Publications
139 results found
Lewis A, Sathyapala SA, Riddoch-Contreras J, et al., 2009, REDUCED EXPRESSION AND ACTIVITY OF MYOCARDIN-RELATED TRANSCRIPTION FACTORS CONTRIBUTES TO FIBRE TYPE CHANGES IN THE QUADRICEPS OF PATIENTS WITH COPD, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A134-A134, ISSN: 0040-6376
Man WD, Sathyapala SA, Riddoch-Contreras J, et al., 2009, QUADRICEPS MUSCLE EXPRESSION OF MYOSTATIN IN PATIENTS WITH COPD, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A39-A39, ISSN: 0040-6376
Man WD-C, Kemp P, Moxham J, et al., 2009, Exercise and muscle dysfunction in COPD: implications for pulmonary rehabilitation, CLINICAL SCIENCE, Vol: 117, Pages: 281-291, ISSN: 0143-5221
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- Citations: 31
Man WD, Kemp P, Moxham J, et al., 2009, Exercise and muscle dysfunction in COPD: implications for pulmonary rehabilitation, Clinical Science (Lond), Vol: 117, Pages: 281-291
Skeletal muscle dysfunction in COPD (chronic obstructive pulmonary disease) patients, particularly of the quadriceps, is of clinical interest because it not only influences the symptoms that limit exercise, but may also contribute directly to poor exercise performance and health status, increased healthcare utilization, and mortality. Furthermore, unlike the largely irreversible impairment of the COPD lung, skeletal muscles represent a potential site to improve patients' level of function and quality of life. However, despite expanding knowledge of potential contributing factors and greater understanding of molecular mechanisms of muscle wasting, only one intervention has been shown to be effective in reversing COPD muscle dysfunction, namely exercise training. Pulmonary rehabilitation, an intervention based on individually tailored exercise training, has emerged as arguably the most effective non-pharmacological intervention in improving exercise capacity and health status in COPD patients. The present review describes the effects of chronic exercise training on skeletal muscles and, in particular, focuses on the known effects of pulmonary rehabilitation on the quadriceps muscle in COPD. We also describe the current methods to augment the effects of pulmonary rehabilitation and speculate how greater knowledge of the molecular pathways of skeletal muscle wasting may aid the development of novel pharmaceutical agents
Man WD, Kemp P, Moxham J, et al., 2009, Skeletal muscle dysfunction in COPD: clinical and laboratory observations, Clinical Science (Lond), Vol: 117, Pages: 251-264
COPD (chronic obstructive pulmonary disease), although primarily a disease of the lungs, exhibits secondary systemic manifestations. The skeletal muscles are of particular interest because their function (or dysfunction) not only influences the symptoms that limit exercise, but may contribute directly to poor exercise performance. Furthermore, skeletal muscle weakness is of great clinical importance in COPD as it is recognized to contribute independently to poor health status, increased healthcare utilization and even mortality. The present review describes the current knowledge of the structural and functional abnormalities of skeletal muscles in COPD and the possible aetiological factors. Increasing knowledge of the molecular pathways of muscle wasting will lead to the development of new therapeutic agents and strategies to combat COPD muscle dysfunction.
Hyde MJ, Griffin JL, Herrera E, et al., 2009, Delivery by Caesarean section, rather than vaginal delivery, promotes hepatic steatosis in piglets, Clinical Science (Lond), Vol: EPub CS20090169 [pii]
There has been a marked increase in the number of babies born by elective caesarean section (CS). Following CS, the lack of normal stimuli that occur at birth alters the thermogeneic response but any effects on hepatic metabolism had not been identified. We compared the effect of delivery on hepatic metabolism in piglets, born either by CS or vaginal delivery (VD) and fed by total parenteral nutrition, by measuring lipid metabolism and enzyme activity coupled with metabolomic and genomic approaches. Hepatic lipid in the CS piglets 7 days post-partum was in excess of 5mg/g of liver consistent with hepatic steatosis whereas in the VD piglets the amount of lipid was markedly lower (3mg/g) and below the threshold for a diagnosis of steatosis. Metabolomic analysis indicated that CS resulted in higher hepatic glycerol and lower glycerol phosphate-dehydrogenase activity suggesting that CS causes an decrease in hepatic gluconeogenesis from glycerol. CS also resulted in altered cholesterol handling and gene expression despite the same dietary intake 7 days post-partum. Furthermore the CS piglets had lower expression of interferon responsive genes, but higher expression of markers of immature hepatocytes. The data suggest that VD promotes normal liver maturation and hepatic metabolism, thereby reducing the accumulation of hepatic lipid.
