Imperial College London
Portrait Picture

DrPascaleKropf

Faculty of Medicine, Department of Infectious Disease

Reader in Immunology
 
 
 
//

Contact

 

+44 (0)20 7594 1755p.kropf

 
 
//

Location

 

120Praed StreetSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Chan:2022:10.1038/s41467-022-28620-1,
author = {Chan, D and Bennett, P and Lee, YS and Kundu, S and Teoh, TG and Adan, M and Ahmed, S and Brown, RG and David, A and Lewis, H and Gimeno-, Molina B and Norman, J and Stock, S and Terzidou, V and Kropf, P and Botto, M and MacIntyre, D and Sykes, L},
doi = {10.1038/s41467-022-28620-1},
journal = {Nature Communications},
title = {Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response},
url = {http://dx.doi.org/10.1038/s41467-022-28620-1},
volume = {13},
year = {2022}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There has been a surge in studies implicating a role of vaginal microbiota in spontaneous preterm birth (sPTB), but most are associative without mechanistic insight. Here we show a comprehensive approach to understand the causative factors of preterm birth, based on the integration of longitudinal vaginal microbiota and cervicovaginal fluid (CVF) immunophenotype data collected from 133 women at high-risk of sPTB. We show that vaginal depletion of Lactobacillus species and high bacterial diversity leads to increased mannose binding lectin (MBL), IgM, IgG, C3b, C5, IL-8, IL-6 and IL-1β and to increased risk of sPTB. Cervical shortening, which often precedes preterm birth, is associated with Lactobacillus iners and elevated levels of IgM, C3b, C5, C5a and IL-6. These data demonstrate a role for the complement system in microbial-driven sPTB and provide a scientific rationale for the development of live biotherapeutics and complement therapeutics to prevent sPTB.
AU  - Chan,D
AU  - Bennett,P
AU  - Lee,YS
AU  - Kundu,S
AU  - Teoh,TG
AU  - Adan,M
AU  - Ahmed,S
AU  - Brown,RG
AU  - David,A
AU  - Lewis,H
AU  - Gimeno-,Molina B
AU  - Norman,J
AU  - Stock,S
AU  - Terzidou,V
AU  - Kropf,P
AU  - Botto,M
AU  - MacIntyre,D
AU  - Sykes,L
DO  - 10.1038/s41467-022-28620-1
PY  - 2022///
SN  - 2041-1723
TI  - Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-022-28620-1
UR  - http://hdl.handle.net/10044/1/94959
VL  - 13
ER  -
Download