Imperial College London
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ProfessorPaulKellam

Faculty of Medicine, Department of Infectious Disease

Professor of Virus Genomics
 
 
 
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p.kellam

 
 
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Location

 

460Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Petrova:2019:10.1126/sciimmunol.aay6125,
author = {Petrova, VN and Sawatsky, B and Han, AX and Laksono, BM and Walz, L and Parker, E and Pieper, K and Anderson, CA and de, Vries RD and Lanzavecchia, A and Kellam, P and von, Messling V and de, Swart RL and Russell, CA},
doi = {10.1126/sciimmunol.aay6125},
journal = {Science Immunology},
pages = {1--14},
title = {Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles},
url = {http://dx.doi.org/10.1126/sciimmunol.aay6125},
volume = {4},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Measles is a disease caused by the highly infectious measles virus (MeV) that results in both viremia and lymphopenia. Lymphocyte counts recover shortly after the disappearance of measles-associated rash, but immunosuppression can persist for months to years after infection, resulting in increased incidence of secondary infections. Animal models and in vitro studies have proposed various immunological factors underlying this prolonged immune impairment, but the precise mechanisms operating in humans are unknown. Using B cell receptor (BCR) sequencing of human peripheral blood lymphocytes before and after MeV infection, we identified two immunological consequences from measles underlying immunosuppression: (i) incomplete reconstitution of the naïve B cell pool leading to immunological immaturity and (ii) compromised immune memory to previously encountered pathogens due to depletion of previously expanded B memory clones. Using a surrogate model of measles in ferrets, we investigated the clinical consequences of morbillivirus infection and demonstrated a depletion of vaccine-acquired immunity to influenza virus, leading to a compromised immune recall response and increased disease severity after secondary influenza virus challenge. Our results show that MeV infection causes changes in naïve and memory B lymphocyte diversity that persist after the resolution of clinical disease and thus contribute to compromised immunity to previous infections or vaccinations. This work highlights the importance of MeV vaccination not only for the control of measles but also for the maintenance of herd immunity to other pathogens, which can be compromised after MeV infection.
AU  - Petrova,VN
AU  - Sawatsky,B
AU  - Han,AX
AU  - Laksono,BM
AU  - Walz,L
AU  - Parker,E
AU  - Pieper,K
AU  - Anderson,CA
AU  - de,Vries RD
AU  - Lanzavecchia,A
AU  - Kellam,P
AU  - von,Messling V
AU  - de,Swart RL
AU  - Russell,CA
DO  - 10.1126/sciimmunol.aay6125
EP  - 14
PY  - 2019///
SN  - 2470-9468
SP  - 1
TI  - Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles
T2  - Science Immunology
UR  - http://dx.doi.org/10.1126/sciimmunol.aay6125
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000493925300002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://immunology.sciencemag.org/content/4/41/eaay6125
VL  - 4
ER  -
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