Contreras JR, Sathyapala SA, Marsh GS, et al., 2008, FOUR AND A HALF LIM PROTEIN 1 EXPRESSION AND AKT PHOSPHORYLATION IN QUADRICEPS MUSCLE IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS AND ITS RELATION TO MUSCLE STRENGTH AND PHYSICAL ACTIVITY, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A24-A24, ISSN: 0040-6376
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- Citations: 1
Outram SV, Gordon AR, Hager-Theodorides AL, et al., 2008, KLF13 influences multiple stages of both B and T cell development, CELL CYCLE, Vol: 7, Pages: 2047-2055, ISSN: 1538-4101
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- Citations: 22
Gordon AR, Outram SV, Keramatipour M, et al., 2008, Splenomegaly and modified erythropoiesis in KLF13<SUP>-/-</SUP> mice, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 283, Pages: 11897-11904
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- Citations: 28
Sathyapala SA, Marsh GS, Hopkinson NS, et al., 2007, Muscle ring finger protein 1 (MuRF-1), atrogin-1 and muscle wasting in COPD, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A137-A138, ISSN: 0040-6376
Sathyapala SA, Kemp P, Polkey MI, 2007, Decreased muscle PPAR concentrations: a mechanism underlying skeletal muscle abnormalities in COPD?, Europeran Respir Journal, Vol: 30, Pages: 191-193
Kemp PR, Ellis PD, Smith CWJ, 2005, Visualization of alternative splicing in vivo, METHODS, Vol: 37, Pages: 360-367, ISSN: 1046-2023
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- Citations: 4
Favot L, Hall SM, Haworth SG, et al., 2005, Cytoplasmic YY1 is associated with increased smooth muscle-specific gene expression - Implications for neonatal pulmonary hypertension, AMERICAN JOURNAL OF PATHOLOGY, Vol: 167, Pages: 1497-1509, ISSN: 0002-9440
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- Citations: 35
Favot L, Gillingwater M, Scott C, et al., 2005, Overexpression of a family of RPEL proteins modifies cell shape, FEBS LETTERS, Vol: 579, Pages: 100-104, ISSN: 1873-3468
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- Citations: 16
Keramatipour M, Goddard CA, Colledge WH, et al., 2004, Hypertension and cardiac hypertrophy in BTEB3 null mice, HEART, Vol: 90, ISSN: 1355-6037
Gordon AR, Metcalfe J, Kemp PR, 2004, Alternative splicing of serum response factor, HEART, Vol: 90, ISSN: 1355-6037
Ellis PD, Smith CWJ, Kemp P, 2004, Regulated tissue-specific alternative splicing of enhanced green fluorescent protein transgenes conferred by α-tropomyosin regulatory elements in transgenic mice, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 279, Pages: 36660-36669, ISSN: 0021-9258
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- Citations: 39
Keramatipour M, Ellis PD, Grace AA, et al., 2003, The role of transcription factor BTEB3 in the regulation of smooth muscle-specific gene expression in vivo., Annual Meeting of the American-Society-of-Human-Genetics, Publisher: UNIV CHICAGO PRESS, Pages: 343-343, ISSN: 0002-9297
Martin KM, Ellis PD, Metcalfe JC, et al., 2003, Selective modulation of the SM22α promoter by the binding of BTEB3 (basal transcription element-binding protein 3) to TGGG repeats, BIOCHEMICAL JOURNAL, Vol: 375, Pages: 457-463, ISSN: 0264-6021
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- Citations: 8
Ellis PD, Metcalfe JC, Hyvonen M, et al., 2003, Adhesion of endothelial cells to NOV is mediated by the integrins αvβ3 and α5β1, JOURNAL OF VASCULAR RESEARCH, Vol: 40, Pages: 234-243, ISSN: 1018-1172
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- Citations: 28
Dunning AM, Ellis PD, McBride S, et al., 2003, A transforming growth factorβ1 signal peptide variant increases secretion <i>in vitro</i> and is associated with increased incidence of invasive breast cancer, CANCER RESEARCH, Vol: 63, Pages: 2610-2615, ISSN: 0008-5472
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- Citations: 286
Gooding C, Kemp P, Smith CWJ, 2003, A novel polypyrimidine tract-binding protein paralog expressed in smooth muscle cells, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 278, Pages: 15201-15207, ISSN: 0021-9258
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- Citations: 40
Ellis PD, Martin KM, Rickman C, et al., 2002, Increased actin polymerization reduces the inhibition of serum response factor activity by Yin Yang 1, BIOCHEMICAL JOURNAL, Vol: 364, Pages: 547-554, ISSN: 0264-6021
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- Citations: 30
Lu Y, Mahaut-Smith MP, Varghese A, et al., 2001, Effects of premature stimulation on HERG K<SUP>+</SUP> channels, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 537, Pages: 843-851, ISSN: 0022-3751
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- Citations: 97
Lu Y, Mahaut-Smith MP, Varghese A, et al., 2001, Effects of premature stimulation on HERG K+ channels, The Journal of Physiology, Vol: 537, Pages: 843-851, ISSN: 0022-3751
Martin KM, Metcalfe JC, Kemp PR, 2001, Expression of Klf9 and Klf13 in mouse development, MECHANISMS OF DEVELOPMENT, Vol: 103, Pages: 149-151, ISSN: 0925-4773
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- Citations: 29
Lücke CD, Philpott A, Metcalfe JC, et al., 2001, Inhibiting mutations in the transforming growth factor β type 2 receptor in recurrent human breast cancer, CANCER RESEARCH, Vol: 61, Pages: 482-485, ISSN: 0008-5472
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- Citations: 59
Yang Y, Beqaj S, Kemp P, et al., 2000, Stretch-induced alternative splicing of serum response factor promotes bronchial myogenesis and is defective in lung hypoplasia, JOURNAL OF CLINICAL INVESTIGATION, Vol: 106, Pages: 1321-1330, ISSN: 0021-9738
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- Citations: 95
Ellis PD, Chen Q, Barker PJ, et al., 2000, <i>Nov</i> gene encodes adhesion factor for vascular smooth muscle cells and is dynamically regulated in response to vascular injury, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 20, Pages: 1912-1919, ISSN: 1079-5642
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- Citations: 58
Kemp PR, Metcalfe JC, 2000, Four isoforms of serum response factor that increase or inhibit smooth-muscle-specific promoter activity, BIOCHEMICAL JOURNAL, Vol: 345, Pages: 445-451, ISSN: 0264-6021
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- Citations: 52
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