Imperial College London
Alternate

Dr. Patrik R. Jones

Faculty of Natural Sciences, Department of Life Sciences

Professor of Metabolic Engineering
 
 
 
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Contact

 

+44 (0)20 7594 5213p.jones

 
 
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Location

 

503Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Erb:2017:10.1016/j.cbpa.2016.12.023,
author = {Erb, TJ and Jones, PR and Bar-Even, A},
doi = {10.1016/j.cbpa.2016.12.023},
journal = {Current Opinion in Chemical Biology},
pages = {56--62},
title = {Synthetic metabolism: metabolic engineering meets enzyme design.},
url = {http://dx.doi.org/10.1016/j.cbpa.2016.12.023},
volume = {37},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Metabolic engineering aims at modifying the endogenous metabolic network of an organism to harness it for a useful biotechnological task, for example, production of a value-added compound. Several levels of metabolic engineering can be defined and are the topic of this review. Basic 'copy, paste and fine-tuning' approaches are limited to the structure of naturally existing pathways. 'Mix and match' approaches freely recombine the repertoire of existing enzymes to create synthetic metabolic networks that are able to outcompete naturally evolved pathways or redirect flux toward non-natural products. The space of possible metabolic solution can be further increased through approaches including 'new enzyme reactions', which are engineered on the basis of known enzyme mechanisms. Finally, by considering completely 'novel enzyme chemistries' with de novo enzyme design, the limits of nature can be breached to derive the most advanced form of synthetic pathways. We discuss the challenges and promises associated with these different metabolic engineering approaches and illuminate how enzyme engineering is expected to take a prime role in synthetic metabolic engineering for biotechnology, chemical industry and agriculture of the future.
AU  - Erb,TJ
AU  - Jones,PR
AU  - Bar-Even,A
DO  - 10.1016/j.cbpa.2016.12.023
EP  - 62
PY  - 2017///
SN  - 1879-0402
SP  - 56
TI  - Synthetic metabolism: metabolic engineering meets enzyme design.
T2  - Current Opinion in Chemical Biology
UR  - http://dx.doi.org/10.1016/j.cbpa.2016.12.023
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28152442
UR  - http://hdl.handle.net/10044/1/45321
VL  - 37
ER  -
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