Summary
Peter Kelleher is a graduate of Trinity College Dublin. He trained in internal medicine in Dublin and clinical immunology in London and Oxford. His PhD thesis on dendritic cell function in retroviral infection was conducted under the supervision of Professor Stella Knight at the APRG Unit, Imperial College London. Dr Kelleher research interests are in the immunology of HIV-1 infection and primary antibody deficiency and the application of novel immunological technologies to the diagnosis of patients with infectious diseases and immune based disorders. Current research interests include studies evaluating the contribution of HIV-1 specific antibody responses in acquistion of HIV-1 and control of acute HIV infection in high risk men who have sex with men. We also focus on defects in B cell memory may underlie the risks of invasive bacterial disease and impaired bacterial vaccine responses in HIV-1 infection. The laboratory is the investigation of novel immune defect in patients with primary antibody deficiency. The immunology laboratory is also involved in multi-centre clincal and laboratory based studies European and UK in patient with HIV-1 infection, CVID,complement deficiencies and ventilator associated pneumonia.
Dr Kelleher holds honorary consultant positions with the HIV & Sexual Directorate at the Chelsea & Westminster NHS Foundation Trust, the Department of Respiratory Medicine, Royal Brompton & Harefield NHS Trust and the Department of Infection & Immunity at Imperial College Healthcare NHS Trust. His NHS duties include provision of clinics for patients with primary immune deficiencies and HIV-1 infection and the direction of diagnostic Immunology Laboratories at Imperial College Healthcare NHS Trust.
Selected Publications
Journal Articles
de Lavallade H, Khoder A, Hart M, et al., 2013, Tyrosine kinase inhibitors impair B-cell immune responses in CML through off-target inhibition of kinases important for cell signaling, Blood, Vol:122, ISSN:0006-4971, Pages:227-238
Page E, Greathead L, Hart M, et al., 2013, Alterations in the balance of Th1 (CXCR3+CCR5+) cells to Th17 (CCR4+CCR6+CCR10-) and Th22 (CCR4+CCR6+CCR10+) cells in HIV-1/HCV coinfection is associated with immune activation, microbial translocation and liver fibrosis, HIV Medicine, Vol:14, ISSN:1464-2662, Pages:3-3
Paton NI, Goodall RL, Dunn DT, et al., 2012, Effects of Hydroxychloroquine on Immune Activation and Disease Progression Among HIV-Infected Patients Not Receiving Antiretroviral Therapy A Randomized Controlled Trial, JAMA - Journal of the American Medical Association, Vol:308, ISSN:0098-7484, Pages:353-361
Clark S, Page E, Ford T, et al., 2011, Reduced T<sub>H</sub>1/T<sub>H</sub>17 CD4 T-cell numbers are associated with impaired purified protein derivative-specific cytokine responses in patients with HIV-1 infection, Journal of Allergy and Clinical Immunology, Vol:128, ISSN:0091-6749, Pages:838-U547
Beirne P, Pantelidis P, Charles P, et al., 2009, Multiplex immune serum biomarker profiling in sarcoidosis and systemic sclerosis, European Respiratory Journal, Vol:34, ISSN:0903-1936, Pages:1376-1382
Bower M, Veraitch O, Szydlo R, et al., 2009, Cytokine changes during rituximab therapy in HIV-associated multicentric Castleman disease, Blood, Vol:113, ISSN:0006-4971, Pages:4521-4524
Bower M, Powles T, Williams S, et al., 2007, Brief communication: Rituximab in HIV-associated multicentric Castleman disease, Annals of Internal Medicine, Vol:147, ISSN:0003-4819, Pages:836-839
Clark SA, Martin SL, Pozniak A, et al., 2007, Tuberculosis antigen-specific immune responses can be detected using enzyme-linked immunospot technology in human immunodeficiency virus (HIV)-1 patients with advanced disease, Clinical and Experimental Immunology, Vol:150, ISSN:0009-9104, Pages:238-244
Hart M, Steel A, Clark SA, et al., 2007, Loss of discrete memory B cell subsets is associated with impaired immunization responses in HIV-1 infection and may be a risk factor for invasive pneumococcal disease, Journal of Immunology, Vol:178, ISSN:0022-1767, Pages:8212-8220
Steel A, Cox AE, Shamji MH, et al., 2007, HIV-1 viral replication below 50 copies/ml in patients on antiretroviral therapy is not associated with CD8<SUP>+</SUP> T-cell activation, Antiviral Therapy, Vol:12, ISSN:1359-6535, Pages:971-975
Steel A, Clark S, Teo I, et al., 2006, No change to HIV-1 latency with valproate therapy, AIDS, Vol:20, ISSN:0269-9370, Pages:1681-1682
Kelleher P, Goodsall A, Mulgirigama A, et al., 2006, Interferon-gamma therapy in two patients with progressive chronic pulmonary aspergillosis, European Respiratory Journal, Vol:27, ISSN:0903-1936, Pages:1307-1310