Imperial College London
Alternate

DrPaulKemp

Faculty of Medicine, National Heart & Lung Institute

Reader in the Molecular Biology of Muscles
 
 
 
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Contact

 

+44 (0)20 7594 1716p.kemp

 
 
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Location

 

115Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Shrestha:2022:10.14336/AD.2022.0404,
author = {Shrestha, A and Dani, M and Kemp, P and Fertleman, M},
doi = {10.14336/AD.2022.0404},
journal = {Aging and Disease},
pages = {1759--1769},
title = {Acute sarcopenia after elective and emergency surgery},
url = {http://dx.doi.org/10.14336/AD.2022.0404},
volume = {13},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AbstractSarcopenia is an increasingly recognised condition of loss of muscle mass and function. The European Working Group on Sarcopenia in Older People 2 (EWSOP2) updated their definition in 2018, emphasising the importance of low muscle strength in diagnosis. Acute sarcopenia has been arbitrarily defined as sarcopenia lasting less than 6 months. This review highlights the pathophysiology involved in muscle wasting following surgery, focussing on hormonal factors, inflammation, microRNAs, and oxidative stress. Biomarkers such as GDF-15, IGF-1 and various microRNAs may predict post-surgical muscle loss. The impact of existing sarcopenia on various types of surgery and incident muscle wasting following surgery is also described. The gaps in research found include the need for longitudinal studies looking in changes in muscle strength and quantity following surgery. Further work is needed to examine if biomarkers are replicated in other surgery to consolidate existing theories on the pathophysiology of muscle wasting
AU  - Shrestha,A
AU  - Dani,M
AU  - Kemp,P
AU  - Fertleman,M
DO  - 10.14336/AD.2022.0404
EP  - 1769
PY  - 2022///
SN  - 2152-5250
SP  - 1759
TI  - Acute sarcopenia after elective and emergency surgery
T2  - Aging and Disease
UR  - http://dx.doi.org/10.14336/AD.2022.0404
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000789643500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://www.aginganddisease.org/EN/10.14336/AD.2022.0404
UR  - http://hdl.handle.net/10044/1/97494
VL  - 13
ER  -
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