Imperial College London
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DrPascaleKropf

Faculty of Medicine, Department of Infectious Disease

Reader in Immunology
 
 
 
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Contact

 

+44 (0)20 7594 1755p.kropf

 
 
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Location

 

120Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Takele:2022:10.1016/j.xcrm.2021.100487,
author = {Takele, Y and Mulaw and Adem and Shaw, E and Franssen and Womersley, R and Kaforou, M and Taylor, G and Levin, M and Muller, I and Cotton and Kropf, P},
doi = {10.1016/j.xcrm.2021.100487},
journal = {Cell Reports Medicine},
title = {Immunological factors, but not clinical features, predict visceral leishmaniasis relapse in patients co-infected with HIV},
url = {http://dx.doi.org/10.1016/j.xcrm.2021.100487},
volume = {3},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Visceral leishmaniasis (VL) has emerged as a clinically important opportunistic infection in HIV patients, as VL/HIV co-infected patients suffer from frequent VL relapse. Here, we follow cohorts of VL patients with or without HIV in Ethiopia. By the end of the study 78.1% of VL/HIV, but none of the VL patients, experience VL relapse. Despite clinically defined cure, VL/HIV patients maintain higher parasite loads, lower BMI, hepatosplenomegaly and pancytopenia. We identify three immunological markers associated with VL relapse in VL/HIV patients: i) failure to restore antigen-specific production of IFNg, ii) persistently lower CD4+ T cell counts, and iii) higher expression of PD1 on CD4+ and CD8+ T cells. We show that these three markers, that can be measured in primary hospital settings in Ethiopia, combine well in predicting VL relapse. The use of our prediction model has the potential to improve disease management and patient care.
AU  - Takele,Y
AU  - Mulaw
AU  - Adem
AU  - Shaw,E
AU  - Franssen
AU  - Womersley,R
AU  - Kaforou,M
AU  - Taylor,G
AU  - Levin,M
AU  - Muller,I
AU  - Cotton
AU  - Kropf,P
DO  - 10.1016/j.xcrm.2021.100487
PY  - 2022///
SN  - 2666-3791
TI  - Immunological factors, but not clinical features, predict visceral leishmaniasis relapse in patients co-infected with HIV
T2  - Cell Reports Medicine
UR  - http://dx.doi.org/10.1016/j.xcrm.2021.100487
UR  - https://www.sciencedirect.com/science/article/pii/S2666379121003591?via%3Dihub
UR  - http://hdl.handle.net/10044/1/93210
VL  - 3
ER  -
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