Publications
161 results found
Benlahrech A, Yasmin A, Westrop SJ, et al., 2012, Dysregulated immunophenotypic attributes of plasmacytoid but not myeloid dendritic cells in HIV-1 infected individuals in the absence of highly active anti-retroviral therapy, Clinical and Experimental Immunology, Vol: 170, Pages: 212-221, ISSN: 0009-9104
Dendritic cells (DC) in HIV-1-infected individuals are decreased and their dysfunction has been implicated in HIV-1 immunopathogenesis. The mechanism of their dysfunction remains unclear, thus we analysed the expression of membrane molecules associated with immune regulation and DC activation in myeloid (mDC) and plasmacytoid DC (pDC) in therapy-naive and highly active anti-retroviral therapy (HAART)-treated HIV-1+ patients. DC from healthy controls, untreated HIV-1+ and HAART-treated patients were assessed by flow cytometry for expression of: anergy and apoptosis inducing molecules [programmed death (PD)-1 and its ligands PD-L1 and PD-L2], inhibitory and regulatory T cell-inducing molecules [immunoglobulin-like transcript (ILT)-3 and ILT-4], interferon (IFN)-α inhibitory receptor (ILT-7) and co-stimulatory molecules (CD80, CD83, and CD86). pDC from untreated HIV-1+ patients expressed significantly lower levels of ILT-7 compared to healthy controls, while HAART-treated patients showed normal expression. pDC were also found to express moderately higher levels of PD-L1 and ILT-3 and lower levels of PD-L2 receptors in untreated patients compared to controls and HAART-treated patients. No significant changes were observed in mDC. There were no associations between the percentages and levels of expression of these molecules by pDC and viral load or CD4 T cell count. In conclusion, pDC but not mDC from HIV-1+ patients with active viraemia display higher levels of apoptosis and T regulatory-inducing molecules and may be predisposed to chronically produce IFN-α through down-regulation of ILT-7. HAART restored normal expression levels of these receptors.
Greathead L, Cheeseman H, Steel A, et al., 2012, Elevated expression of TH17-associated cytokines in the colon of active ulcerative colitis, European Congress of Immunology, Publisher: WILEY-BLACKWELL, Pages: 530-531, ISSN: 0019-2805
Metcalf R, Clark SA, Graeme C, et al., 2012, Correlates of immune protection in <i>Mycobacterium tuberculosis</i>, European Congress of Immunology, Publisher: WILEY-BLACKWELL, Pages: 596-597, ISSN: 0019-2805
Gurney S, Graham C, Metcalf R, et al., 2012, TREM-1 expression is elevated on monocytes in cirrhotic patients, European Congress of Immunology, Publisher: WILEY-BLACKWELL, Pages: 511-511, ISSN: 0019-2805
Paton NI, Goodall RL, Dunn DT, et al., 2012, Effects of Hydroxychloroquine on Immune Activation and Disease Progression Among HIV-Infected Patients Not Receiving Antiretroviral Therapy A Randomized Controlled Trial, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 308, Pages: 353-361, ISSN: 0098-7484
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- Citations: 121
Bao T, Betts K, Tarpinian K, et al., 2012, Changes in patient-reported outcomes in women with breast cancer in a multicenter double-blind randomized controlled trial assessing the effect of acupuncture in reducing aromatase inhibitor-induced musculoskeletal symptoms (AIMSS), 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
Manson AL, Zaheri S, Kelleher P, et al., 2012, Management of granulomatous common variable immunodeficiency diagnosed in pregnancy: a case report, JOURNAL OF PERINATOLOGY, Vol: 32, Pages: 387-389, ISSN: 0743-8346
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- Citations: 6
Rawson T, Mandalia S, Pozniak A, et al., 2012, CD8 T-Cells in HIV related neurocognitive impairment (NCI), HIV MEDICINE, Vol: 13, Pages: 54-54, ISSN: 1464-2662
Elliot E, McCowan A, Cox A, et al., 2012, Can EDTA samples be used to measure CD4 counts at the weekend?, HIV MEDICINE, Vol: 13, Pages: 77-78, ISSN: 1464-2662
Grover V, Soni N, Kelleher P, et al., 2012, Biomarkers in the diagnosis of ventilator-associated pneumonia, Current Respiratory Medicine Reviews, Vol: 8, Pages: 184-192, ISSN: 1573-398X
Ventilator Associated Pneumonia (VAP) is a common nosocomial infection in the ICU. Diagnosis based on best available criteria remains difficult. Current and novel biomarkers have the potential to speed up and improve the accuracy of its diagnosis. This review highlights the markers that have gained the most attention to date and aims to discuss the challenges faced in introducing them at the bedside. © 2012 Bentham Science Publishers.
