Imperial College London
Portrait Picture

ProfessorPeterKohl

Faculty of Medicine, National Heart & Lung Institute

Visiting Professor
 
 
 
//

Contact

 

p.kohl Website

 
 
//

Location

 

Heart Science CentreHarefield Hospital

//

Summary

 

Publications

Citation

BibTex format

@article{Hulsmans:2017:10.1016/j.cell.2017.03.050,
author = {Hulsmans, M and Clauss, S and Xiao, L and Aguirre, AD and King, KR and Hanley, A and Hucker, WJ and Wuelfers, EM and Seemann, G and Courties, G and Iwamoto, Y and Sun, Y and Savol, AJ and Sager, HB and Lavine, KJ and Fishbein, GA and Capen, DE and Da, Silva N and Miquerol, L and Wakimoto, H and Seidman, CE and Seidman, JG and Sadreyev, RI and Naxerova, K and Mitchell, RN and Brown, D and Libby, P and Weissleder, R and Swirski, FK and Kohl, P and Vinegoni, C and Milan, DJ and Ellinor, PT and Nahrendorf, M},
doi = {10.1016/j.cell.2017.03.050},
journal = {Cell},
pages = {510--522},
title = {Macrophages facilitate electrical conduction in the heart},
url = {http://dx.doi.org/10.1016/j.cell.2017.03.050},
volume = {169},
year = {2017}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Organ-specific functions of tissue-resident macrophages in the steady-state heart are unknown. Here, we show that cardiac macrophages facilitate electrical conduction through the distal atrioventricular node, where conducting cells densely intersperse with elongated macrophages expressing connexin 43. When coupled to spontaneously beating cardiomyocytes via connexin-43-containing gap junctions, cardiac macrophages have a negative resting membrane potential and depolarize in synchrony with cardiomyocytes. Conversely, macrophages render the resting membrane potential of cardiomyocytes more positive and, according to computational modeling, accelerate their repolarization. Photostimulation of channelrhodopsin-2-expressing macrophages improves atrioventricular conduction, whereas conditional deletion of connexin 43 in macrophages and congenital lack of macrophages delay atrioventricular conduction. In the Cd11bDTR mouse, macrophage ablation induces progressive atrioventricular block. These observations implicate macrophages in normal and aberrant cardiac conduction.
AU  - Hulsmans,M
AU  - Clauss,S
AU  - Xiao,L
AU  - Aguirre,AD
AU  - King,KR
AU  - Hanley,A
AU  - Hucker,WJ
AU  - Wuelfers,EM
AU  - Seemann,G
AU  - Courties,G
AU  - Iwamoto,Y
AU  - Sun,Y
AU  - Savol,AJ
AU  - Sager,HB
AU  - Lavine,KJ
AU  - Fishbein,GA
AU  - Capen,DE
AU  - Da,Silva N
AU  - Miquerol,L
AU  - Wakimoto,H
AU  - Seidman,CE
AU  - Seidman,JG
AU  - Sadreyev,RI
AU  - Naxerova,K
AU  - Mitchell,RN
AU  - Brown,D
AU  - Libby,P
AU  - Weissleder,R
AU  - Swirski,FK
AU  - Kohl,P
AU  - Vinegoni,C
AU  - Milan,DJ
AU  - Ellinor,PT
AU  - Nahrendorf,M
DO  - 10.1016/j.cell.2017.03.050
EP  - 522
PY  - 2017///
SN  - 0092-8674
SP  - 510
TI  - Macrophages facilitate electrical conduction in the heart
T2  - Cell
UR  - http://dx.doi.org/10.1016/j.cell.2017.03.050
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000399560600014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/48423
VL  - 169
ER  -
Download