Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Reader in the Molecular Biology of Muscles



+44 (0)20 7594 1716p.kemp




115Sir Alexander Fleming BuildingSouth Kensington Campus





Paul Kemp is Senior Lecturer at the National Heart and Lung Institute, Imperial College London

Dr Kemp graduated in Biochemistry with Chemistry from Southampton University then studied for his D.Phil in Professor George Radda's group in Oxford University using NMR to investigate the regulation of heart energetics.  After graduating he worked in Professor Jim Metcalfe's group in Cambridge University looking at the mechanisms that control smooth muscle cell proliferation and phenotype.

In 1996 he was awarded a British Heart Foundation Basic Sciences Lectureship staying in the Biochemistry Department in Cambridge and in 2002 was elected a Fellow of Emmanuel College.  Dr Kemp then moved to Imperial to his current position of Senior Lecturer in 2005.

He works on a range of projects related to the control of cell phenotype.  Most of his work is focused on the control of muscle cell phenotype and he has an active collaboration with Professor Mike Polkey at the Royal Brompton Hospital. 

Dr Kemp has supervised a number of research students and was commended in 2010 with the award of a Rector’s Award for Excellence in Research Supervision.

Selected Publications

Journal Articles

Kemp P, Griffiths M, Polkey M, 2019, Muscle wasting in the presence of disease, why is it so variable?, Biological Reviews, Vol:94, ISSN:1464-7931, Pages:1038-105

Garfield B, Crosby A, Shao D, et al., 2019, Growth/differentiation factor 15 causes TGFβ activated kinase 1 dependent muscle atrophy in pulmonary arterial hypertension, Thorax, Vol:74, ISSN:1468-3296, Pages:164-176

Kemp P, Connolly, Paul R, et al., 2017, miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting, Journal of Cachexia, Sarcopenia and Muscle, Vol:9, ISSN:2190-6009, Pages:400-416

Kemp P, paul R, lee J, et al., 2017, miR-422a suppresses SMAD4 protein expression and promotes resistance to muscle loss, Journal of Cachexia Sarcopenia and Muscle, Vol:9, ISSN:2190-5991, Pages:119-128

farre garros, paul R, connolly M, et al., 2017, miR-542 promotes mitochondrial dysfunction and SMAD activity and is raised in ICU Acquired Weakness, American Journal of Respiratory and Critical Care Medicine, Vol:196, ISSN:1073-449X, Pages:1-12

Lewis A, Riddoch-Contreras J, Natanek SA, et al., 2012, Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD, Thorax, Vol:67, ISSN:0040-6376, Pages:26-34

Hyde MJ, Clarke L, Griffin JL, et al., 2011, A single enteral feed prior to the commencement of parenteral nutrition ameliorates the incidence of steatosis in parenterally fed neonatal piglets, Metabolomics, Vol:7, ISSN:1573-3882, Pages:118-125

Man W-C, Natanek SA, Riddoch-Contreras J, et al., 2010, Quadriceps myostatin expression in COPD, European Respiratory Journal, Vol:36, Pages:686-688

Shore A, Karamitri A, Kemp P, et al., 2010, Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue, Diabetologia, Vol:53, ISSN:0012-186X, Pages:1164-1173

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