Imperial College London
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ProfessorPaulKellam

Faculty of Medicine, Department of Infectious Disease

Professor of Virus Genomics
 
 
 
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Contact

 

p.kellam

 
 
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Location

 

460Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kellam:2020:10.1099/jgv.0.001439,
author = {Kellam, P and Barclay, W},
doi = {10.1099/jgv.0.001439},
journal = {Journal of General Virology},
title = {The dynamics of humoral immune responses following SARS-CoV-2 infection and the potential for reinfection},
url = {http://dx.doi.org/10.1099/jgv.0.001439},
volume = {101},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - SARS-CoV-2 is a novel coronavirus that is the causative agent of coronavirus infectious disease 2019 (COVID-19). As of 17 April 2020, it has infected 2114269 people, resulting in 145144 deaths. The timing, magnitude and longevity of humoral immunity is not yet understood for SARS-CoV-2. Nevertheless, understanding this is urgently required to inform the likely future dynamics of the pandemic, to guide strategies to allow relaxation of social distancing measures and to understand how to deploy limiting vaccine doses when they become available to achieve maximum impact. SARS-CoV-2 is the seventh human coronavirus to be described. Four human coronaviruses circulate seasonally and cause common colds. Two other coronaviruses, SARS and MERS, have crossed from animal sources into humans but have not become endemic. Here we review what is known about the human humoral immune response to epidemic SARS CoV and MERS CoV and to the seasonal, endemic coronaviruses. Then we summarize recent, mostly non-peer reviewed, studies into SARS-CoV-2 serology and reinfection in humans and non-human primates and summarize current pressing research needs.
AU  - Kellam,P
AU  - Barclay,W
DO  - 10.1099/jgv.0.001439
PY  - 2020///
SN  - 0022-1317
TI  - The dynamics of humoral immune responses following SARS-CoV-2 infection and the potential for reinfection
T2  - Journal of General Virology
UR  - http://dx.doi.org/10.1099/jgv.0.001439
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32430094
UR  - http://hdl.handle.net/10044/1/81329
VL  - 101
ER  -
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