Kelleher P, Wilson R, 2012, Antibody deficiency, Sarcoidosis, Pages: 361-369, ISBN: 9780340992111
Primary immunodeficiency disorders (PIDs) comprise many diseases caused by genetic defects affecting the immune system. Over the last 25 years, 214 diseases have been identified with more than 120 genetic defects identified to date (Notarangelo et al. 2007). The incidence of PIDs is low, but their prevalence can range from 1 in 500 to 1 in 500000 in the general population depending on clinical awareness and medical resources available in different countries. Multi- organ granulomatous disease of unknown etiology can occur in a number of PID including common variable immune deficiency (CVID), severe combined immunodeficiency, ataxia telangiectasia, Wiskott Aldrich syndrome and unclas- sified combined immunodeficiency. All these conditions are characterized by functional defects in the humoral and cell mediated immune systems. It remains a matter of debate as to whether granulomatous disease associated with PID represents an immune response to an as yet unidentified pathogen, the occurrence of sarcoidosis in an immune deficient patient, or in the case of CVID a unique disease. CVID is the most common symptomatic PID affecting adults, so this chapter will largely concentrate on granulo- matous disease in CVID.
de Lavallade H, Marin D, Hart M, et al., 2011, Chronic Myeloid Leukemia Patients on Tyrosine Kinase Inhibitor Have Normal T Cell Responses to Vaccination but An Impaired IgM Humoral Response Associate with Loss of Discrete Memory B Cell Subsets, 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: AMER SOC HEMATOLOGY, Pages: 1602-1602, ISSN: 0006-4971
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- Citations: 1
Page EE, Nelson M, Kelleher P, 2011, HIV and hepatitis C coinfection: pathogenesis and microbial translocation, CURRENT OPINION IN HIV AND AIDS, Vol: 6, Pages: 472-477, ISSN: 1746-630X
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- Citations: 44
Clark S, Page E, Ford T, et al., 2011, Reduced T<sub>H</sub>1/T<sub>H</sub>17 CD4 T-cell numbers are associated with impaired purified protein derivative-specific cytokine responses in patients with HIV-1 infection, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 128, Pages: 838-U547, ISSN: 0091-6749
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- Citations: 12
Page EE, Clarke SA, Hart MS, et al., 2011, LIVER FIBROSIS IN HIV/HCV CO-INFECTION: THE ROLE OF TH17 AND TH22 CELLS, 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), Publisher: WILEY-BLACKWELL, Pages: 1323A-1323A, ISSN: 0270-9139
Scourfield A, Waters L, Gazzard B, et al., 2011, Effect of CCR5 inhibitors on immune activation in subjects with suppressed HIV-1 RNA levels, HIV MEDICINE, Vol: 12, Pages: 24-24, ISSN: 1464-2662
Benlahrech A, Gotch F, Kelleher P, et al., 2011, Loss of NK Stimulatory Capacity by Plasmacytoid and Monocyte-Derived DC but Not Myeloid DC in HIV-1 Infected Patients, PLOS ONE, Vol: 6, ISSN: 1932-6203
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- Citations: 16
de Lavallade H, Garland P, Sekine T, et al., 2011, Repeated vaccination is required to optimize seroprotection against H1N1 in the immunocompromised host., Haematologica, Vol: 96, Pages: 307-314
BACKGROUND: In 2009 the declaration by the World Health Organization of a global pandemic of influenza-H1N1 virus led to a vaccination campaign to ensure protection for immunocompromised patients. The goal of this study was to determine the efficacy of the 2009 H1N1 vaccine in patients with hematologic malignancies. DESIGN AND METHODS: We evaluated humoral and cellular immune responses to 2009 H1N1 vaccine in 97 adults with hematologic malignancies and compared these responses with those in 25 adult controls. Patients received two injections of vaccine 21 days apart and the controls received one dose. Antibody titers were measured using a hemagglutination-inhibition assay on days 0, 21 and 49 after injection of the first dose. Cellular immune responses to H1N1 were determined on days 0 and 49. RESULTS: By day 21 post-vaccination, protective antibody titers of 1:32 or more were seen in 100% of controls compared to 39% of patients with B-cell malignancies (P<0.001), 46% of allogeneic stem cell transplant recipients (P<0.001) and 85% of patients with chronic myeloid leukemia (P=0.086). After a second dose, seroprotection rates increased to 68%, (P=0.008), 73%, (P=0.031), and 95% (P=0.5) in patients with B-cell malignancies, after allogeneic stem cell transplantation and with chronic myeloid leukemia, respectively. On the other hand, T-cell responses to H1N1 vaccine were not significantly different between patients and controls. CONCLUSIONS: These data demonstrate the efficacy of H1N1 vaccine in most patients with hematologic malignancies and support the recommendation for the administration of two doses of vaccine in immunocompromised patients. These results may contribute towards the development of evidence-based guidelines for influenza vaccination in such patients in the future.
