Imperial College London
Dr Peter Jenkins

DrPeterJenkins

Faculty of Medicine, Department of Brain Sciences

Honorary Clinical Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 8064p.jenkins Website

 
 
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Location

 

C3NL LaboratoryBurlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bourke:2021:braincomms/fcab006,
author = {Bourke, N and Yanez-Lopez, M and Jenkins, P and De, Simoni S and Cole, J and Lally, P and Mallas, E and Zhang, H and Sharp, D},
doi = {braincomms/fcab006},
journal = {Brain Communications},
title = {Traumatic brain injury: a comparison of diffusion and volumetric magnetic resonance imaging measures},
url = {http://dx.doi.org/10.1093/braincomms/fcab006},
volume = {3},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cognitive impairment following traumatic brain injury remains hard to predict. This is partly because axonal injury, which is of fundamental importance, is difficult to measure clinically. Advances in MRI allow axonal injury to be detected after traumatic brain injury, but the most sensitive approach is unclear. Here we compare the performance of diffusion tensor imaging, neurite orientation dispersion and density-imaging and volumetric measures of brain atrophy in the identification of white matter abnormalities after traumatic brain injury.Thirty patients with moderate-severe traumatic brain injury in the chronic phase and 20 age-matched controls had T1-weighted and diffusion MRI. Neuropsychological tests of processing speed, executive functioning and memory were used to detect cognitive impairment.Extensive abnormalities in neurite density index and orientation dispersion index were observed, with distinct spatial patterns. Fractional anisotropy and mean diffusivity also indicated widespread abnormalities of white matter structure. Neurite density index was significantly correlated with processing speed. Slower processing speed was also related to higher mean diffusivity in the cortico-spinal tracts. Lower white matter volumes were seen following brain injury with greater effect sizes compared to diffusion metrics however volume was not sensitive to changes in cognitive performance.Volume was the most sensitive at detecting change between groups but was not specific for determining relationships with cognition. Abnormalities in fractional anisotropy and mean diffusivity were the most sensitive diffusion measures, however neurite density index and orientation dispersion index may be more spatially specific. Lower neurite density index may be a useful metric for examining slower processing speed.
AU  - Bourke,N
AU  - Yanez-Lopez,M
AU  - Jenkins,P
AU  - De,Simoni S
AU  - Cole,J
AU  - Lally,P
AU  - Mallas,E
AU  - Zhang,H
AU  - Sharp,D
DO  - braincomms/fcab006
PY  - 2021///
SN  - 2632-1297
TI  - Traumatic brain injury: a comparison of diffusion and volumetric magnetic resonance imaging measures
T2  - Brain Communications
UR  - http://dx.doi.org/10.1093/braincomms/fcab006
UR  - http://hdl.handle.net/10044/1/86015
VL  - 3
ER  -
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