Imperial College London


Faculty of MedicineDepartment of Infectious Disease

Professor of Virus Genomics







460Wright Fleming WingSt Mary's Campus





Paul Kellam is the  Professor of Virus Genomics at Imperial College London and Vice President of infectious diseases & vaccines at Kymab Ltd, UK. He has published over 200 primary research papers, reviews, book chapters and patents. Paul Is a Fellow of the American Academy of Microbiology and Council Member of the UK Microbiology Society.

Paul’s scientific career has spanned the pharmaceutical industry, at the Wellcome Foundation Ltd and Kymab Ltd and academia, where Paul was the Virus Genomics lead at the Wellcome Trust Sanger Institute and a Professor of Virology at UCL. 

Paul’s research has identified how HIV develops resistance to antiviral drugs and has identified the first influenza disease severity gene in people hospitalised with influenza virus. His laboratory produced the virus genome analysis of the Middle East Respiratory Syndrome Coronavirus (MERS CoV) outbreaks working with the Department of Health in Saudi Arabia, showing that the transmission pattern of the virus was consistent with multiple transfer events from an animal reservoir and contributing to the identification of camels as the animal reservoir. His laboratory contributed to the international Ebola virus genome analysis to help the WHO control the outbreak and to show the factors influencing virus transmission.

In 2016 Paul became the Professor of Virus Genomics at Imperial College London and the Vice President of Infectious Diseases & Vaccines at Kymab Ltd. The Imperial College laboratory is continuing its research theme of investigating virus and host genetic variation during infection. At Kymab Pauls’ work is focusing on using the Kymouse to develop therapeutic antibody treatments of infectious diseases and to further advance vaccine research.



Wymant C, Bezemer D, Blanquart F, et al., 2022, A highly virulent variant of HIV-1 circulating in the Netherlands, Science, Vol:375, ISSN:0036-8075, Pages:540-+

Hastie KM, Li H, Bedinger D, et al., 2021, Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study, Science, Vol:374, ISSN:0036-8075, Pages:472-+

van Bunnik BAD, Morgan ALK, Bessell PR, et al., 2021, Segmentation and shielding of the most vulnerable members of the population as elements of an exit strategy from COVID-19 lockdown, Philosophical Transactions of the Royal Society B-biological Sciences, Vol:376, ISSN:0962-8436

Roach M, Cantu A, Vieri MK, et al., 2021, No evidence known viruses play a role in the pathogenesis of onchocerciasis-associated epilepsy. An explorative metagenomic case-control study, Pathogens, Vol:10

Walls AC, Fiala B, Schäfer A, et al., 2020, Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2, Cell, Vol:183, ISSN:0092-8674, Pages:1367-1382.e17

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