Imperial College London
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ProfessorPeterKohl

Faculty of Medicine, National Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

p.kohl Website

 
 
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Location

 

Heart Science CentreHarefield Hospital

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Summary

 

Publications

Citation

BibTex format

@article{Rog-Zielinska:2019:10.1002/ar.23917,
author = {Rog-Zielinska, EA and O'Toole, ET and Hoenger, A and Kohl, P},
doi = {10.1002/ar.23917},
journal = {Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology},
pages = {146--152},
title = {Mitochondrial deformation during the cardiac mechanical cycle},
url = {http://dx.doi.org/10.1002/ar.23917},
volume = {302},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cardiomyocytes both cause and experience continual cyclic deformation. The exact effects of this deformation on the properties of intracellular organelles are not well characterized, although they are likely to be relevant for cardiomyocyte responses to active and passive changes in their mechanical environment. In the present study we provide threedimensional ultrastructural evidence for mechanically induced mitochondrial deformation in rabbit ventricular cardiomyocytes over a range of sarcomere lengths representing myocardial tissue stretch, an unloaded “slack” state, and contracture. We also show structural indications for interaction of mitochondria with one another, as well as with other intracellular elements such as microtubules, sarcoplasmic reticulum and Ttubules. The data presented here help to contextualize recent reports on the mechanosensitivity and cellwide connectivity of the mitochondrial network and provide a structural framework that may aide interpretation of mechanicallyregulated molecular signaling in cardiac cells. Anat Rec, 302:146–152, 2019. © 2018 The Authors. The Anatomical Record published by Wiley Periodicals, Inc. on behalf of American Association of Anatomists.
AU  - Rog-Zielinska,EA
AU  - O'Toole,ET
AU  - Hoenger,A
AU  - Kohl,P
DO  - 10.1002/ar.23917
EP  - 152
PY  - 2019///
SN  - 0749-3002
SP  - 146
TI  - Mitochondrial deformation during the cardiac mechanical cycle
T2  - Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
UR  - http://dx.doi.org/10.1002/ar.23917
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000459881400016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://anatomypubs.onlinelibrary.wiley.com/doi/full/10.1002/ar.23917
UR  - http://hdl.handle.net/10044/1/84725
VL  - 302
ER  -
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