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@article{Gimeno-Molina:2022:10.3390/life12101512,
author = {Gimeno-Molina, B and Muller, I and Kropf, P and Sykes, L},
doi = {10.3390/life12101512},
journal = {Life},
title = {The role of neutrophils in pregnancy, term and preterm labour},
url = {http://dx.doi.org/10.3390/life12101512},
volume = {12},
year = {2022}
}

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TY  - JOUR
AB  - Neutrophils are surveillance cells, and the first to react and migrate to sites of inflammation and infection following a chemotactic gradient. Neutrophils play a key role in both sterile inflammation and infection, performing a wide variety of effector functions such as degranulation, phagocytosis, ROS production and release of neutrophil extracellular traps (NETs). Healthy term labour requires a sterile pro-inflammatory process, whereas one of the most common causes of spontaneous preterm birth is microbial driven. Peripheral neutrophilia has long been described during pregnancy, and evidence exists demonstrating neutrophils infiltrating the cervix, uterus and foetal membranes during both term and preterm deliveries. Their presence supports a role in tissue remodelling via their effector functions. In this review, we describe the effector functions of neutrophils. We summarise the evidence to support their role in healthy pregnancy and labour and describe their potential contribution to microbial driven preterm birth.
AU  - Gimeno-Molina,B
AU  - Muller,I
AU  - Kropf,P
AU  - Sykes,L
DO  - 10.3390/life12101512
PY  - 2022///
SN  - 2075-1729
TI  - The role of neutrophils in pregnancy, term and preterm labour
T2  - Life
UR  - http://dx.doi.org/10.3390/life12101512
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36294949
UR  - http://hdl.handle.net/10044/1/100287
VL  - 12
ER  -

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