Imperial College London
Alternate

Emeritus ProfessorPeterJeffery

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor
 
 
 
//

Contact

 

p.jeffery

 
 
//

Location

 

Medical SchoolSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{O'Reilly:2012:10.1016/j.jaci.2012.08.044,
author = {O'Reilly, R and Ullmann, N and Irving, S and Bossley, C and Sonnappa, S and Zhu, J and Oates, T and Banya, W and Jeffery, PK and Bush, A and Saglani, S},
doi = {10.1016/j.jaci.2012.08.044},
journal = {J Allergy Clin Immunol},
title = {Increased airway smooth muscle in preschool wheezers who have asthma at school age.},
url = {http://dx.doi.org/10.1016/j.jaci.2012.08.044},
year = {2012}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Increased airway smooth muscle (ASM) is a feature of established asthma in schoolchildren, but nothing is known about ASM in preschool wheezers.OBJECTIVE: We sought to determine endobronchial biopsy specimen ASM area fraction in preschool wheezers and its association with asthma at school age.METHODS: ASM area, reticular basement membrane thickness, and mucosal eosinophil and ASM mast cell values were quantified in endobronchial biopsy specimens previously obtained from preschool children undergoing clinically indicated bronchoscopy: severe recurrent wheezers (n = 47; median age, 26 months) and nonwheezing control subjects (n = 21; median age, 15 months). Children were followed up, and asthma status was established at age 6 to 11 years. Preschool airway pathology was examined in relation to asthma at school age.RESULTS: Forty-two (62%) of 68 children had 1 or more evaluable biopsy specimens for ASM. At school age, 51 of 68 children were followed up, and 15 (40%) of 37 preschool wheezers had asthma. Children who had asthma and an evaluable biopsy specimen had increased preschool ASM area fraction (n = 8; median age, 8.2 years [range, 6-10.4 years]; median ASM, 0.12 [range, 0.08-0.16]) compared with that seen in children without asthma (n = 24; median age, 7.3 years [range, 5.9-11 years]; median ASM, 0.07 [range, 0.02-0.23]; P = .007). However, preschool reticular basement membrane thickness and mucosal eosinophil or ASM mast cell values were not different between those who did or did not have asthma at school age.CONCLUSION: Increased preschool ASM is associated with those children who have asthma at school age. Thus a focus on early changes in ASM might be important in understanding the subsequent development of childhood asthma.
AU  - O'Reilly,R
AU  - Ullmann,N
AU  - Irving,S
AU  - Bossley,C
AU  - Sonnappa,S
AU  - Zhu,J
AU  - Oates,T
AU  - Banya,W
AU  - Jeffery,PK
AU  - Bush,A
AU  - Saglani,S
DO  - 10.1016/j.jaci.2012.08.044
PY  - 2012///
TI  - Increased airway smooth muscle in preschool wheezers who have asthma at school age.
T2  - J Allergy Clin Immunol
UR  - http://dx.doi.org/10.1016/j.jaci.2012.08.044
ER  -
Download