de Lavallade H, Garland P, Sekine T, et al., 2011, Repeated vaccination is required to optimize seroprotection against H1N1 in the immunocompromised host, HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, Vol: 96, Pages: 307-314, ISSN: 0390-6078
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- Citations: 91
Kaltsidis H, Cheeseman H, Kopycinski J, et al., 2011, Measuring human T cell responses in blood and gut samples using qualified methods suitable for evaluation of HIV vaccine candidates in clinical trials, J Immunol Methods, Vol: 370, Pages: 43-54, ISSN: 1872-7905
Hart M, Page E, Ford T, et al., 2010, Increases in CD21<SUP>low</SUP> B cells are significantly associated with levels of circulating TNF family chemokines BAFF and APRIL in CVID patients, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 96-96, ISSN: 0019-2805
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- Citations: 1
Page EE, Clark S-A, Hart M, et al., 2010, Loss of Th22 cells, rather than a shift from a Th17 to Th1 phenotype, is associated with increased immune activation in HIV-1 infection, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 123-123, ISSN: 0019-2805
Grover V, Singh S, Henderson D, et al., 2010, Use of an inflammatory biomarker panel in the diagnosis of Ventilator-Associated Pneumonia, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 122-122, ISSN: 0019-2805
Cheeseman HM, Kopycinski J, Kaltsidis H, et al., 2010, A qualified approach to measuring T cell responses in parallel blood and gut samples for monitoring HIV vaccine clinical trials, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 101-101, ISSN: 0019-2805
Ford T, Clark SA, Pantelidis P, et al., 2010, IL18R upregulation used in a clinical laboratory approach to identify IFN-γ/IL12 defects in Mendalian Susceptibility to Mycobacterial Disease (MSDM), Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 137-137, ISSN: 0019-2805
de Lavallade H, Garland PL, Sekine T, et al., 2010, 2009 Pandemic Influenza A H1N1 Vaccination In the Patients with Hematologic Malignancies: Requirement for Repeated Dosing to Optimize Seroprotection, 52nd Annual Meeting of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, Pages: 297-298, ISSN: 0006-4971
De Lavallade H, Garland PL, Sekine T, et al., 2010, 2009 Pandemic Influenza A H1N1 Vaccination In the Patients with Hematologic Malignancies Requirement for Repeated Dosing to Optimize Seroprotec, Pages: 297-298, ISSN: 0006-4971
de Lavallade H, Hart M, Gabriel I, et al., 2010, T-cell and B-cell responses after vaccination against influenza virus and pneumococcus in chronic phase CML patients treated with tyrosine kinase inhibitors, 50th Annual Scientific Meeting of the British-Society-for-Haematology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 76-76, ISSN: 0007-1048
Kelleher P, 2010, HIV immunology: what lessons can we learn from recent vaccine trials?, J HIV Ther, Vol: 15, Pages: 2-5, ISSN: 1462-0308
de Lavallade H, Hart M, Gabriel I, et al., 2010, T-cell and B-cell responses after vaccination against influenza virus and pneumococcus in chronic phase CML patients treated with tyrosine kinase inhibitors, 36th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantat/9th Meeting of the EBMT Data-Management-Group/26th Meeting of the EBMT Nurses Group/2nd EBMT Qual Management Meeting, Publisher: NATURE PUBLISHING GROUP, Pages: S243-S243, ISSN: 0268-3369
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