Imperial College London
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DrPascaleKropf

Faculty of Medicine, Department of Infectious Disease

Reader in Immunology
 
 
 
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Contact

 

+44 (0)20 7594 1755p.kropf

 
 
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Location

 

120Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Takele:2022:10.1371/journal.pntd.0010681,
author = {Takele, Y and Adem, E and Mulaw, T and Müller, I and Cotton, JA and Kropf, P},
doi = {10.1371/journal.pntd.0010681},
journal = {PLoS Neglected Tropical Diseases},
title = {Following successful anti-leishmanial treatment, neutrophil counts, CD10 expression and phagocytic capacity remain reduced in visceral leishmaniasis patients co-infected with HIV},
url = {http://dx.doi.org/10.1371/journal.pntd.0010681},
volume = {16},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Visceral leishmaniasis (VL) patients co-infected with HIV (VL/HIV patients) experience frequent treatment failures, VL relapses, opportunistic infections, and higher mortality. Their immune system remains profoundly suppressed after clinical cure and they maintain higher parasite load. This is in contrast with patients with VL alone (VL patients). Since neutrophils play a critical role in the control of Leishmania replication and the regulation of immune responses, we tested the hypothesis that neutrophil activation status and effector functions are fully restored in VL, but not in VL/HIV patients. Our results show the neutrophil counts and all activation markers and effector functions tested in our study were reduced at the time of diagnosis in VL and VL/HIV patients as compared to controls. CD62L, CD63, arginase 1 expression levels and reactive oxygen species production were restored at the end of treatment in both groups. However, neutrophil counts, CD10 expression and phagocytosis remained significantly lower throughout follow-up in VL/HIV patients; suggesting that dysregulated neutrophils contribute to the impaired host defence against pathogens in VL/HIV patients.
AU  - Takele,Y
AU  - Adem,E
AU  - Mulaw,T
AU  - Müller,I
AU  - Cotton,JA
AU  - Kropf,P
DO  - 10.1371/journal.pntd.0010681
PY  - 2022///
SN  - 1935-2727
TI  - Following successful anti-leishmanial treatment, neutrophil counts, CD10 expression and phagocytic capacity remain reduced in visceral leishmaniasis patients co-infected with HIV
T2  - PLoS Neglected Tropical Diseases
UR  - http://dx.doi.org/10.1371/journal.pntd.0010681
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35969625
UR  - http://hdl.handle.net/10044/1/101283
VL  - 16
ER  -
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