pages: 375-377, ISSN: 0903-1936
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- Citations: 62
Degabriele NM, Griesenbach U, Sato K, et al., 2004, Critical appraisal of the mouse model of myocardial infarction, EXPERIMENTAL PHYSIOLOGY, Vol: 89, Pages: 497-505, ISSN: 0958-0670
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- Citations: 34
Jeffery PK, 2004, Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease., Proc Am Thorac Soc, Vol: 1, Pages: 176-183, ISSN: 1546-3222
Asthma and chronic obstructive pulmonary disease (COPD) are pathologically distinct in terms of their predominant inflammatory cells and structural alterations (i.e., remodeling). However, there are many cases of functional and pathologic overlap, supporting the author's view that use of the terms asthma or COPD is oversimplistic and fails to identify the range of phenotypes that exist. In general, there is epithelial fragility and thickening of the reticular basement membrane, even in mild asthma; increased airway smooth muscle mass, hypertrophy of mucus-secreting glands, increased vascularity, greater numbers of fibroblasts, and increased deposition of collagen in severe asthma and COPD; and mucous metaplasia, squamous metaplasia, and parenchymal destruction in COPD. Because of increased neutrophilia, patterns of inflammation become similar when exacerbations of asthma and COPD result in hospitalization. Moreover, in mild COPD, exacerbations of bronchitis are associated with mucosal eosinophilia and upregulation of RANTES, two features normally associated with asthma. The overlap may also be seen in intermediate thickening of the reticular basement membrane and eosinophilia in patients with COPD who demonstrate reversibility to oral steroid. Importantly, a recent study of "eosinophilic bronchitis" demonstrates a thickened reticular basement membrane and challenges our current concept of the histopathologic distinctions between asthma and COPD.
Gamble E, Burns W, Zhu J, et al., 2003, Variation of CD8+ T-lymphocytes around the bronchial internal perimeter in chronic bronchitis, EUROPEAN RESPIRATORY JOURNAL, Vol: 22, Pages: 992-995, ISSN: 0903-1936
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- Citations: 10
Gamble E, Grootendorst DC, Brightling CE, et al., 2003, Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 168, Pages: 976-982, ISSN: 1073-449X
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- Citations: 161
Qiu YS, Zhu J, Bandi V, et al., 2003, Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 168, Pages: 968-975, ISSN: 1073-449X
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- Citations: 252
Jeffery P, Holgate S, Wenzel S, et al., 2003, Methods for the assessment of endobronchial biopsies in clinical research: application to studies of pathogenesis and the effects of treatment., Am J Respir Crit Care Med, Vol: 168, Pages: S1-17, ISSN: 1073-449X
Payne DNR, Rogers AV, Ädelroth E, et al., 2003, Early thickening of the reticular basement membrane in children with difficult asthma, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 167, Pages: 78-82, ISSN: 1073-449X
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- Citations: 378
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