Imperial College London

Dr Peter Kelleher

Faculty of MedicineDepartment of Infectious Disease

Reader in Immunology
 
 
 
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Contact

 

+44 (0)20 3315 8251p.kelleher

 
 
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Location

 

J.2.10Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Schütz:2019:10.1007/s10875-018-0577-9,
author = {Schütz, K and Alecsandru, D and Grimbacher, B and Haddock, J and Bruining, A and Driessen, G and de, Vries E and van, Hagen PM and Hartmann, I and Fraioli, F and Milito, C and Mitrevski, M and Quinti, I and Serra, G and Kelleher, P and Loebinger, M and Litzman, J and Postranecka, V and Thon, V and Babar, J and Condliffe, AM and Exley, A and Kumararatne, D and Screaton, N and Jones, A and Bondioni, MP and Lougaris, V and Plebani, A and Soresina, A and Sirignano, C and Spadaro, G and Galal, N and Gonzalez-Granado, LI and Dettmer, S and Stirling, R and Chapel, H and Lucas, M and Patel, S and Farber, C-M and Meyts, I and Banerjee, AK and Hackett, S and Hurst, JR and Warnatz, K and Gathmann, B and Baumann, U and Chest, CT in Antibody Deficiency Group},
doi = {10.1007/s10875-018-0577-9},
journal = {Journal of Clinical Immunology},
pages = {45--54},
title = {Imaging of bronchial pathology in antibody deficiency: data from the European Chest CT Group},
url = {http://dx.doi.org/10.1007/s10875-018-0577-9},
volume = {39},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. We aimed to establish an international platform for the evaluation of bronchial pathology as assessed by chest CT and to describe the range of bronchial pathologies in patients with antibody deficiency. Ffteen immunodeficiency centres from 9 countries evaluated chest CT scans of patients with ADS using a predefined list of potential findings including an extent score for bronchiectasis. Data of 282 patients with ADS were collected. Patients with common variable immunodeficiency disorders (CVID) comprised the largest subgroup (232 patients, 82.3%). Eighty percent of CVID patients had radiological evidence of bronchial pathology including bronchiectasis in 61%, bronchial wall thickening in 44% and mucus plugging in 29%. Bronchiectasis was detected in 44% of CVID patients aged less than 20 years. Cough was a better predictor for bronchiectasis than spirometry values. Delay of diagnosis as well as duration of disease correlated positively with presence of bronchiectasis. The use of consensus diagnostic criteria and a pre-defined list of bronchial pathologies allows for comparison of chest CT data in multicentre studies. Our data suggest a high prevalence of bronchial pathology in CVID due to late diagnosis or duration of disease.
AU - Schütz,K
AU - Alecsandru,D
AU - Grimbacher,B
AU - Haddock,J
AU - Bruining,A
AU - Driessen,G
AU - de,Vries E
AU - van,Hagen PM
AU - Hartmann,I
AU - Fraioli,F
AU - Milito,C
AU - Mitrevski,M
AU - Quinti,I
AU - Serra,G
AU - Kelleher,P
AU - Loebinger,M
AU - Litzman,J
AU - Postranecka,V
AU - Thon,V
AU - Babar,J
AU - Condliffe,AM
AU - Exley,A
AU - Kumararatne,D
AU - Screaton,N
AU - Jones,A
AU - Bondioni,MP
AU - Lougaris,V
AU - Plebani,A
AU - Soresina,A
AU - Sirignano,C
AU - Spadaro,G
AU - Galal,N
AU - Gonzalez-Granado,LI
AU - Dettmer,S
AU - Stirling,R
AU - Chapel,H
AU - Lucas,M
AU - Patel,S
AU - Farber,C-M
AU - Meyts,I
AU - Banerjee,AK
AU - Hackett,S
AU - Hurst,JR
AU - Warnatz,K
AU - Gathmann,B
AU - Baumann,U
AU - Chest,CT in Antibody Deficiency Group
DO - 10.1007/s10875-018-0577-9
EP - 54
PY - 2019///
SN - 0271-9142
SP - 45
TI - Imaging of bronchial pathology in antibody deficiency: data from the European Chest CT Group
T2 - Journal of Clinical Immunology
UR - http://dx.doi.org/10.1007/s10875-018-0577-9
UR - https://www.ncbi.nlm.nih.gov/pubmed/30547383
UR - http://hdl.handle.net/10044/1/66531
VL - 39
ER -