Imperial College London
Portrait Picture

ProfessorPaulKellam

Faculty of Medicine, Department of Infectious Disease

Professor of Virus Genomics
 
 
 
//

Contact

 

p.kellam

 
 
//

Location

 

460Wright Fleming WingSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Wymant:2022:10.1126/science.abk1688,
author = {Wymant, C and Bezemer, D and Blanquart, F and Ferretti, L and Gall, A and Hall, M and Golubchik, T and Bakker, M and Ong, SH and Zhao, L and Bonsall, D and de, Cesare M and MacIntyre-Cockett, G and Abeler-Doerner, L and Albert, J and Bannert, N and Fellay, J and Grabowski, MK and Gunsenheimer-Bartmeyer, B and Gunthard, HF and Kivela, P and Kouyos, RD and Laeyendecker, O and Meyer, L and Porter, K and Ristola, M and van, Sighem A and Ben, B and Kellam, P and Cornelissen, M and Reiss, P and Fraser, C},
doi = {10.1126/science.abk1688},
journal = {Science},
pages = {540--545},
title = {A highly virulent variant of HIV-1 circulating in the Netherlands},
url = {http://dx.doi.org/10.1126/science.abk1688},
volume = {375},
year = {2022}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Changes in viral load and CD4+ T cell decline are expected signals of HIV evolution. By examining data from well-characterized European cohorts, Wymant et al. report an exceptionally virulent subtype of HIV that has been circulating in the Netherlands for several years (see the Perspective by Wertheim). More than one hundred individuals infected with a characteristic subtype B lineage of HIV-1 were found who experienced double the rate of CD4+ cell count declines than expected. By the time they were diagnosed, these individuals were vulnerable to developing AIDS within 2 to 3 years. This virus lineage, which has apparently arisen de novo since around the millennium, shows extensive change across the genome affecting almost 300 amino acids, which makes it hard to discern the mechanism for elevated virulence. —CA
AU  - Wymant,C
AU  - Bezemer,D
AU  - Blanquart,F
AU  - Ferretti,L
AU  - Gall,A
AU  - Hall,M
AU  - Golubchik,T
AU  - Bakker,M
AU  - Ong,SH
AU  - Zhao,L
AU  - Bonsall,D
AU  - de,Cesare M
AU  - MacIntyre-Cockett,G
AU  - Abeler-Doerner,L
AU  - Albert,J
AU  - Bannert,N
AU  - Fellay,J
AU  - Grabowski,MK
AU  - Gunsenheimer-Bartmeyer,B
AU  - Gunthard,HF
AU  - Kivela,P
AU  - Kouyos,RD
AU  - Laeyendecker,O
AU  - Meyer,L
AU  - Porter,K
AU  - Ristola,M
AU  - van,Sighem A
AU  - Ben,B
AU  - Kellam,P
AU  - Cornelissen,M
AU  - Reiss,P
AU  - Fraser,C
DO  - 10.1126/science.abk1688
EP  - 545
PY  - 2022///
SN  - 0036-8075
SP  - 540
TI  - A highly virulent variant of HIV-1 circulating in the Netherlands
T2  - Science
UR  - http://dx.doi.org/10.1126/science.abk1688
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000753965100039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.science.org/doi/10.1126/science.abk1688
VL  - 375
ER  -
Download